1433F_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433F_RAT
• UniProt AC: P68511
• Protein Name: 14-3-3 protein eta
• Gene Name: Ywhah
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 246
• Subcellular Localization: Cytoplasm.
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)..
• Protein Sequence: MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLALLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDREQLLQ ------CCHHHHHHH	42.56	-
25	Phosphorylation	ERYDDMASAMKAVTE HHHHHHHHHHHHHHH	23.43	-
46	Phosphorylation	NEDRNLLSVAYKNVV HHHCCHHHHHHHHHH	14.10	27097102
49	Phosphorylation	RNLLSVAYKNVVGAR CCHHHHHHHHHHCCC	10.84	23984901
50	Acetylation	NLLSVAYKNVVGARR CHHHHHHHHHHCCCC	33.26	13577405
50	Ubiquitination	NLLSVAYKNVVGARR CHHHHHHHHHHCCCC	33.26	-
59	Phosphorylation	VVGARRSSWRVISSI HHCCCCCCCHHHHHH	19.65	13577399
64	Phosphorylation	RSSWRVISSIEQKTM CCCCHHHHHHHHHHC	23.54	25403869
65	Phosphorylation	SSWRVISSIEQKTMA CCCHHHHHHHHHHCC	21.01	22673903
69	Ubiquitination	VISSIEQKTMADGNE HHHHHHHHHCCCCCH	27.72	-
69	Acetylation	VISSIEQKTMADGNE HHHHHHHHHCCCCCH	27.72	22902405
77	Acetylation	TMADGNEKKLEKVKA HCCCCCHHHHHHHHH	67.66	22902405
77	Ubiquitination	TMADGNEKKLEKVKA HCCCCCHHHHHHHHH	67.66	-
117	Phosphorylation	KNCNDFQYESKVFYL HCCCCCCEEECEEEE	23.36	13577425
125	Acetylation	ESKVFYLKMKGDYYR EECEEEEEECCHHHH	27.47	13577415
125	Ubiquitination	ESKVFYLKMKGDYYR EECEEEEEECCHHHH	27.47	-
127	Acetylation	KVFYLKMKGDYYRYL CEEEEEECCHHHHHH	47.22	14505115
127	Ubiquitination	KVFYLKMKGDYYRYL CEEEEEECCHHHHHH	47.22	-
142	Acetylation	AEVASGEKKNSVVEA HHHHCCCCCCCHHHH	61.86	22902405
142	Ubiquitination	AEVASGEKKNSVVEA HHHHCCCCCCCHHHH	61.86	-
143	Ubiquitination	EVASGEKKNSVVEAS HHHCCCCCCCHHHHH	50.59	-
215	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	22673903
219	Phosphorylation	NEDSYKDSTLIMQLL CCCCCCCHHHHHHHH	22.44	22673903
220	Phosphorylation	EDSYKDSTLIMQLLR CCCCCCHHHHHHHHH	30.36	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433F_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
59	S	Phosphorylation	Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433F_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NF1_RAT	Nf1	physical	14741381

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.