dbPTM

AAR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AAR2_SCHPO
UniProt AC	Q6LA53
Protein Name	A1 cistron-splicing factor aar2
Gene Name	aar2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	346
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity)..
Protein Sequence	MSIEFVGWLNTYYVGIDQSSYEASKLPGIRNVKGGIHLFTWSPTYPAGLISGVFAMVHEDMKYSIDFDSKSETASLQKLDVLYDENFYPFESTKDWDLLTKFITVQDLQRIFATEGEFFYLDTSTYVNADLVSQDPEFSKPSRDDKLLNFAEFNLRRSWSPSATGPERSKQAIDKSFLFQRLVQSVWNDNPISALAELSISFLSYSILSHYGALEHWKNMLSLLLQSYELAETEPEFYASFLELFKLQLSSLSESDLETSAIFEKGVLLSCLDSLSERKVDGSFGSLVNEAIENLLKTISELLNSHEEQAGLMQKGDLYSAADYEAEVHETGDYVIDVSTEEDPIH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
158	Phosphorylation	AEFNLRRSWSPSATG HHHHCCCCCCCCCCC	26.02	29996109
160	Phosphorylation	FNLRRSWSPSATGPE HHCCCCCCCCCCCCH	15.38	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AAR2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AAR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AAR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RL30A_SCHPO	rpl3001	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AAR2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY.	18257517 [Abstract]