ZN521_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN521_MOUSE
• UniProt AC: Q6KAS7
• Protein Name: Zinc finger protein 521
• Gene Name: Znf521
• Organism: Mus musculus (Mouse).
• Sequence Length: 1311
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes..
• Protein Sequence: MSRRKQAKPRSLKDPNCKLEDKIEDGEAVDCKKRPEDGEELEEDAVHSCDSCLQVFESLSDITEHKIHQCQLTDGVDVEDDPSCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCMYCHELFVEETSLMNHIEQVHGGEKKNSCSICSESFLTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTSDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEAELQTLLTNSQESHNSHDGSEEDVDSSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSSVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSSSPGLSLPPGASRPGLGQNESLSAMEGKGKAGGLKTRCSSCNVKFESESELQNHIQTVHRELVPDANSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	SCSWPASSPSSKDQT CCCCCCCCCCCCCCC	30.79	25338131
273	Phosphorylation	AECHPECSPNEDRAA HHHCCCCCCCHHHHH	29.15	25619855
546	Phosphorylation	LSGSRFGSPVLGTPK CCCCCCCCCCCCCCC	14.77	24925903
551	Phosphorylation	FGSPVLGTPKEPVVE CCCCCCCCCCCCEEE	27.33	29472430
601	Phosphorylation	YIHNGKKSRALSPLS HHHCCCCCCCCCCCC	26.69	29550500
605	Phosphorylation	GKKSRALSPLSPVAI CCCCCCCCCCCCCEE	23.86	24925903
608	Phosphorylation	SRALSPLSPVAIEQT CCCCCCCCCCEEHHH	22.25	24925903
615	Phosphorylation	SPVAIEQTTLKMMQT CCCEEHHHHHHHHHH	22.70	25777480
616	Phosphorylation	PVAIEQTTLKMMQTV CCEEHHHHHHHHHHC	24.87	25777480
1104	Phosphorylation	VNLSKSSSPGLSLPP EECCCCCCCCCCCCC	30.03	25338131
1137	Acetylation	KGKAGGLKTRCSSCN CCCCCCCCCCCCCCC	36.88	6571505
1175	Phosphorylation	ANSTQLKTPQVSPMP CCCCCCCCCCCCCCC	27.78	23527152
1179	Phosphorylation	QLKTPQVSPMPRISP CCCCCCCCCCCCCCC	15.38	23527152
1185	Phosphorylation	VSPMPRISPSQSDEK CCCCCCCCCCCCCCH	21.56	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN521_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN521_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN521_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUNX2_MOUSE	Runx2	physical	21173110
HDAC9_HUMAN	HDAC9	physical	21173110
MTA2_HUMAN	MTA2	physical	21173110

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.