ZKSC2_HUMAN - dbPTM
ZKSC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZKSC2_HUMAN
UniProt AC Q63HK3
Protein Name Zinc finger protein with KRAB and SCAN domains 2
Gene Name ZKSCAN2
Organism Homo sapiens (Human).
Sequence Length 967
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MAVALDSQIDAPLEVEGCLIMKVEKDPEWASEPILEGSDSSETFRKCFRQFCYEDVTGPHEAFSKLWELCCRWLKPEMRSKEQILELLVIEQFLTILPEKIQAWAQKQCPQSGEEAVALVVHLEKETGRLRQQVSSPVHREKHSPLGAAWEVADFQPEQVETQPRAVSREEPGSLHSGHQEQLNRKRERRPLPKNARPSPWVPALADEWNTLDQEVTTTRLPAGSQEPVKDVHVARGFSYRKSVHQIPAQRDLYRDFRKENVGNVVSLGSAVSTSNKITRLEQRKEPWTLGLHSSNKRSILRSNYVKEKSVHAIQVPARSAGKTWREQQQWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFEDMDALLNPAARAPSTDKPKEMIPVPRLKRIAISAKEHISLVEEEEAAEDSDDDEIGIEFIRKSEIHGAPVLFQNLSGVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRECGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALINSRASAPSPSTPEEVPSPSRQERGGIEVEPQEPTGWEPEETSQEAVIEDSCSERMSEEEIVQEPEFQGPPGLLQSPNDFEIGSSIKEDPTQIVYKDMEQHRALIEKSKRVVSQSTDPSKYRKRECISGRQWENLQGIRQGKPMSQPRDLGKAVVHQRPFVGKRPYRLLKYGESFGRSTRLMCRMTHHKENPYKCGVCGKCFGRSRSLIRHQRIHTGEKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKPYQCGECGKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHREVHVREKPLPHPPSLYCPENPHKGKTDEFRKTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22SumoylationVEGCLIMKVEKDPEW
EECEEEEEEECCCHH		40.0028112733
31PhosphorylationEKDPEWASEPILEGS
ECCCHHHCCCCCCCC		45.00-
38PhosphorylationSEPILEGSDSSETFR
CCCCCCCCCCHHHHH		25.58-
40PhosphorylationPILEGSDSSETFRKC
CCCCCCCCHHHHHHH		31.60-
43PhosphorylationEGSDSSETFRKCFRQ
CCCCCHHHHHHHHHH		30.59-
135PhosphorylationGRLRQQVSSPVHREK
CCHHHHCCCCCHHCC		25.2922210691
136PhosphorylationRLRQQVSSPVHREKH
CHHHHCCCCCHHCCC		31.8928985074
144PhosphorylationPVHREKHSPLGAAWE
CCHHCCCCCCCHHHH		32.6525159151
242SumoylationARGFSYRKSVHQIPA
ECCCCCCCCHHHCCC		48.9028112733
242SumoylationARGFSYRKSVHQIPA
ECCCCCCCCHHHCCC		48.90-
259SumoylationDLYRDFRKENVGNVV
HHHHHHHHHCCCCEE		54.3428112733
277SumoylationSAVSTSNKITRLEQR
HHHCCCCCCCHHHHC		45.2628112733
289PhosphorylationEQRKEPWTLGLHSSN
HHCCCCCCCCCCCCC		22.97-
297UbiquitinationLGLHSSNKRSILRSN
CCCCCCCCHHHHHHC		49.85-
337SumoylationQWGLEDEKIAGVHWS
HHCCCCCCCCCCCCC		50.6128112733
371O-linked_GlycosylationLQACPRNSQVYGAVA
HHHCCCCCHHHHHHH		23.4630379171
434PhosphorylationNPAARAPSTDKPKEM
CHHHCCCCCCCCHHH		48.53-
435PhosphorylationPAARAPSTDKPKEMI
HHHCCCCCCCCHHHC		47.16-
482SumoylationIGIEFIRKSEIHGAP
CHHHHHHHHHCCCCC		47.8528112733
529SumoylationQACHRKSKLYGAVAE
HHHHHHCHHHHHHHH		49.0828112733
529SumoylationQACHRKSKLYGAVAE
HHHHHHCHHHHHHHH		49.08-
531PhosphorylationCHRKSKLYGAVAEQL
HHHHCHHHHHHHHHH		13.53-
585PhosphorylationEMDALINSRASAPSP
HHHHHHHCCCCCCCC		23.41-
588PhosphorylationALINSRASAPSPSTP
