ZN366_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN366_HUMAN
• UniProt AC: Q8N895
• Protein Name: Zinc finger protein 366 {ECO:0000303|PubMed:12234665}
• Gene Name: ZNF366 {ECO:0000303|PubMed:12234665}
• Organism: Homo sapiens (Human).
• Sequence Length: 744
• Subcellular Localization: Nucleus .
• Protein Description: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases..
• Protein Sequence: MQKEMKMIKDEDVHFDLAVKKTPSFPHCLQPVASRGKAPQRHPFPEALRGPFSQFRYEPPPGDLDGFPGVFEGAGSRKRKSMPTKMPYNHPAEEVTLALHSEENKNHGLPNLPLLFPQPPRPKYDSQMIDLCNVGFQFYRSLEHFGGKPVKQEPIKPSAVWPQPTPTPFLPTPYPYYPKVHPGLMFPFFVPSSSPFPFSRHTFLPKQPPEPLLPRKAEPQESEETKQKVERVDVNVQIDDSYYVDVGGSQKRWQCPTCEKSYTSKYNLVTHILGHSGIKPHACTHCGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRHMMQHSEVKPHNCRVCGRGFAYPSELKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSLTHKGVKEHKCGICGREFTLLANMKRHVLIHTNIRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCGKEFNRMHNLMGHMHLHSDSKPFKCLYCPSKFTLKGNLTRHMKVKHGVMERGLHSQGLGRGRIALAQTAGVLRSLEQEEPFDLSQKRRAKVPVFQSDGESAQGSHCHEEEEEDNCYEVEPYSPGLAPQSQQLCTPEDLSTKSEHAPEVLEEACKEEKEDASKGEWEKRSKGDLGAEGGQERDCAGRDECLSLRAFQSTRRGPSFSDYLYFKHRDESLKELLERKMEKQAVLLGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
141	Phosphorylation	VGFQFYRSLEHFGGK HHHHHHHHHHHCCCC	27.08	25072903
266	Phosphorylation	EKSYTSKYNLVTHIL CCHHCCCHHHHHHHH	17.31	-
316	"N6,N6-dimethyllysine"	HKCQVCHKAFTQTSH CCCCCCHHHHHCHHH	39.82	-
316	Methylation	HKCQVCHKAFTQTSH CCCCCCHHHHHCHHH	39.82	-
447	Acetylation	SLTHKGVKEHKCGIC CCCCCCCCCCCCCCC	63.87	30593719
545	Acetylation	CPSKFTLKGNLTRHM CCCCEECCCCHHHHH	42.57	7964323
553	Ubiquitination	GNLTRHMKVKHGVME CCHHHHHHHHCCHHH	41.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN366_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN366_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN366_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN366_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.