dbPTM

ZWINT_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZWINT_RAT
UniProt AC	Q8VIL3
Protein Name	ZW10 interactor
Gene Name	Zwint
Organism	Rattus norvegicus (Rat).
Sequence Length	266
Subcellular Localization	Nucleus. Chromosome, centromere, kinetochore. Localizes to kinetochores from late prophase to anaphase..
Protein Description	Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity)..
Protein Sequence	MADAEKNAVAEKNAVAEENAVAEENAVADKNATKEVLAEAASVLEPVGLPEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDNTDQNPDALASEDTSRQKATETKEQWKELKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISESKADDKDVKGPALPPKSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MADAEKNAVAEKN --CCHHHHHHHHHHH	52.51	22902405
124	Phosphorylation	QWKELKATYMDHVDV HHHHHHHHHHCHHHH	20.14	22276854
125	Phosphorylation	WKELKATYMDHVDVI HHHHHHHHHCHHHHH	12.85	-
163	Ubiquitination	AFEQLEAKKRVLEEK HHHHHHHHHHHHHHH	31.56	-
176	Ubiquitination	EKLQLAQKQWVLQQK HHHHHHHHHHHHHHH	40.29	-
209	Phosphorylation	ALEKLDGSHQELETL HHHHHCCCHHHHHHH	22.97	27097102
232	Phosphorylation	EKLQRNQSYLQLLCS HHHHHCHHHHHHHHH	31.21	28689409
233	Phosphorylation	KLQRNQSYLQLLCSL HHHHCHHHHHHHHHH	6.68	27097102
239	Phosphorylation	SYLQLLCSLQNKLVI HHHHHHHHHHCCCCC	32.72	27097102
265	Phosphorylation	GPALPPKSP------ CCCCCCCCC------	41.43	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZWINT_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZWINT_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZWINT_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZWINT_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZWINT_RAT

Related Literatures of Post-Translational Modification