5HT2B_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT2B_DROME
• UniProt AC: P28286
• Protein Name: 5-hydroxytryptamine receptor 2B
• Gene Name: 5-HT1B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 617
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase..
• Protein Sequence: MLKTVTTAMAAGDDDVPASILEIELPAILLNESLFIELNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARARSAKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	N-linked_Glycosylation	ELPAILLNESLFIEL ECCCHHHCCCEEEEE	33.11	-
41	N-linked_Glycosylation	LFIELNGNLTQLVDT EEEEECCCEEHHEEC	38.55	-
51	N-linked_Glycosylation	QLVDTTSNLSQIVWN HHEECCCCHHHHHCC	41.44	-
58	N-linked_Glycosylation	NLSQIVWNRSINGNG CHHHHHCCCCCCCCC	19.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT2B_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT2B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT2B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRY1_DROME	cry	genetic	15996552

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.