ZMY11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZMY11_MOUSE
• UniProt AC: Q8R5C8
• Protein Name: Zinc finger MYND domain-containing protein 11
• Gene Name: Zmynd11
• Organism: Mus musculus (Mouse).
• Sequence Length: 602
• Subcellular Localization: Nucleus . Chromosome . Associates with chromatin and mitotic chromosomes.
• Protein Description: Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. [PubMed: 24590075 Binds non-specifically to dsDNA (By similarity Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth]
• Protein Sequence: MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETETHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKHSNKQEMGTYLRFIVSRMKERAIDLNKKGKDSKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNVHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIERVSVSTQTKKLSASSPRMLHRSTQTTSDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVASLQGDMDRKGKQLKEKCKEEFVEEIKKLAAQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	TYLRFIVSRMKERAI HHHHHHHHHHHHHCH	61.11	23737553
183	Phosphorylation	LNKKGKDSKHPMYRR CCCCCCCCCCHHHHH	2.80	-
377	Phosphorylation	RGEEEAESSISSTSN CCHHHHHHHHCCCCC	17.57	26643407
378	Phosphorylation	GEEEAESSISSTSNE CHHHHHHHHCCCCCH	4.67	26643407
380	Phosphorylation	EEAESSISSTSNEQL HHHHHHHCCCCCHHC	29.46	26643407
381	Phosphorylation	EAESSISSTSNEQLK HHHHHHCCCCCHHCE	25.07	26643407
382	Phosphorylation	AESSISSTSNEQLKV HHHHHCCCCCHHCEE	55.37	26643407
383	Phosphorylation	ESSISSTSNEQLKVT HHHHCCCCCHHCEEC	53.54	26643407
403	Phosphorylation	KKGRRNQSVEPKKEE HCCCCCCCCCCCCCC	5.72	27149854
415	Phosphorylation	KEEPEPETEAVSSSQ CCCCCCCCCCCCCCC	29.86	30635358
419	Phosphorylation	EPETEAVSSSQEIPT CCCCCCCCCCCCCCC	35.44	30635358
420	Phosphorylation	PETEAVSSSQEIPTM CCCCCCCCCCCCCCC	51.99	30635358
421	Phosphorylation	ETEAVSSSQEIPTMP CCCCCCCCCCCCCCC	23.13	30635358
426	Phosphorylation	SSSQEIPTMPQPIER CCCCCCCCCCCCCEE	0.69	30635358
444	Phosphorylation	STQTKKLSASSPRML CCCCCCCCCCCCCCC	35.29	26745281
446	Phosphorylation	QTKKLSASSPRMLHR CCCCCCCCCCCCCCC	37.86	26745281
447	Phosphorylation	TKKLSASSPRMLHRS CCCCCCCCCCCCCCC	57.85	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZMY11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZMY11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZMY11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZMY11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.