ZN106_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN106_MOUSE
• UniProt AC: O88466
• Protein Name: Zinc finger protein 106
• Gene Name: Znf106
• Organism: Mus musculus (Mouse).
• Sequence Length: 1888
• Subcellular Localization: Nucleus, nucleolus .; Isoform 3: Cytoplasm.
• Protein Description: May play a role in modulating tissue specificity to insulin (isoform 3)..
• Protein Sequence: MVRERKCILCHIVYGSKKEMDEHMRSMLHHRELENLKGRDISHECRVCRVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKEEEEEEYFDKELVQLIQERKEQSRQDEPPSNSQEVNSDDRQPQWRREDRIPYQDRESYSQPPRHHRGPPQRDWKWEKDGFNSTRKNSFPHSLRNSGGPRGSSVWHKGATRGSSTWFLNHSNSGGGWHSNNGMVDWNYNGTGRNSSWHSEGTGGFPSWHMNNSNGNWKSSVRGTNSWNYNGLGDKFQQGRNRNPNYQMEDMTKMWNKKSNKPSKYSQERCKWQRQDRDKAAKYRSPPEGYASDTFPSEGLLEFNFEQRESQTTKQTDTAASKINGKNGTKARDKFRRWTPYPSQKTLDLQSALKEVIGSKSDTLEKPLFNFSLITAGLRKPVDKTSNPPVIKTQKAGPPGSPSHKAISDGTAFCEVARACSITEQSEPHQKSNKIPLLKSPLLPLPTPKSGPHKQNLKNRSKNKETKSFPSGDHSHLLNTSTLEGSHGSSYTSKSLGLCPRVLKENKTVSGTQKEPDEKLNNTSQKAQDTVLQCPKTLQNPLPTTPKRMENDAKESSVEESAKDSLSIESQPHSAGNSAMTSDAENHGIKSEGVASLTTEVVSCSTHTVDKEQGSQIPGTPENLSTSPRNSTVLQKEAEVQVSAATSPHSGLLLDLKTSLEDAQDNNLVKSDGPFETESFEDTSLDTELQKPDLNNQPPGTLLPELSKLGFPASLQRDLSRHISLKSKTGTHLPEPNLNSARRIRNVSGHRKNETEKESGLKPTLRQILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEVLDLDEEPDLSSLEGFQWEGVSIPSSSGLARKRSLSESSVVMDRAPVYSFFTGEGTGKENEAQQSPSPNTALSAAQSQKTAMYLEQEVAPLTPSVGTGERVGNIPTQRRHSAQLPSGHIMPVMHSARDLHSQERSTPLSERHAQESTGEGNSLSSNASSGHAVSSLADAATDSSCTSGAEQTDGHSIRKKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLTISLREEELSKSLQCMDNKLLQARAALQTAYVEVQRLLVLKQQITVEMSALRTHRIQILQGLQETYEPPEHPDQAPCSLISREQRNSRSQTSFETALLPAPFFPGFLDPPPSHASLPSPGNPLQITMSTFQAHGTAPDSSVQIKQEPMSPEQEGNMNALPQGCASNVSKELLQTNRVVDDGSSVYPAIPAVIASESTENCQEVSKDLNFSVEQGNSRSKGNSPSCQSPDLPGINRGEETAKGSSGSEACSSSFLRLSFTPETPAEKETQSPADQPEQQAESTLASAETRGSKKKKKLRKKKTLRATHVPENSDTEQDVFTAKPARKVKTAKAAKGAKVTTSQTGQEQGTARDEPDSDSSLEVLEVTNPQLEVVAIDTSESGDEKPDSPSKKDAWIAAEQNPIETSRSGCDEVSSTSELGTRYKDGVPVSVAETQTVISIKASKHSSEISSEPGDDEEPTEGSFEGHQAAVNAIQIFGNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHTSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQLEDRVLCLHNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSVIYTGCYDGSIQAVRLNLMQNYRCWWYGCTLIFGVVDHLKQHLLTDHTNPNFQTLKCRWRNCDAFFTARKGSKQDVAGHIERHAEDDSKIDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	TEVGLSAYAKHISGQ EEEHHHHHHHHHCCC		26026062
139	Phosphorylation	PYQDRESYSQPPRHH CCCCCCCCCCCCCCC		28494245
140	Phosphorylation	YQDRESYSQPPRHHR CCCCCCCCCCCCCCC		28494245
168	Phosphorylation	FNSTRKNSFPHSLRN CCCCCCCCCCHHHCC		27600695
313	Phosphorylation	DRDKAAKYRSPPEGY CHHHHHHHCCCCCCC		26643407
