ZPBP1_HUMAN - dbPTM
ZPBP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZPBP1_HUMAN
UniProt AC Q9BS86
Protein Name Zona pellucida-binding protein 1
Gene Name ZPBP
Organism Homo sapiens (Human).
Sequence Length 351
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Peripheral membrane protein . Secreted . First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.
Protein Description Plays a role in acrosome compaction and sperm morphogenesis. [PubMed: 21911476 Is implicated in sperm-oocyte interaction during fertilization (By similarity]
Protein Sequence MEAFALGPARRGRRRTRAAGSLLSRAAILLFISAFLVRVPSSVGHLVRLPRAFRLTKDSVKIVGSTSFPVKAYVMLHQKSPHVLCVTQQLRNAELIDPSFQWYGPKGKVVSVENRTAQITSTGSLVFQNFEESMSGIYTCFLEYKPTVEEIVKRLQLKYAIYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDTEKGPKRCTDHNCEPYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVICSPGSYNPRDGIHCLQCNSSLVYGAKTCL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationARRGRRRTRAAGSLL
CCCCHHHHHHHHHHH		23.8922210691
21PhosphorylationRRTRAAGSLLSRAAI
HHHHHHHHHHHHHHH		22.7824719451
24PhosphorylationRAAGSLLSRAAILLF
HHHHHHHHHHHHHHH		25.7624719451
42PhosphorylationFLVRVPSSVGHLVRL
HHHCCCCHHHHHHCC		26.5024114839
65PhosphorylationDSVKIVGSTSFPVKA
CCEEEEECCCCCEEE		15.2430622161
66PhosphorylationSVKIVGSTSFPVKAY
CEEEEECCCCCEEEE		28.5828787133
67PhosphorylationVKIVGSTSFPVKAYV
EEEEECCCCCEEEEE		29.2930622161
114N-linked_GlycosylationGKVVSVENRTAQITS
CCEEEEECCEEEEEC		44.43UniProtKB CARBOHYD
133PhosphorylationVFQNFEESMSGIYTC
EECCHHHHHCCEEEE		15.8522468782
138PhosphorylationEESMSGIYTCFLEYK
HHHHCCEEEEHHEEC		10.8622468782
139PhosphorylationESMSGIYTCFLEYKP
HHHCCEEEEHHEECC		8.5522468782
158AcetylationIVKRLQLKYAIYAYR
HHHHHCHHHHHEECC		21.4825038526
187N-linked_GlycosylationAPCNSIYNISFEKKL
CCCCCEEECCHHHHH		23.04UniProtKB CARBOHYD
199PhosphorylationKKLLQILSKLLLDLS
HHHHHHHHHHHHHHH		23.9224719451
210PhosphorylationLDLSCEISLLKSECH
HHHHHHHHHHHHHHH		12.8324719451
249PhosphorylationEKGPKRCTDHNCEPY
CCCCCCCCCCCCHHH		44.3124719451
324PhosphorylationPECCVICSPGSYNPR
CCCEEEECCCCCCCC		22.6029978859
328PhosphorylationVICSPGSYNPRDGIH
EEECCCCCCCCCCCE		34.7929978859
340N-linked_GlycosylationGIHCLQCNSSLVYGA
CCEEEECCCEEEEEC		22.98UniProtKB CARBOHYD
341PhosphorylationIHCLQCNSSLVYGAK
CEEEECCCEEEEECC		32.4529978859
342PhosphorylationHCLQCNSSLVYGAKT
EEEECCCEEEEECCC		14.0929978859
345PhosphorylationQCNSSLVYGAKTCL-
ECCCEEEEECCCCC-		19.3629978859
349PhosphorylationSLVYGAKTCL-----
EEEEECCCCC-----		20.6429978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZPBP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZPBP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZPBP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZPBP1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZPBP1_HUMAN

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Related Literatures of Post-Translational Modification

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