ZN468_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN468_HUMAN
• UniProt AC: Q5VIY5
• Protein Name: Zinc finger protein 468
• Gene Name: ZNF468
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMLKTLSSTGQGNTEVIHTGTLHRQASHHIGEFCFHEIEKDIHGFEFQWKEDETNGHAAPMTEIKELAGSTGQHDQRHAGNKRIKDQLGSSFHLHLPEPHIFQSEGKIGNQVEKSINNASSVSTSQRICCRPKTHISNKYGNNSLHSSLLTQKWEVHMREKSFECIQSFKSFNCSSLLKKHQIIHLEEKQCKCDVCGKVFNQKRYLACHRRCHTGEKPYKCNECGKTFGHNSSLFIHKALHTGEKPYECEECDKVFSRKSHLERHKRIHTGEKPYKCKVCDEAFAYNSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARHHRLHTGEKPYKCEECDKVFSRKSHLERHRRIHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKPYKCKVCDKAFQRDSHLAQHQRVHTGEKPYKCNECGKTFGQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	RDVAIEFSQEEWKCL HHHHHCCCHHHHHHC	24.72	27251275
23	Ubiquitination	EFSQEEWKCLDPAQR CCCHHHHHHCCHHHH	28.35	-
41	Phosphorylation	RDVMLENYRNLVSLD HHHHHHHHHHCEECC	7.48	22210691
46	Phosphorylation	ENYRNLVSLDISSKC HHHHHCEECCCCCCH	24.40	22210691
79	Phosphorylation	GTLHRQASHHIGEFC CEECCCCCHHHHCHH	13.78	-
113 (in isoform 2)	Ubiquitination	-	4.50	21890473
142	Phosphorylation	RIKDQLGSSFHLHLP HHHHHHCCCEEEECC	38.12	28555341
166	Ubiquitination	KIGNQVEKSINNASS CHHHHHHHHHHCCCC	58.75	-
166 (in isoform 1)	Ubiquitination	-	58.75	21890473
167	Phosphorylation	IGNQVEKSINNASSV HHHHHHHHHHCCCCC	19.62	28555341
186	Phosphorylation	RICCRPKTHISNKYG EEEECCCCCCCCCCC	27.42	26552605
189	Phosphorylation	CRPKTHISNKYGNNS ECCCCCCCCCCCCCC	21.47	26552605
191	Ubiquitination	PKTHISNKYGNNSLH CCCCCCCCCCCCCHH	47.98	-
192	Phosphorylation	KTHISNKYGNNSLHS CCCCCCCCCCCCHHH	29.36	26552605
196	Phosphorylation	SNKYGNNSLHSSLLT CCCCCCCCHHHHHHH	31.30	26552605
199	Phosphorylation	YGNNSLHSSLLTQKW CCCCCHHHHHHHHCC	28.16	26552605
200	Phosphorylation	GNNSLHSSLLTQKWE CCCCHHHHHHHHCCE	19.36	26552605
203	Phosphorylation	SLHSSLLTQKWEVHM CHHHHHHHHCCEEEE	33.14	26552605
223	Phosphorylation	ECIQSFKSFNCSSLL HHHHHHHCCCHHHHH	21.49	29970186
228	Phosphorylation	FKSFNCSSLLKKHQI HHCCCHHHHHHHHCE	39.66	24719451
250	Ubiquitination	CKCDVCGKVFNQKRY CCCCCCHHHHCCHHH	38.23	-
272	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
272	Ubiquitination	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
272	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
297	Ubiquitination	KALHTGEKPYECEEC HHHCCCCCCCCCHHH	55.00	-
322	Phosphorylation	ERHKRIHTGEKPYKC HHHHCCCCCCCCCCC	44.67	29496963
328 (in isoform 2)	Ubiquitination	-	35.79	21890473
328	Ubiquitination	HTGEKPYKCKVCDEA CCCCCCCCCCCCCCH	35.79	21890473
328	Ubiquitination	HTGEKPYKCKVCDEA CCCCCCCCCCCCCCH	35.79	21890473
330	Ubiquitination	GEKPYKCKVCDEAFA CCCCCCCCCCCCHHH	41.57	-
350	Phosphorylation	AKHTILHTGEKPYTC HHCCEEECCCCCEEC	43.52	21857030
353	Ubiquitination	TILHTGEKPYTCNEC CEEECCCCCEECCHH	44.67	-
368	Phosphorylation	GKVFNRLSTLARHHR HHHHHHHHHHHHHCC	20.38	24945436
378	Phosphorylation	ARHHRLHTGEKPYKC HHHCCCCCCCCCCCC	52.18	27422710
381	Sumoylation	HRLHTGEKPYKCEEC CCCCCCCCCCCCHHC	55.80	-
381	Sumoylation	HRLHTGEKPYKCEEC CCCCCCCCCCCCHHC	55.80	-
381	Ubiquitination	HRLHTGEKPYKCEEC CCCCCCCCCCCCHHC	55.80	21890473
381 (in isoform 1)	Ubiquitination	-	55.80	21890473
384	Sumoylation	HTGEKPYKCEECDKV CCCCCCCCCHHCHHH	43.63	-
384	Sumoylation	HTGEKPYKCEECDKV CCCCCCCCCHHCHHH	43.63	-
384	Ubiquitination	HTGEKPYKCEECDKV CCCCCCCCCHHCHHH	43.63	-
400	Ubiquitination	SRKSHLERHRRIHSG CCHHHHHHHHHHCCC	34.67	21890473
406	Phosphorylation	ERHRRIHSGEKPYKC HHHHHHCCCCCCCCH	46.40	29496963
412	Ubiquitination	HSGEKPYKCEECCKV CCCCCCCCHHHHHHH	43.63	-
434	Phosphorylation	ERHRRIHTGEKPYKC HHHHHCCCCCCCCCC	44.67	29496963
439	Phosphorylation	IHTGEKPYKCKVCDK CCCCCCCCCCCCCCH	39.83	-
440	Ubiquitination	HTGEKPYKCKVCDKA CCCCCCCCCCCCCHH	35.79	21890473
462	Phosphorylation	AQHQRVHTGEKPYKC HHHCCCCCCCCCEEC	44.15	29496963
465	Sumoylation	QRVHTGEKPYKCNEC CCCCCCCCCEECCCC	55.80	-
465	Ubiquitination	QRVHTGEKPYKCNEC CCCCCCCCCEECCCC	55.80	-
465	Sumoylation	QRVHTGEKPYKCNEC CCCCCCCCCEECCCC	55.80	-
468	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
468	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
468	Ubiquitination	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
490	Phosphorylation	IIHRRLHTGEKPYKC EEEEECCCCCCCEEC	52.18	27422710
493	Sumoylation	RRLHTGEKPYKCNEC EECCCCCCCEECCCC	55.80	-
493	Ubiquitination	RRLHTGEKPYKCNEC EECCCCCCCEECCCC	55.80	21890473
493	Sumoylation	RRLHTGEKPYKCNEC EECCCCCCCEECCCC	55.80	-
495	Phosphorylation	LHTGEKPYKCNECGK CCCCCCCEECCCCCC	38.96	-
496	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
496	Ubiquitination	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
496	Sumoylation	HTGEKPYKCNECGKT CCCCCCEECCCCCCC	38.83	-
512	Ubiquitination	SQMSSLVYHHRLHSG HHHHHHHHHHHCCCC	9.37	21890473
518	Phosphorylation	VYHHRLHSGEKP--- HHHHHCCCCCCC---	53.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN468_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN468_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN468_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN468_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.