ACBP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACBP2_ARATH
• UniProt AC: Q9STP8
• Protein Name: Acyl-CoA-binding domain-containing protein 2
• Gene Name: ACBP2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 354
• Subcellular Localization: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
• Protein Description: Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with palmitoyl-CoA, but not with oleoyl-CoA. Binds to lead ions (Pb). May function as an intracellular carrier of acyl-CoA esters. Required for proper phospholipid and, to a lower extent, galactolipid composition..
• Protein Sequence: MGDWAQLAQSVILGLIFSYLLAKLISIVVTFKEDNLSLTRHPEESQLEIKPEGVDSRRLDSSCGGFGGEADSLVAEQGSSRSDSVAGDDSEEDDDWEGVESTELDEAFSAATLFVTTAAADRLSQKVPSDVQQQLYGLYKIATEGPCTAPQPSALKMTARAKWQAWQKLGAMPPEEAMEKYIEIVTQLYPTWLDGGVKAGSRGGDDAASNSRGTMGPVFSSLVYDEESENELKIDAIHGFAREGEVENLLKSIESGIPVNARDSEGRTPLHWAIDRGHLNIAKVLVDKNADVNAKDNEGQTPLHYAVVCDREAIAEFLVKQNANTAAKDEDGNSPLDLCESDWPWIRDSAKQAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	SLVAEQGSSRSDSVA HHHHCCCCCCCCCCC	23.44	19880383
153	Phosphorylation	PCTAPQPSALKMTAR CCCCCCCCHHHHHHH	40.77	24894044
158	Phosphorylation	QPSALKMTARAKWQA CCCHHHHHHHHHHHH	16.05	24894044
209	Phosphorylation	RGGDDAASNSRGTMG CCCCCCHHCCCCCCC	36.74	23776212
211	Phosphorylation	GDDAASNSRGTMGPV CCCCHHCCCCCCCCH	29.59	23776212
214	Phosphorylation	AASNSRGTMGPVFSS CHHCCCCCCCCHHHH	20.18	23776212
220	Phosphorylation	GTMGPVFSSLVYDEE CCCCCHHHHHCCCCC	24.01	23776212
221	Phosphorylation	TMGPVFSSLVYDEES CCCCHHHHHCCCCCC	15.47	23776212
224	Phosphorylation	PVFSSLVYDEESENE CHHHHHCCCCCCCCC	23.95	23776212
228	Phosphorylation	SLVYDEESENELKID HHCCCCCCCCCEEEE	43.61	23776212
264	Phosphorylation	IPVNARDSEGRTPLH CCCCCCCCCCCCCCE	36.08	25561503
268	Phosphorylation	ARDSEGRTPLHWAID CCCCCCCCCCEEEEE	40.85	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACBP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACBP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACBP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAP23_ARATH	EBP	physical	15159625
HIP26_ARATH	FP6	physical	18823312

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.