dbPTM

ZN276_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN276_MOUSE
UniProt AC	Q8CE64
Protein Name	Zinc finger protein 276
Gene Name	Znf276
Organism	Mus musculus (Mouse).
Sequence Length	614
Subcellular Localization	Nucleus . Chromosome, centromere, kinetochore .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MKRDRLGRFLSPGIARQRGGSGGGCGSGRTRGRPSRSGGTSADGAAAQLSWGSMTRSCGDTGDDGTDEAGAGRTLAMGHCRLCHGKFSSRSLRSISDRVPGETSERLSPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQRVNVSPAGQRKPCTKVGVQPTTVAEEGACVADLIASSPRCLHGLVGWVHEHAVSCGSLPSLQRTLSSEYCGIIQAVWGCDQGHDFTMDTASSCRALFLDSALAVKWAWGKDLSPRLAQNSESNPTGAASRLCQARETQVGSETKTLPSVDVALLHSHGDSVGPGLGPCTQPHLAPSEAPGQLGETQVPSSTSDDRVKDEFSDLSEGDFLSEDESDKKQTPQSSDESFEPYPEKKVSGKKSEGREAKRPEEPKIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAQDRALPLEAEPPPGPLSPSGTMEGQAVKPEPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	DRLGRFLSPGIARQR CCHHHHCCCCCHHCC	20.54	22006019
33	Methylation	GSGRTRGRPSRSGGT CCCCCCCCCCCCCCC	23.80	58860369
108	Phosphorylation	GETSERLSPGERVFI CCCCCCCCCCCEEEH	36.76	29514104
170	Phosphorylation	AGQRKPCTKVGVQPT CCCCCCCCCCCCCCC	36.97	-
353	Acetylation	STSDDRVKDEFSDLS CCCCHHHHHHHCCCC	53.05	7720419
357	Phosphorylation	DRVKDEFSDLSEGDF HHHHHHHCCCCCCCC	35.28	21743459
360	Phosphorylation	KDEFSDLSEGDFLSE HHHHCCCCCCCCCCC	44.52	21743459
366	Phosphorylation	LSEGDFLSEDESDKK CCCCCCCCCCCCCCC	42.89	21743459
370	Phosphorylation	DFLSEDESDKKQTPQ CCCCCCCCCCCCCCC	68.03	21743459
375	Phosphorylation	DESDKKQTPQSSDES CCCCCCCCCCCCCCC	31.98	28066266
378	Phosphorylation	DKKQTPQSSDESFEP CCCCCCCCCCCCCCC	40.74	28066266
379	Phosphorylation	KKQTPQSSDESFEPY CCCCCCCCCCCCCCC	39.90	28066266
382	Phosphorylation	TPQSSDESFEPYPEK CCCCCCCCCCCCCCC	39.64	28066266
386	Phosphorylation	SDESFEPYPEKKVSG CCCCCCCCCCCCCCC	19.47	28066266
599	Phosphorylation	EPPPGPLSPSGTMEG CCCCCCCCCCCCCCC	21.83	25338131
601	Phosphorylation	PPGPLSPSGTMEGQA CCCCCCCCCCCCCCC	43.45	30635358
603	Phosphorylation	GPLSPSGTMEGQAVK CCCCCCCCCCCCCCC	19.18	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN276_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN276_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN276_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZN276_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN276_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357 AND SER-360, ANDMASS SPECTROMETRY.	17242355 [Abstract]