315	Phosphorylation	DKAAKYRSPPEGYAS HHHHHHCCCCCCCCC		26643407
320	Phosphorylation	YRSPPEGYASDTFPS HCCCCCCCCCCCCCC		26643407
322	Phosphorylation	SPPEGYASDTFPSEG CCCCCCCCCCCCCCC		26643407
340	Phosphorylation	FNFEQRESQTTKQTD EECCCCCCCCCCCCH		27149854
342	Phosphorylation	FEQRESQTTKQTDTA CCCCCCCCCCCCHHH		27149854
343	Phosphorylation	EQRESQTTKQTDTAA CCCCCCCCCCCHHHH		27149854
346	Phosphorylation	ESQTTKQTDTAASKI CCCCCCCCHHHHHHH		27149854
348	Phosphorylation	QTTKQTDTAASKING CCCCCCHHHHHHHCC		27149854
351	Phosphorylation	KQTDTAASKINGKNG CCCHHHHHHHCCCCC		27149854
352	Acetylation	QTDTAASKINGKNGT CCHHHHHHHCCCCCC		7712637
384	Ubiquitination	LDLQSALKEVIGSKS HCHHHHHHHHHCCCC		22790023
431	Phosphorylation	QKAGPPGSPSHKAIS CCCCCCCCCCCCCCC		26824392
433	Phosphorylation	AGPPGSPSHKAISDG CCCCCCCCCCCCCCC		25521595
462	Phosphorylation	QSEPHQKSNKIPLLK CCCCCCCCCCCCCCC		-
470	Phosphorylation	NKIPLLKSPLLPLPT CCCCCCCCCCCCCCC		25159016
477	Phosphorylation	SPLLPLPTPKSGPHK CCCCCCCCCCCCCCH		23984901
491	Phosphorylation	KQNLKNRSKNKETKS HHCCCCCCCCCCCCC		29109428
556	Ubiquitination	KLNNTSQKAQDTVLQ HHCCCCHHHHHHHHH		-
574	Phosphorylation	TLQNPLPTTPKRMEN HCCCCCCCCCHHCCC		25159016
575	Phosphorylation	LQNPLPTTPKRMEND CCCCCCCCCHHCCCC		25159016
650	Phosphorylation	QGSQIPGTPENLSTS HCCCCCCCCCCCCCC		29233185
655	Phosphorylation	PGTPENLSTSPRNST CCCCCCCCCCCCCCC		29233185
656	Phosphorylation	GTPENLSTSPRNSTV CCCCCCCCCCCCCCC		21149613
657	Phosphorylation	TPENLSTSPRNSTVL CCCCCCCCCCCCCCC		21149613
673	Phosphorylation	KEAEVQVSAATSPHS EEEEEEEEECCCCCC		26745281
676	Phosphorylation	EVQVSAATSPHSGLL EEEEEECCCCCCCCE		26745281
677	Phosphorylation	VQVSAATSPHSGLLL EEEEECCCCCCCCEE		29895711
737	Phosphorylation	GTLLPELSKLGFPAS CCCHHHHHHCCCCHH		23737553
802	Phosphorylation	LRQILNASRRNVNWE HHHHHHHHHCCCCHH		-
876	Phosphorylation	SGLARKRSLSESSVV CCCCCCCCCCCCCEE		23527152
878	Phosphorylation	LARKRSLSESSVVMD CCCCCCCCCCCEEEE		23527152
880	Phosphorylation	RKRSLSESSVVMDRA CCCCCCCCCEEEECC		25619855
881	Phosphorylation	KRSLSESSVVMDRAP CCCCCCCCEEEECCC		25521595
890	Phosphorylation	VMDRAPVYSFFTGEG EEECCCEEEEECCCC		26239621
891	Phosphorylation	MDRAPVYSFFTGEGT EECCCEEEEECCCCC		26239621
907	Phosphorylation	KENEAQQSPSPNTAL CCCCCCCCCCCHHHH		25266776
909	Phosphorylation	NEAQQSPSPNTALSA CCCCCCCCCHHHHHH		25266776
912	Phosphorylation	QQSPSPNTALSAAQS CCCCCCHHHHHHHHH		28066266
915	Phosphorylation	PSPNTALSAAQSQKT CCCHHHHHHHHHHHH		28066266
934	Phosphorylation	EQEVAPLTPSVGTGE HCCCCCCCCCCCCCC		29514104
953	Phosphorylation	IPTQRRHSAQLPSGH CCCCCCCCCCCCCCC		21082442
958	Phosphorylation	RHSAQLPSGHIMPVM CCCCCCCCCCCHHHC		26745281
973	Phosphorylation	HSARDLHSQERSTPL EEHHHHHHCCCCCCH		27717184
