ZN746_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN746_MOUSE
• UniProt AC: Q3U133
• Protein Name: Zinc finger protein 746
• Gene Name: Znf746
• Organism: Mus musculus (Mouse).
• Sequence Length: 652
• Subcellular Localization: Cytoplasm. Nucleus. Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes..
• Protein Description: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death..
• Protein Sequence: MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEVPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCTWRRTGPKVPEVPVDPSPGSGAPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQADLPPHHPSSACSDGTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFAPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPTRPERDIGELSPAIAQEEAPAGDWLFGGVRWGWNFRCKPPVGLNPRTVPEGLPFSSPDNGEAILDPSQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGLSDGAATGAASTTTGGGGGGSGGGGGSSGGGSSARDSSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHPAVAKAPAHGQPLPPLPAPPDPFKSPAAKGPMASTDLVTDWTCGLSVLGPSDGGGDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EAAAAPISPWTMAAT CHHCCCCCHHHHHHH	17.21	24719451
298	Phosphorylation	QEEEVVATPVHPTDL CCEEEEECCCCCCCH	17.77	29514104
323	Phosphorylation	QATRFFPSPVQEGAW CCCEECCCCCCCCCH	32.33	21189417
360	Phosphorylation	ERDIGELSPAIAQEE CCCHHHCCHHHHCCC	14.16	27180971
387	Acetylation	WGWNFRCKPPVGLNP CEEECEECCCCCCCC	48.37	30988577
438	Acetylation	RTKGFGHKPGLKKHP CCCCCCCCCCCCCCC	40.95	23806337
505	Phosphorylation	SGGGGGSSGGGSSAR CCCCCCCCCCCCCCC	44.74	24224561
509	Phosphorylation	GGSSGGGSSARDSSA CCCCCCCCCCCCCCC	24.89	24224561
620	Phosphorylation	APPDPFKSPAAKGPM CCCCCCCCCCCCCCC	21.83	23608596

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN746_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN746_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN746_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN746_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.