dbPTM

ZN532_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN532_HUMAN
UniProt AC	Q9HCE3
Protein Name	Zinc finger protein 532
Gene Name	ZNF532
Organism	Homo sapiens (Human).
Sequence Length	1301
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTGNGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQKTCTICQMLLPNQCSYASHQRIHQHKSPYTCPECGAICRSVHFQTHVTKNCLHYTRRVGFRCVHCNVVYSDVAALKSHIQGSHCEVFYKCPICPMAFKSAPSTHSHAYTQHPGIKIGEPKIIYKCSMCDTVFTLQTLLYRHFDQHIENQKVSVFKCPDCSLLYAQKQLMMDHIKSMHGTLKSIEGPPNLGINLPLSIKPATQNSANQNKEDTKSMNGKEKLEKKSPSPVKKSMETKKVASPGWTCWECDCLFMQRDVYISHVRKEHGKQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACSHCPDSRRTFTKRLMLEKHVQLMHGIKDPDLKEMTDATNEEETEIKEDTKVPSPKRKLEEPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHKSDGSSYQCRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGEDNQQENKPSHEDESPDGAVSDRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MTMGDMKTPDFDDLL CCCCCCCCCCHHHHH	22.81	-
120	Phosphorylation	DVPASEVTLKDSTFS CCCHHEEEECCCCCC	24.84	22210691
124	Phosphorylation	SEVTLKDSTFSQFSP HEEEECCCCCCCCCC	29.75	21406692
125	Phosphorylation	EVTLKDSTFSQFSPI EEEECCCCCCCCCCC	37.12	21406692
127	Phosphorylation	TLKDSTFSQFSPISS EECCCCCCCCCCCCC	30.33	21406692
130	Phosphorylation	DSTFSQFSPISSAEE CCCCCCCCCCCCCCC	17.43	22777824
133	Phosphorylation	FSQFSPISSAEEFDD CCCCCCCCCCCCCCC	27.21	21406692
134	Phosphorylation	SQFSPISSAEEFDDD CCCCCCCCCCCCCCC	40.18	21406692
158	Phosphorylation	DKEDMRSSFRSNVLT CHHHHHHHHHHCCCC	17.83	17081983
173	Phosphorylation	GSAPQQDYDKLKALG CCCCHHHHHHHHHHC	15.61	27642862
175	Acetylation	APQQDYDKLKALGGE CCHHHHHHHHHHCCC	45.73	23236377
187	Phosphorylation	GGENSSKTGLSTSGN CCCCCCCCCCCCCCC	45.35	-
190	Phosphorylation	NSSKTGLSTSGNVEK CCCCCCCCCCCCHHH	23.13	23312004
191	Phosphorylation	SSKTGLSTSGNVEKN CCCCCCCCCCCHHHC	45.77	24719451
192	Phosphorylation	SKTGLSTSGNVEKNK CCCCCCCCCCHHHCC	25.62	25159151
205	Phosphorylation	NKAVKRETEASSINL CCCCCCCCCCCCCCC	40.67	18669648
245	Phosphorylation	RVLDGKLSSEKNDTS HHHCCCCCCCCCCCC	39.68	29514088
246	Phosphorylation	VLDGKLSSEKNDTSL HHCCCCCCCCCCCCC	64.13	29514088
248	Ubiquitination	DGKLSSEKNDTSLPS CCCCCCCCCCCCCCC	63.17	20972266
251	Phosphorylation	LSSEKNDTSLPSVAP CCCCCCCCCCCCCCC	41.37	28387310
252	Phosphorylation	SSEKNDTSLPSVAPS CCCCCCCCCCCCCCC	40.94	25159151
255	Phosphorylation	KNDTSLPSVAPSKTK CCCCCCCCCCCCCCC	35.88	21406692
259	Phosphorylation	SLPSVAPSKTKSSSK CCCCCCCCCCCCCHH	43.13	21406692
260	Methylation	LPSVAPSKTKSSSKL CCCCCCCCCCCCHHH	59.94	115978147
262	Methylation	SVAPSKTKSSSKLSS CCCCCCCCCCHHHHH	52.67	115978153
263	Phosphorylation	VAPSKTKSSSKLSSC CCCCCCCCCHHHHHH	45.11	17287340
268	Phosphorylation	TKSSSKLSSCIAAIA CCCCHHHHHHHHHHH	27.22	17287340
269	Phosphorylation	KSSSKLSSCIAAIAA CCCHHHHHHHHHHHH	21.70	17287340
