AATF_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AATF_RAT
• UniProt AC: Q9QYW0
• Protein Name: Protein AATF
• Gene Name: Aatf
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 523
• Subcellular Localization: Nucleus .
• Protein Description: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation..
• Protein Sequence: MAELQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEEDDLPVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWDQTLPSSSDNEIPDEGGSEAGDSEGLEELSEDVEEDLEDNEIPDEGGSEDGDSEGLEEEISEDVEEDLEGEDEEDREEDRNSEDDGVVMAFSGVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRYLVKGTKPNAESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRSADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPESLPQVPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMNDEARTELYRSLFGQLNRLDADHGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELQPLAL ------CCCHHHHHH	26.63	-
62	Phosphorylation	IRKLAPVSLLDTDKR HHHHCCEEHHCCCCC	23.35	-
167	Phosphorylation	DREEDRNSEDDGVVM HHHHHHCCCCCCEEE	43.21	30181290
237	Phosphorylation	KGGPEFASALKNSHK CCCHHHHHHHHHHHH	39.18	-
274	Phosphorylation	TRYLVKGTKPNAESE CCEEECCCCCCCCCC	37.30	26437020
280	Phosphorylation	GTKPNAESEEISSED CCCCCCCCCCCCCCC	37.81	29779826
284	Phosphorylation	NAESEEISSEDDELV CCCCCCCCCCCCHHH	30.84	29779826
285	Phosphorylation	AESEEISSEDDELVG CCCCCCCCCCCHHHH	51.19	29779826
319	Phosphorylation	PSFMAKRSADFTVYR HHHHHHHCCCEEEEE	31.33	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AATF_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AATF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AATF_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MNS1_RAT	Mns1	physical	17552904
TS101_RAT	Tsg101	physical	17552904
BL1S2_RAT	Bloc1s2	physical	17552904

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.