ZN431_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN431_MOUSE
• UniProt AC: E9QAG8
• Protein Name: Zinc finger protein 431
• Gene Name: Znf431
• Organism: Mus musculus (Mouse).
• Sequence Length: 526
• Subcellular Localization: Nucleus .
• Protein Description: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1..
• Protein Sequence: MVDALTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLNAVGYNWEDSNIEEHCESSRRHGRHERNHTGEKPYEGIQYGEAFVHHSSLQMRKIIHTGEKRYKCNQCDKAYSRHSILQIHKRTHSGEKPYECNQCGKAFTQHSHLKIHMVTHTGEKPYKCDQCGKAFAFHSTLQVHKRTHTGEKPYECNQCSKAFAHHCHLRVHKRIHTGEKPYKCDQCGKAFVGQNDLKRHERVHTGEKPYKCNECGKAFVCNASLRTHKTTHTGVKPYECKQCTKSFASHGQLQKHERIHTGEKPYKCDQCGKAFASHDKFQKHERIHIGEKPYKCKQCTKSFASHDKLQKHERIHTGEKPYECKQCTKSFASHNKLQKHERIHTGEKPYKCDQCNKAFVYESYLQVHKKTHTGEKPYKCNECGKAFARHSHLKVHKITHTGEKPYKCNQCGKALAYHSTLQVHQRTHTGEKPYECEQCGKAFANQSYFQVHKRIHTGEKPYKCDQCGKAFVGSSDLKRHERVHTGRETLQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	Phosphorylation	RVHKRIHTGEKPYKC EEECCCCCCCCCEEC		25159016
239	Phosphorylation	KRHERVHTGEKPYKC HCCCCCCCCCCCEEC		23140645
295	Phosphorylation	QKHERIHTGEKPYKC CCCCCCCCCCCCEEC		25159016
351	Phosphorylation	QKHERIHTGEKPYEC HHHCCCCCCCCCCCC		25777480
379	Phosphorylation	QKHERIHTGEKPYKC HHCCCCCCCCCCCCC		25159016
407	Phosphorylation	QVHKKTHTGEKPYKC HHCCCCCCCCCCEEC		28059163
491	Phosphorylation	QVHKRIHTGEKPYKC EEECEECCCCCCEEC		25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN431_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN431_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN431_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_MOUSE	Hdac1	physical	21177534
HDAC2_MOUSE	Hdac2	physical	21177534

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.