284	Phosphorylation	LSAKKAASDSCKEPV HHHHHHCCCCCCCCC	34.61	21406692
286	Phosphorylation	AKKAASDSCKEPVAN HHHHCCCCCCCCCCC	25.29	30576142
294	Phosphorylation	CKEPVANSRESSPLP CCCCCCCCCCCCCCC	27.90	25159151
297	Phosphorylation	PVANSRESSPLPKEV CCCCCCCCCCCCCCC	35.82	30266825
298	Phosphorylation	VANSRESSPLPKEVN CCCCCCCCCCCCCCC	26.21	30266825
307	Phosphorylation	LPKEVNDSPRAADKS CCCCCCCCCCCCCCC	15.87	25159151
314	Phosphorylation	SPRAADKSPESQNLI CCCCCCCCHHHHCCC	34.15	30266825
317	Phosphorylation	AADKSPESQNLIDGT CCCCCHHHHCCCCCC	27.96	30266825
324	Phosphorylation	SQNLIDGTKKPSLKQ HHCCCCCCCCCCCCC	31.95	28192239
328	Phosphorylation	IDGTKKPSLKQPDSP CCCCCCCCCCCCCCC	58.01	27251275
334	Phosphorylation	PSLKQPDSPRSISSE CCCCCCCCCCCCCCC	28.97	28985074
337	Phosphorylation	KQPDSPRSISSENSS CCCCCCCCCCCCCCC	30.15	30177828
339	Phosphorylation	PDSPRSISSENSSKG CCCCCCCCCCCCCCC	32.61	30177828
340	Phosphorylation	DSPRSISSENSSKGS CCCCCCCCCCCCCCC	38.84	30177828
343	Phosphorylation	RSISSENSSKGSPSS CCCCCCCCCCCCCCC	29.40	30177828
344	Phosphorylation	SISSENSSKGSPSSP CCCCCCCCCCCCCCC	53.25	30177828
347	Phosphorylation	SENSSKGSPSSPAGS CCCCCCCCCCCCCCC	25.91	30266825
349	Phosphorylation	NSSKGSPSSPAGSTP CCCCCCCCCCCCCCC	51.13	30266825
350	Phosphorylation	SSKGSPSSPAGSTPA CCCCCCCCCCCCCCC	23.35	30266825
354	Phosphorylation	SPSSPAGSTPAIPKV CCCCCCCCCCCCCEE	33.07	23663014
355	Phosphorylation	PSSPAGSTPAIPKVR CCCCCCCCCCCCEEE	18.80	23663014
368	Phosphorylation	VRIKTIKTSSGEIKR EEEEEEECCCCCCEE	25.03	25159151
369	Phosphorylation	RIKTIKTSSGEIKRT EEEEEECCCCCCEEE	31.20	25159151
370	Phosphorylation	IKTIKTSSGEIKRTV EEEEECCCCCCEEEE	45.75	25159151
388	Phosphorylation	LPEVDLDSGKKPSEQ CCCCCCCCCCCCCHH	60.86	21815630
404	Phosphorylation	ASVMASVTSLLSSPA HHHHHHHHHHHCCCC	15.91	28348404
405	Phosphorylation	SVMASVTSLLSSPAS HHHHHHHHHHCCCCC	25.76	28348404
408	Phosphorylation	ASVTSLLSSPASAAV HHHHHHHCCCCCHHH	39.30	28348404
409	Phosphorylation	SVTSLLSSPASAAVL HHHHHHCCCCCHHHH	25.18	28348404
412	Phosphorylation	SLLSSPASAAVLSSP HHHCCCCCHHHHCCC	21.83	29255136
417	Phosphorylation	PASAAVLSSPPRAPL CCCHHHHCCCCCCCC	33.91	29255136
418	Phosphorylation	ASAAVLSSPPRAPLQ CCHHHHCCCCCCCCC	34.46	29255136
426	Phosphorylation	PPRAPLQSAVVTNAV CCCCCCCEEEECCCC	30.62	27732954
430	Phosphorylation	PLQSAVVTNAVSPAE CCCEEEECCCCCHHH	15.74	30266825
434	Phosphorylation	AVVTNAVSPAELTPK EEECCCCCHHHCCCC	18.91	30266825
439	Phosphorylation	AVSPAELTPKQVTIK CCCHHHCCCCEEEEE	21.68	30266825
456	Phosphorylation	ATAFLPVSAVKTAGS EEEECCHHHEEECCC	25.96	25159151
456	O-linked_Glycosylation	ATAFLPVSAVKTAGS EEEECCHHHEEECCC	25.96	30379171
459	Sumoylation	FLPVSAVKTAGSQVI ECCHHHEEECCCEEE	32.16	28112733
463	Phosphorylation	SAVKTAGSQVINLKL HHEEECCCEEEEEEE	20.86	-
