ZN658_HUMAN - dbPTM
ZN658_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN658_HUMAN
UniProt AC Q5TYW1
Protein Name Zinc finger protein 658
Gene Name ZNF658
Organism Homo sapiens (Human).
Sequence Length 1059
Subcellular Localization Nucleus .
Protein Description Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply..
Protein Sequence MNMSQASVSFQDVTVEFTREEWQHLGPVERTLYRDVMLENYSHLISVGYCITKPKVISKLEKGEEPWSLEDEFLNQRYPGYFKVDHIKGIREKQEKPLWQEIFISDADKTLSKEGQKVLEKPFNLEIAPELSEKISCKCDSHRMNLPVASQLIISERKYSRKKTEYMNVCEKLQLDIKHEKAHAEEKSYEHGENAKAFSYKKDQHWKFQTLEESFECDGSGQGLYDKTICITPQSFLTGEKSCKDDEFRKNFDKITLFNHMRTDTRGKCSDLNEYGTSCDKTTAVEYNKVHMAMTHYECNERGINFSRKSPLTQSQRTITGWSAFESNKCEENFSQSSAHIVHQKTQAGDKFGEHNECTDALYQKLDFTAHQRIHTEDKFYLSDEHGKCRKSFYRKAHLIQHQRPHSGEKTYQYEECAKSFCSSSHPIQHPGTYVGFKLYECNECGKAFCQNSNLSKHLRIHTKEKPCDNNGCGRSYKSPLIGHQKTDAEMELCGGSEYGKTSHLKGHQRILMGEKPYECIECGKTFSKTSHLRAHQRIHTGEKPYECVECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEKPYECSDCEKTFAHNSALRAHHRIHTGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYECNECGRSFTYNSALRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQRIHTGEKPYECNECEKTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFSQKSYLSGHERIHTGEKPYECNVCGKTFVYKAALIVHQRIHTGEKPYECNQCGKTFSQRTHLCAHQRIHTGEKPYECNECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAHLRTRSGEKPYECSECGKTFSEKSYVSAHQRVHTGEKPYECNVCGKPFAHNSTLRVHQRIHTGEKSYECNDCGKTFSQKSHLSAHQRIHTGEKPYECNECGKAFAQNSTLRVHQRIHTGEKPYECDECGKTFVRKAALRVHHTRMHTREKTLACNGFGKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53AcetylationSVGYCITKPKVISKL
EEEEEECCHHHHHHC		23.9519824919
62AcetylationKVISKLEKGEEPWSL
HHHHHCCCCCCCCCC		80.3019824925
121UbiquitinationEGQKVLEKPFNLEIA
HHHHHHHCCCCCCCC		51.23-
134SumoylationIAPELSEKISCKCDS
CCHHHHHHHCCCCCH		36.22-
164PhosphorylationRKYSRKKTEYMNVCE
CCCCCCCHHHHHHHH		35.0730242111
166PhosphorylationYSRKKTEYMNVCEKL
CCCCCHHHHHHHHHH		10.1430242111
178SumoylationEKLQLDIKHEKAHAE
HHHHCHHHHHHHHHH		45.4328112733
210PhosphorylationDQHWKFQTLEESFEC
CCCCEEEEHHHHCCC		38.9922210691
214PhosphorylationKFQTLEESFECDGSG
EEEEHHHHCCCCCCC		19.5728348404
228PhosphorylationGQGLYDKTICITPQS
CCCCCCCEEEECCHH		20.41-
232PhosphorylationYDKTICITPQSFLTG
CCCEEEECCHHHHCC		15.74-
235PhosphorylationTICITPQSFLTGEKS
EEEECCHHHHCCCCC		24.3522210691
238PhosphorylationITPQSFLTGEKSCKD
ECCHHHHCCCCCCCC		41.0822210691
275PhosphorylationKCSDLNEYGTSCDKT
CCCCHHHHCCCCCCC		25.32-
277PhosphorylationSDLNEYGTSCDKTTA
CCHHHHCCCCCCCCC		25.86-
420PhosphorylationQYEECAKSFCSSSHP
CHHHHHHHHHHCCCC		16.9830576142
423PhosphorylationECAKSFCSSSHPIQH
HHHHHHHHCCCCCCC		32.6330576142
434PhosphorylationPIQHPGTYVGFKLYE
CCCCCCCEEEEEEEE		12.4230576142
541PhosphorylationRAHQRIHTGEKPYEC
HHHCEECCCCCCEEE		44.6728111955
569PhosphorylationSVHQRVHTGEKPYEC
EEECCCCCCCCCEEC		44.15-
597PhosphorylationRAHQRIHTGEKPYEC
HHHHHHHCCCCCCCC		44.6728111955
610 (in isoform 2)Phosphorylation-12.0823879269
612 (in isoform 2)Phosphorylation-13.2423879269
617 (in isoform 2)Phosphorylation-5.0923879269
625PhosphorylationRAHHRIHTGEKPYEC
HHHHCCCCCCCCEEC		44.6728655764
653PhosphorylationKAHQRIHTGEKPYEC
HHHHCCCCCCCCEEC		44.6728655764
656UbiquitinationQRIHTGEKPYECNEC
HCCCCCCCCEECCCC		55.00-
709PhosphorylationKIHQRIHTGEKPYEC
HHHHHHHCCCCCCCC		44.6728655764
712UbiquitinationQRIHTGEKPYECNEC
HHHHCCCCCCCCCHH		55.00-
765PhosphorylationSTHRRIHTGEKPYEC
CCCCCCCCCCCCCCC		44.6728111955
780PhosphorylationSKCGKTFSQKSYLSG
CCCCCCCCCCCCCCC		41.76-
793PhosphorylationSGHERIHTGEKPYEC
CCCCCCCCCCCCEEC		44.6728111955
821PhosphorylationIVHQRIHTGEKPYEC
EEHHHCCCCCCCEEC		44.6727282143
824UbiquitinationQRIHTGEKPYECNQC
HHCCCCCCCEECCCC		55.00-
849PhosphorylationCAHQRIHTGEKPYEC
CCCCCCCCCCCCEEC		44.6728152594
852UbiquitinationQRIHTGEKPYECNEC
CCCCCCCCCEECCCC		55.00-
854PhosphorylationIHTGEKPYECNECGK
CCCCCCCEECCCCCC		44.1528152594
877PhosphorylationRAHHRIHTGEKPYEC
HHHHCCCCCCCCEEC		44.6728111955
913PhosphorylationGEKPYECSECGKTFS
CCCCEECCCCCCCCC		24.79-
933PhosphorylationSAHQRVHTGEKPYEC
CHHHHCCCCCCCEEE		44.15-
989PhosphorylationSAHQRIHTGEKPYEC
CHHHHHHCCCCCEEC		44.6728152594
992UbiquitinationQRIHTGEKPYECNEC
HHHHCCCCCEECCHH		55.00-
994PhosphorylationIHTGEKPYECNECGK
HHCCCCCEECCHHHH		44.1528152594
1017PhosphorylationRVHQRIHTGEKPYEC
EEEEECCCCCCCEEC		44.6725159151
1042PhosphorylationAALRVHHTRMHTREK
HHHHHHHHCCCCCCC		18.1423403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN658_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN658_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN658_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN658_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN658_HUMAN

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Related Literatures of Post-Translational Modification

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