dbPTM

ZUFSP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZUFSP_MOUSE
UniProt AC	Q3T9Z9
Protein Name	Ubiquitin carboxyl-terminal hydrolase ZUFSP
Gene Name	Zufsp
Organism	Mus musculus (Mouse).
Sequence Length	577
Subcellular Localization	Cytoplasm . Nucleus . Mostly present in the nuclear fraction. Localizes to DNA lesions.
Protein Description	Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress..
Protein Sequence	MLSCNICGETVNSEPDMKAHLIVHMENEIICPFCKLSGINYNEICFHIETVHFEQNAPEKNSEKLAAVQYGHSDRKNTNLQSTAEVTSGIHSACASSFPKESSESLPKDRTVKHEAFYTENITESRKYQKSREKKPGLSEAQGSIYETTYSPPECPFCGKIEGCSQDMEIHVKTKHASLLESPLKDCHQPLYDCPMCGLVCTNYHILQEHVDLHLEESSFQQGMDRVQCSSDRELAHRLQQEEDRKRKSEESRQEREEFQKLQRQYGLDNSGGYKQQQLRHMELEVNRGRMHPSEFHSRKADMLESIAIGIDDGKTKTSGIIEALHRYYQNTATDVRCVWLSTVVDHFHSSFGDKGWGCGYRNFQMLLSSLLQSDVYGDCLKGMAVPCIPKIQSMIEDAWNEGFDPQGASQLNNKLQGTKAWIGACEIYTLLTSLRVKCRIIDFHKSTGPLGTHPRLFEWILNYYSSETEGTPKIVCTSKPPIYLQHQGHSRTVVGIEEKKNRTLCLLVFDPGCPSREMQKLLKQDMEASSLRQLRKSVGNLKHKQYQIVAVEGVLSPEEKVARKQASQVFTAEKIP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of ZUFSP_MOUSE !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZUFSP_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZUFSP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZUFSP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZUFSP_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZUFSP_MOUSE

Related Literatures of Post-Translational Modification