ZN304_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN304_HUMAN
• UniProt AC: Q9HCX3
• Protein Name: Zinc finger protein 304 {ECO:0000312|HGNC:HGNC:13505}
• Gene Name: ZNF304 {ECO:0000312|HGNC:HGNC:13505}
• Organism: Homo sapiens (Human).
• Sequence Length: 659
• Subcellular Localization: Nucleus . Associates with chromatin (PubMed:24623306).
• Protein Description: Acts as transcriptional regulator and plays a role in gene silencing. [PubMed: 24623306]
• Protein Sequence: MAAAVLMDRVQSCVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFSFSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDYDGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRKDTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQHKKVHTGARPYECSECGKFFSRNSGLILHQRVHTGEKPYVCSECGKAYSRSSHLVRHQKAHTGERAHECNSFGGPLAASLKLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Ubiquitination	EMCDPLLKDILHLAE CCCHHHHHHHHHHHH	50.86	-
127	Phosphorylation	GLCRRRFSFSANFYQ HCCHHHCCCCCCCHH	19.24	23898821
129	Phosphorylation	CRRRFSFSANFYQHQ CHHHCCCCCCCHHHH	22.54	28348404
209	Phosphorylation	ESFPHSSSLRQHQGD HHCCCCHHHHHCCCC	30.50	25690035
263	Ubiquitination	CGNVFKEKSALINHR CCCCCCCCCCEEECC	41.44	-
271	Sumoylation	SALINHRKIHSGEIS CCEEECCCCCCCHHH	36.90	-
271	Ubiquitination	SALINHRKIHSGEIS CCEEECCCCCCCHHH	36.90	-
271	Sumoylation	SALINHRKIHSGEIS CCEEECCCCCCCHHH	36.90	-
274	Phosphorylation	INHRKIHSGEISHVC EECCCCCCCHHHHHH	41.41	25159151
308	Phosphorylation	HTGKRHYTCSECGKA CCCCCEEEHHHHCCC	11.93	-
314	Ubiquitination	YTCSECGKAFSRKDT EEHHHHCCCCCCCCC	58.90	-
317	Phosphorylation	SECGKAFSRKDTLVQ HHHCCCCCCCCCEEE	43.19	-
319	Sumoylation	CGKAFSRKDTLVQHQ HCCCCCCCCCEEEEC	54.59	-
319	Ubiquitination	CGKAFSRKDTLVQHQ HCCCCCCCCCEEEEC	54.59	-
319	Sumoylation	CGKAFSRKDTLVQHQ HCCCCCCCCCEEEEC	54.59	-
330	Phosphorylation	VQHQRVHTGERSYDC EEECEECCCCCCEEH	37.57	-
334	Phosphorylation	RVHTGERSYDCSECG EECCCCCCEEHHHHH	22.48	-
338	Phosphorylation	GERSYDCSECGKAYS CCCCEEHHHHHCEEC	32.78	-
358	Phosphorylation	VQHQRIHTGERPYKC HCCCCCCCCCCCCCC	38.06	24719451
375	Ubiquitination	CGKAFSRKDTLVQHQ CCCCCCCCCCCEECC	54.59	-
375	Sumoylation	CGKAFSRKDTLVQHQ CCCCCCCCCCCEECC	54.59	-
375	Sumoylation	CGKAFSRKDTLVQHQ CCCCCCCCCCCEECC	54.59	-
386	Phosphorylation	VQHQRFHTGERPYEC EECCCCCCCCCCEEC	37.72	28555341
414	Phosphorylation	IEHWRIHTGARPYEC HHHEEECCCCCCEEE	30.11	28555341
432	Phosphorylation	GKFFSHNSSLIKHRR CCCCCCCCCHHCCCC	22.54	25627689
433	Phosphorylation	KFFSHNSSLIKHRRV CCCCCCCCHHCCCCC	39.16	25159151
442	Phosphorylation	IKHRRVHTGARSYVC HCCCCCCCCCHHEEE	29.67	-
470	Phosphorylation	VQHQIIHTGARPYEC EECEEEECCCCCEEC	23.33	28555341
482	Ubiquitination	YECSECGKAFSRKDT EECCCCCCCCCCCCC	58.90	-
485	Phosphorylation	SECGKAFSRKDTLVQ CCCCCCCCCCCCCEE	43.19	-
487	Sumoylation	CGKAFSRKDTLVQHQ CCCCCCCCCCCEECC	54.59	-
487	Ubiquitination	CGKAFSRKDTLVQHQ CCCCCCCCCCCEECC	54.59	-
498	Phosphorylation	VQHQKIHTGERPYEC EECCEECCCCCCEEC	44.18	28555341
526	Phosphorylation	IVHQRIHTGAKPYEC EEEEEECCCCCCEEC	36.14	21712546
545	Phosphorylation	KCFSHNSSLILHQRV CCCCCCCCEEEEECC	25.42	23186163
554	Phosphorylation	ILHQRVHTGARPYVC EEEECCCCCCCCEEE	29.67	28555341
597	Phosphorylation	SECGKFFSRNSGLIL CCCCCCCCCCCCEEE	33.41	25394399
600	Phosphorylation	GKFFSRNSGLILHQR CCCCCCCCCEEEEEE	33.59	28555341
610	Phosphorylation	ILHQRVHTGEKPYVC EEEEEEECCCCCEEE	44.15	21712546
647	Phosphorylation	ERAHECNSFGGPLAA CCHHHCCCCCCCCHH	36.61	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN304_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN304_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN304_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP28_HUMAN	USP28	physical	24623306

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.