AATF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AATF_DROME
• UniProt AC: Q9VM95
• Protein Name: Protein Aatf
• Gene Name: Aatf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 488
• Subcellular Localization: Nucleus.
• Protein Description: May function as a general inhibitor of the histone deacetylase HDAC1..
• Protein Sequence: MLRKSKKQPQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEEDHSQESEGDDDDSEDDEAEDDAIKPSDVMSKTNHQAEIQKGLAVQNQLRIWERLLELRINTQKFTSKANQLPAPETLTKLASESDELQSVLNEAQERSSKLLQQLLSLQSALHQQYSEMKKSVKRKQPTEDSGPAVKKFGSVLQSNFQQMIGYRNEVLLKWDDRTKLLTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQTPKNSQAEQQENTPVQRLKHIYDDSDFYHQQLRELIEYKASTSSNMSEITKQFVELQKLRQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	QPQTVAEKVSKLLAH CCHHHHHHHHHHHHC	41.91	21791702
26	Phosphorylation	LLAHPNESDSAEDSD HHHCCCCCCCCCCCC	43.43	19429919
28	Phosphorylation	AHPNESDSAEDSDFD HCCCCCCCCCCCCCC	42.72	19429919
32	Phosphorylation	ESDSAEDSDFDVATG CCCCCCCCCCCCCCC	31.51	19429919
38	Phosphorylation	DSDFDVATGPRLVDF CCCCCCCCCCEEECC	47.79	19429919
98	Phosphorylation	KDDEQEVSYEESDED CCCCHHHCHHCCCCC	26.52	20450229
102	Phosphorylation	QEVSYEESDEDDENL HHHCHHCCCCCCCCC	34.07	20450229
351	Phosphorylation	GAGVKRKSLQEDYDI CCCCCHHHHHHHHHH	39.04	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AATF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AATF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AATF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEK_DROME	wek	physical	14605208
RL13_DROME	RpL13	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-28 AND SER-32,AND MASS SPECTROMETRY.
PubMed: 18327897