ZXDB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZXDB_HUMAN
• UniProt AC: P98169
• Protein Name: Zinc finger X-linked protein ZXDB
• Gene Name: ZXDB
• Organism: Homo sapiens (Human).
• Sequence Length: 803
• Subcellular Localization: Nucleus .
• Protein Description: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes..
• Protein Sequence: MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLLRGPQDGGPGRRREEASTASRGPGPSLLAPRTDQPSGGGGGGGDDFFLVLLDPVGGDVETAGSGQAAGPVLREEAEEGPGLQGGESGANPAGPTALGPRCLSAVPTPAPISAPGPAAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQAGFPHAAHPGDCPELPPDLLLAEPAEPAPAPAPEEEAEGPAAALGPRGPLGSGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSAHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDALTPSSTLCENSVSELLTPTKAEWNVHPDSDFFGQEGETQFGFPNAAGNHGSQKETDLITVTGSSFLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	RVHRGPDSPAGQVPT CCCCCCCCCCCCCCC	21.56	16964243
41	Phosphorylation	SPAGQVPTRRLLLLR CCCCCCCCCEEEEEC	29.57	28985074
66	Phosphorylation	REEASTASRGPGPSL HHHHCCCCCCCCCCC	37.55	22210691
72	Phosphorylation	ASRGPGPSLLAPRTD CCCCCCCCCCCCCCC	41.76	22210691
294	Phosphorylation	QLKVHLLTHSSSQGQ CCEEEEEECCCCCCC	26.52	30177828
296	Phosphorylation	KVHLLTHSSSQGQRP EEEEEECCCCCCCCC	26.84	30177828
297	Phosphorylation	VHLLTHSSSQGQRPF EEEEECCCCCCCCCE	21.05	30177828
298	Phosphorylation	HLLTHSSSQGQRPFK EEEECCCCCCCCCEE	41.15	30177828
347	Phosphorylation	GCGKSFTTVYNLKAH CCCCCEEEEEEHHHH	20.98	29759185
349	Phosphorylation	GKSFTTVYNLKAHMK CCCEEEEEEHHHHHC	16.82	29759185
427	Phosphorylation	EQELFSCSFPGCSKQ HHHHHCCCCCCCCHH	33.02	21815630
433	Ubiquitination	CSFPGCSKQYDKACR CCCCCCCHHHCCCCC	57.88	-
449	Phosphorylation	KIHLRSHTGERPFLC EEEECCCCCCCCEEC	41.82	21857030
493	Ubiquitination	CPVEGCGKSFTRAEH CCCCCCCCCCCCHHH	46.61	-
502	Ubiquitination	FTRAEHLKGHSITHL CCCHHHHCCCCCEEC	57.39	-
529	Phosphorylation	CARFSARSSLYIHSK HHHHHHHHCEEEEEC	25.14	27251275
530	Phosphorylation	ARFSARSSLYIHSKK HHHHHHHCEEEEECC	21.46	27251275
536	Ubiquitination	SSLYIHSKKHLQDVD HCEEEEECCCCCCHH	30.01	-
537	Ubiquitination	SLYIHSKKHLQDVDT CEEEEECCCCCCHHH	53.19	29967540
546	Ubiquitination	LQDVDTWKSRCPISS CCCHHHHHHCCCHHH	30.07	29967540
561	Sumoylation	CNKLFTSKHSMKTHM HHHHHHCCHHCHHHH	36.32	-
561	Sumoylation	CNKLFTSKHSMKTHM HHHHHHCCHHCHHHH	36.32	-
561	Ubiquitination	CNKLFTSKHSMKTHM HHHHHHCCHHCHHHH	36.32	-
587	Phosphorylation	AQLEAANSLTPSSEL HHHHHHHHCCCCHHH	28.97	27251275
717	Phosphorylation	DSLAMKNSSPEPQAL HHHHCCCCCCCCCCC	41.57	30266825
718	Phosphorylation	SLAMKNSSPEPQALT HHHCCCCCCCCCCCC	42.55	30266825
725	Phosphorylation	SPEPQALTPSSKLTV CCCCCCCCCCCCEEE	24.92	25159151
727	Phosphorylation	EPQALTPSSKLTVDT CCCCCCCCCCEEECC	34.56	22199227
728	Phosphorylation	PQALTPSSKLTVDTD CCCCCCCCCEEECCC	32.65	23090842
731	Phosphorylation	LTPSSKLTVDTDALT CCCCCCEEECCCCCC	21.77	28985074
734	Phosphorylation	SSKLTVDTDALTPSS CCCEEECCCCCCCCC	20.88	28985074
738	Phosphorylation	TVDTDALTPSSTLCE EECCCCCCCCCCCCC	23.89	29116813
740	Phosphorylation	DTDALTPSSTLCENS CCCCCCCCCCCCCCC	30.62	22210691
741	Phosphorylation	TDALTPSSTLCENSV CCCCCCCCCCCCCCH	26.97	27251275
742	Phosphorylation	DALTPSSTLCENSVS CCCCCCCCCCCCCHH	39.50	27251275
747	Phosphorylation	SSTLCENSVSELLTP CCCCCCCCHHHHCCC	12.53	27251275
749	Phosphorylation	TLCENSVSELLTPTK CCCCCCHHHHCCCCC	23.50	27251275
753	Phosphorylation	NSVSELLTPTKAEWN CCHHHHCCCCCCCCE	41.35	29116813
755	Phosphorylation	VSELLTPTKAEWNVH HHHHCCCCCCCCEEC	37.34	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZXDB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZXDB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZXDB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZXDB_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.