ZIC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZIC5_HUMAN
• UniProt AC: Q96T25
• Protein Name: Zinc finger protein ZIC 5
• Gene Name: ZIC5
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Nucleus.
• Protein Description: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity)..
• Protein Sequence: MFLKAGRGNKVPPVRVYGPDCVVLMEPPLSKRNPPALRLADLATAQVQPLQNMTGFPALAGPPAHSQLRAAVAHLRLRDLGADPGVATTPLGPEHMAQASTLGLSPPSQAFPAHPEAPAAAARAAALVAHPGAGSYPCGGGSSGAQPSAPPPPAPPLPPTPSPPPPPPPPPPPALSGYTTTNSGGGGSSGKGHSRDFVLRRDLSATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGMFISASGTYAGPDGSGGPALFPALHDTPGAPGGHPHPLNGQMRLGLAAAAAAAAAELYGRAEPPFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAGPGPHLQHHAPPPAPPPPPAPAQHPHQHHPHLPGAAGAFLRYMRQPIKQELICKWIDPDELAGLPPPPPPPPPPPPPPPAGGAKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGPLGYSSVGTPVGAPLSPVLDPARSHSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSETEDEEIYGNPEVVRTIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	Dimethylation	APLGGEQRSGTGSPQ CCCCCCCCCCCCCCC	32.52	-
222	Methylation	APLGGEQRSGTGSPQ CCCCCCCCCCCCCCC	32.52	115390843
297	Phosphorylation	AAAAAELYGRAEPPF HHHHHHHHCCCCCCC	8.96	26437602
486	Phosphorylation	INHIRVHTGEKPFPC CEEEEEECCCCCCCC	44.15	-
500	Acetylation	CPFPGCGKVFARSEN CCCCCCCCEEEECCC	37.95	-
514	Phosphorylation	NLKIHKRTHTGEKPF CEEEECCCCCCCCCE	28.70	23312004
516	Phosphorylation	KIHKRTHTGEKPFKC EEECCCCCCCCCEEC	46.56	29496963
554	Phosphorylation	SDKPYYCKIRGCDKS CCCCEEEEECCCCCC	21.22	18669648
558	Phosphorylation	YYCKIRGCDKSYTHP EEEEECCCCCCCCCH	4.23	18669648
566	Phosphorylation	DKSYTHPSSLRKHMK CCCCCCHHHHHHHCE	34.11	27080861
567	Phosphorylation	KSYTHPSSLRKHMKI CCCCCHHHHHHHCEE	36.32	27080861
576	Phosphorylation	RKHMKIHCKSPPPSP HHHCEEEECCCCCCC	5.48	18669648
578	Phosphorylation	HMKIHCKSPPPSPGP HCEEEECCCCCCCCC	48.29	25022875
582	Phosphorylation	HCKSPPPSPGPLGYS EECCCCCCCCCCCCC	48.54	21712546
588	Phosphorylation	PSPGPLGYSSVGTPV CCCCCCCCCCCCCCC	12.88	20363803
589	Phosphorylation	SPGPLGYSSVGTPVG CCCCCCCCCCCCCCC	19.42	20873877
590	Phosphorylation	PGPLGYSSVGTPVGA CCCCCCCCCCCCCCC	18.97	20873877
593	Phosphorylation	LGYSSVGTPVGAPLS CCCCCCCCCCCCCCC	16.79	20873877
600	Phosphorylation	TPVGAPLSPVLDPAR CCCCCCCCCCCCHHH	16.35	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZIC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZIC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZIC5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZIC5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578 AND SER-600, ANDMASS SPECTROMETRY.
PubMed: 18669648