ZN451_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN451_MOUSE
• UniProt AC: Q8C0P7
• Protein Name: E3 SUMO-protein ligase ZNF451 {ECO:0000305|PubMed:26524493}
• Gene Name: Znf451
• Organism: Mus musculus (Mouse).
• Sequence Length: 1056
• Subcellular Localization: Nucleus . Nucleus, PML body . Nucleus, nucleoplasm . Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location.
• Protein Description: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1. [PubMed: 26524493 Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets (By similarity]
• Protein Sequence: MGDPGPEIIESVPPAGPEASESTTDENEDDIQFVSEGPLRPVLEYIDLVSSDDEEPSTSHSDENFKCKDYIDHQKDKVALTLARLARHVEVEKQQKEEKNRAFREKIDFQHAHGLQELEFIQGHSETEAARQCVDQWLKMPGLRTNAANSGTKRSFQRGGRMWRSEKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPLANSFACAVCYEHFVTQQQYKDHLLSRTAAADGHSNSLLPQIIQCYACPQCFLLFSTKDECLKHMSTKNHFHQSFKLSDNKGTARPISFPSFAKKRLVSLCKDVPFQVKCVACHQTLRSHMELTAHFRVRCQNAGPVAIAEKSITQVAKEFIVRGYCSDCNQVFMDVASTQSHKNSGHKITLANSVEESVLLYCHISEGSRPPCDLHLFSQPKISSLKRILSVKESSAEDCIVPTKKVNLGVESLGGATRVQRQSPAVTAWFCECRRQFPSEEAVEKHVFSANTMCYKCVVCGKVCEDSGVMRLHMSRFHGGAHLNNFLFWCRTCKKELVKKDAIMAHITEFHSGHRYFYEMDEVEEEEEEAMPSSSVESHLNTDKPPSPIAVVDHCPANSPPRGRWQCRICEDMFESQECVKQHCMSLTSHRFHRYSCAHCRKTFHKVETLYRHCQDEHDSEIMMKYFCGLCDLIFNKEEEFLSHYKEHHSIDYVFVSEKTKTSIKTEGDFKIVETSSLLSCGCHESYMCKINRKEDYDRCLPVLLEKGRLWFRCSSCSATAQNVTDINTHVCQVHRKEKSEEEQQYVIKCGICTKAFQNTESAQQHFHRKHAALQKPTATPGGANRSSTCQLAASASHAEKNLKQPSSQKHSDVEKGAEHDVRCQNIEEEVELPDVDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTNWKPPLSCKVYNYLSRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDSSGMKGSPAEELRATEDVELEEAIRRSLEEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	PLRPVLEYIDLVSSD CCCCCCHHEEECCCC	8.79	21149613
50	Phosphorylation	LEYIDLVSSDDEEPS CHHEEECCCCCCCCC	35.03	21149613
51	Phosphorylation	EYIDLVSSDDEEPST HHEEECCCCCCCCCC	41.42	21149613
59	Phosphorylation	DDEEPSTSHSDENFK CCCCCCCCCCCCCCC	25.90	21149613
155	Phosphorylation	ANSGTKRSFQRGGRM CCCCCCCCHHHCCCC	27.56	-
158	Methylation	GTKRSFQRGGRMWRS CCCCCHHHCCCCCCC	47.74	-
302	Ubiquitination	SFPSFAKKRLVSLCK CCHHHHHHHHHHHHC	47.75	-
309	Ubiquitination	KRLVSLCKDVPFQVK HHHHHHHCCCCCEEE	68.03	-
422	Phosphorylation	LFSQPKISSLKRILS ECCCCCHHHHHHHHC	35.43	24719451
429	Phosphorylation	SSLKRILSVKESSAE HHHHHHHCCCCCCCC	28.86	22942356
586	Phosphorylation	LNTDKPPSPIAVVDH CCCCCCCCCEEEEEC	37.15	22006019
598	Phosphorylation	VDHCPANSPPRGRWQ EECCCCCCCCCCCCC	38.09	22006019
704	Ubiquitination	EKTKTSIKTEGDFKI CCCCCCCCCCCCEEE	40.05	-
725	Phosphorylation	LSCGCHESYMCKINR CCCCCCHHHEECCCC	8.42	-
726	Phosphorylation	SCGCHESYMCKINRK CCCCCHHHEECCCCH	11.98	-
817	Phosphorylation	HAALQKPTATPGGAN HHHHCCCCCCCCCCC	50.64	26239621
819	Phosphorylation	ALQKPTATPGGANRS HHCCCCCCCCCCCCC	25.58	25338131
1023	Phosphorylation	DTTKECDSDDSSGMK CCCCCCCCCCCCCCC	55.78	21149613
1026	Phosphorylation	KECDSDDSSGMKGSP CCCCCCCCCCCCCCH	33.51	21149613
1027	Phosphorylation	ECDSDDSSGMKGSPA CCCCCCCCCCCCCHH	50.31	21149613
1032	Phosphorylation	DSSGMKGSPAEELRA CCCCCCCCHHHHHHC	18.54	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN451_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN451_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN451_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN451_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.