474	Phosphorylation	NLKLANNTTVKATVI EEEECCCCEEEEEEE	32.54	-
475	Phosphorylation	LKLANNTTVKATVIS EEECCCCEEEEEEEE	23.33	-
482	O-linked_Glycosylation	TVKATVISAASVQSA EEEEEEEEHHHHHCH	17.28	30379171
516	Sumoylation	ASSLANAKLVPKTVH HHHHHCCCCCCCEEE	50.23	28112733
546	Ubiquitination	ELRQVLTKPQQQIKQ HHHHHHCCHHHHHHH	36.35	-
575	Phosphorylation	SRVQVVSSLQSSVVE CEEHHHHHHHHHHHH	20.86	-
589	Phosphorylation	EAFNKVLSSVNPVPV HHHHHHHHCCCCCCE	34.92	21406692
590	Phosphorylation	AFNKVLSSVNPVPVY HHHHHHHCCCCCCEE	23.04	21406692
597	Phosphorylation	SVNPVPVYIPNLSPP CCCCCCEECCCCCCC	12.46	25850435
602	Phosphorylation	PVYIPNLSPPANAGI CEECCCCCCCCCCCC	35.16	25850435
610	Phosphorylation	PPANAGITLPTRGYK CCCCCCCCCCCCCEE	26.26	25850435
613	Phosphorylation	NAGITLPTRGYKCLE CCCCCCCCCCEEEEC	39.58	25850435
811	Phosphorylation	IHQHKSPYTCPECGA HHCCCCCCCCCCHHH	28.23	-
890	Phosphorylation	PSTHSHAYTQHPGIK CCCCCCCCCCCCCCC	11.08	28064214
980	Sumoylation	INLPLSIKPATQNSA CCCCEEECCCCCCCC	25.81	28112733
994	Phosphorylation	ANQNKEDTKSMNGKE CCCCHHHHHHCCHHH	26.55	-
1007	Phosphorylation	KEKLEKKSPSPVKKS HHHHHHCCCCCCCHH	41.50	30576142
1009	Phosphorylation	KLEKKSPSPVKKSME HHHHCCCCCCCHHHC	49.79	30576142
1017	Phosphorylation	PVKKSMETKKVASPG CCCHHHCCCCCCCCC	27.76	-
1022	Phosphorylation	METKKVASPGWTCWE HCCCCCCCCCCCHHH	27.25	24719451
1067	Phosphorylation	CDKSFSSSHSLCRHN CCCCCCCCCHHHHCC	18.85	25627689
1069	Phosphorylation	KSFSSSHSLCRHNRI CCCCCCCHHHHCCCC	30.98	25159151
1125	Phosphorylation	LKEMTDATNEEETEI HHHHCCCCCHHHHHH	46.07	23186163
1130	Phosphorylation	DATNEEETEIKEDTK CCCCHHHHHHCCCCC	46.41	29523821
1136	Phosphorylation	ETEIKEDTKVPSPKR HHHHCCCCCCCCCCC	34.72	30266825
1140	Phosphorylation	KEDTKVPSPKRKLEE CCCCCCCCCCCCCCC	46.14	30266825
1144	Sumoylation	KVPSPKRKLEEPVLE CCCCCCCCCCCCCCC	67.39	28112733
1167	Ubiquitination	TQPLKKLKINVFKVH CCCHHHCCCEEEEEE	40.91	-
1167	Sumoylation	TQPLKKLKINVFKVH CCCHHHCCCEEEEEE	40.91	28112733
1219	Phosphorylation	YTSHVSLSRHLFIVH CCCCCEECCEEEEEE	15.33	24719451
1251	Phosphorylation	NQQENKPSHEDESPD CCCCCCCCCCCCCCC	40.91	21406692
1256	Phosphorylation	KPSHEDESPDGAVSD CCCCCCCCCCCCCCC	40.38	21406692
1262	Phosphorylation	ESPDGAVSDRKCKVC CCCCCCCCCCCCCEE	31.03	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN532_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN532_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN532_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZN532_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN532_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-268 ANDSER-269, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-133 ANDSER-134, AND MASS SPECTROMETRY.	17081983 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205, AND MASSSPECTROMETRY.	18669648 [Abstract]