HHHHCCCCCCCCCCC		39.3325850435
591PhosphorylationNSRASAPSPSTPEEV
HCCCCCCCCCCCCCC		31.0621712546
593PhosphorylationRASAPSPSTPEEVPS
CCCCCCCCCCCCCCC		62.0129255136
594PhosphorylationASAPSPSTPEEVPSP
CCCCCCCCCCCCCCC		37.8029255136
600PhosphorylationSTPEEVPSPSRQERG
CCCCCCCCCCCCCCC		40.4630266825
602PhosphorylationPEEVPSPSRQERGGI
CCCCCCCCCCCCCCE		51.4330266825
658PhosphorylationGPPGLLQSPNDFEIG
CCCCCCCCCCCCCCC		26.16-
724SumoylationLQGIRQGKPMSQPRD
HCCHHCCCCCCCCCC		29.25-
724SumoylationLQGIRQGKPMSQPRD
HCCHHCCCCCCCCCC		29.25-
727PhosphorylationIRQGKPMSQPRDLGK
HHCCCCCCCCCCCCC		45.63-
734SumoylationSQPRDLGKAVVHQRP
CCCCCCCCCCHHCCC		45.3528112733
745SumoylationHQRPFVGKRPYRLLK
HCCCCCCCCCEEEHH		44.9228112733
752SumoylationKRPYRLLKYGESFGR
CCCEEEHHCHHHCCH		56.6628112733
753PhosphorylationRPYRLLKYGESFGRS
CCEEEHHCHHHCCHH		26.54-
761PhosphorylationGESFGRSTRLMCRMT
HHHCCHHHHHHHHHH		26.85-
787PhosphorylationCGKCFGRSRSLIRHQ
CHHHHCCCHHHHHCC		26.9723532336
789PhosphorylationKCFGRSRSLIRHQRI
HHHCCCHHHHHCCCC		29.4223532336
798PhosphorylationIRHQRIHTGEKPFKC
HHCCCCCCCCCCEEE		44.6718669648
815PhosphorylationCGKSFNDSSNFGAHQ
CCCCCCCCCCCCCCC		28.4328555341
816PhosphorylationGKSFNDSSNFGAHQR
CCCCCCCCCCCCCCC		38.7628985074
826PhosphorylationGAHQRIHTGEKPYRC
CCCCCCCCCCCCEEC		44.6729496963
829SumoylationQRIHTGEKPYRCGEC
CCCCCCCCCEECCCC		49.01-
829SumoylationQRIHTGEKPYRCGEC
CCCCCCCCCEECCCC		49.01-
829UbiquitinationQRIHTGEKPYRCGEC
CCCCCCCCCEECCCC		49.01-
843PhosphorylationCGKCFSQSSSLIIHQ
CHHHCCCCCCEEEEE		22.2423186163
844PhosphorylationGKCFSQSSSLIIHQR
HHHCCCCCCEEEEEC		22.8723186163
845PhosphorylationKCFSQSSSLIIHQRT
HHCCCCCCEEEEECC		28.9125106551
852PhosphorylationSLIIHQRTHTGEKPY
CEEEEECCCCCCCCE		19.74-
854PhosphorylationIIHQRTHTGEKPYQC
EEEECCCCCCCCEEC		46.56-
857AcetylationQRTHTGEKPYQCGEC
ECCCCCCCCEECCCC		50.827428793
894UbiquitinationYKCVDCEKSFNNCTR
CCEECCHHHCCCCCH		67.68-
910PhosphorylationREHRRIHTGEKPYGC
HHHCCCCCCCCCCCC		44.6728111955
925PhosphorylationAQCGKRFSKSSVLTK
CCCCCCCCCHHHHHC		35.3429396449
927PhosphorylationCGKRFSKSSVLTKHR
CCCCCCCHHHHHCCC		25.2029396449
928PhosphorylationGKRFSKSSVLTKHRE
CCCCCCHHHHHCCCE		25.5329396449
931PhosphorylationFSKSSVLTKHREVHV
CCCHHHHHCCCEEEC		23.7329396449
966PhosphorylationKTDEFRKTF------
CCHHHHHCC------		30.2627134283
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZKSC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZKSC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZKSC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZKSC2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZKSC2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-591; THR-594 ANDSER-600, AND MASS SPECTROMETRY.

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