977	Phosphorylation	DLHSQERSTPLSERH HHHHCCCCCCHHHHH		26643407
978	Phosphorylation	LHSQERSTPLSERHA HHHCCCCCCHHHHHH		25266776
1036	Phosphorylation	IRKKRRATGDGSSPE CCCCCCCCCCCCCCC		25619855
1040	Phosphorylation	RRATGDGSSPELPSL CCCCCCCCCCCCHHH		26824392
1041	Phosphorylation	RATGDGSSPELPSLE CCCCCCCCCCCHHHH		26824392
1046	Phosphorylation	GSSPELPSLERKNKR CCCCCCHHHHHHHHH		25619855
1050	Acetylation	ELPSLERKNKRRKIK CCHHHHHHHHHHHCC		2381919
1052	Acetylation	PSLERKNKRRKIKGK HHHHHHHHHHHCCCC		2415003
1218	Phosphorylation	QIKQEPMSPEQEGNM EEEECCCCHHHCCCC		25159016
1279	Phosphorylation	VSKDLNFSVEQGNSR HHHHCCCEECCCCCC		23984901
1285	Phosphorylation	FSVEQGNSRSKGNSP CEECCCCCCCCCCCC		26745281
1287	Phosphorylation	VEQGNSRSKGNSPSC ECCCCCCCCCCCCCC		25619855
1291	Phosphorylation	NSRSKGNSPSCQSPD CCCCCCCCCCCCCCC		21082442
1293	Phosphorylation	RSKGNSPSCQSPDLP CCCCCCCCCCCCCCC		25521595
1296	Phosphorylation	GNSPSCQSPDLPGIN CCCCCCCCCCCCCCC		25521595
1312	Phosphorylation	GEETAKGSSGSEACS CCCCCCCCCCCHHHC		26745281
1313	Phosphorylation	EETAKGSSGSEACSS CCCCCCCCCCHHHCC		26745281
1315	Phosphorylation	TAKGSSGSEACSSSF CCCCCCCCHHHCCCE		28066266
1321	Phosphorylation	GSEACSSSFLRLSFT CCHHHCCCEEEEEEC		22006019
1326	Phosphorylation	SSSFLRLSFTPETPA CCCEEEEEECCCCCC		28833060
1328	Phosphorylation	SFLRLSFTPETPAEK CEEEEEECCCCCCCC		26824392
1331	Phosphorylation	RLSFTPETPAEKETQ EEEECCCCCCCCCCC		28833060
1337	Phosphorylation	ETPAEKETQSPADQP CCCCCCCCCCCCCCH		27180971
1339	Phosphorylation	PAEKETQSPADQPEQ CCCCCCCCCCCCHHH		25521595
1371	Phosphorylation	KKLRKKKTLRATHVP HHHHHCCCEECCCCC		26643407
1375	Phosphorylation	KKKTLRATHVPENSD HCCCEECCCCCCCCC		25619855
1381	Phosphorylation	ATHVPENSDTEQDVF CCCCCCCCCCCHHCC		27087446
1383	Phosphorylation	HVPENSDTEQDVFTA CCCCCCCCCHHCCCC		27087446
1389	Phosphorylation	DTEQDVFTAKPARKV CCCHHCCCCCCCCCC		25619855
1473	Phosphorylation	AEQNPIETSRSGCDE HCCCCCCCCCCCCCC		-
1474	Phosphorylation	EQNPIETSRSGCDEV CCCCCCCCCCCCCCC		-
1476	Phosphorylation	NPIETSRSGCDEVSS CCCCCCCCCCCCCCC		28973931
1502	Phosphorylation	VPVSVAETQTVISIK CEEEEEEEEEEEEEE		27180971
1504	Phosphorylation	VSVAETQTVISIKAS EEEEEEEEEEEEECC		27180971
1507	Phosphorylation	AETQTVISIKASKHS EEEEEEEEEECCCCH		27180971
1688	Phosphorylation	GSYDCTISVRDARNG EEEECEEEEHHHCCC		21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN106_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN106_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN106_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_MOUSE	Grb2	physical	9507006
FYN_MOUSE	Fyn	physical	9507006

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.