ZFHX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFHX2_HUMAN
• UniProt AC: Q9C0A1
• Protein Name: Zinc finger homeobox protein 2
• Gene Name: ZFHX2
• Organism: Homo sapiens (Human).
• Sequence Length: 2572
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGGEAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQGFSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEAQLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQRRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTLAGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTLPRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPALLGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNALLQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	NSASTTGTTPSPGHN CCCCCCCCCCCCCCC	33.18	-
13	Phosphorylation	SASTTGTTPSPGHNA CCCCCCCCCCCCCCC	24.10	-
38	Phosphorylation	STPSDPVTKDPPAAS CCCCCCCCCCCCCCC	34.81	-
408	Phosphorylation	TLPAPVGSPEDPSDP CCCCCCCCCCCCCCC	25.91	27732954
413	Phosphorylation	VGSPEDPSDPPQPYR CCCCCCCCCCCCCCC	75.07	-
500	Phosphorylation	PRLARGESYNCGYKP CCCCCCCCCCCCCCC	25.19	-
501	Phosphorylation	RLARGESYNCGYKPY CCCCCCCCCCCCCCE	15.35	-
524	Phosphorylation	TTTKGNLSIHMQSDK CCCCCCEEEEECCCH	17.91	28555341
686	Phosphorylation	TSAPGSLSPDAHLPP CCCCCCCCCCCCCCH	23.56	25921289
707	Phosphorylation	SSDSLPTSPPPDDSL CCCCCCCCCCCCCCH	33.21	25921289
713	Phosphorylation	TSPPPDDSLSLKVFR CCCCCCCCHHHHHHH	27.51	24719451
715	Phosphorylation	PPPDDSLSLKVFRCL CCCCCCHHHHHHHHH	30.05	24719451
757	Phosphorylation	WKEVAGDTHRCKLCC HHHHCCCCEEEEEEE	15.42	-
786	Phosphorylation	TDKHAQKYQLAAHLR CCHHHHHHHHHHHHH	9.18	22210691
815	Phosphorylation	GDGAPYGSVSPLHLR CCCCCCCCCCCCEEE	17.36	25332170
939	Phosphorylation	TPGKAPVTPLAEPPT CCCCCCCCCCCCCCC	16.13	30266825
946	Phosphorylation	TPLAEPPTPEKDAQN CCCCCCCCCCHHHCC	55.59	30266825
960	Phosphorylation	NKTEQLASEETENKT CHHHHHHHHHHCCCC	44.55	30631047
1064	Phosphorylation	VLSAPTLSPLDNGQE HHCCCCCCCCCCCCC	26.37	-
1227	Phosphorylation	KKAAIDPSAPARGEA HHHHCCCCCCCCCCC	43.04	22210691
1291	Phosphorylation	KIEGPERSQEEPKEG CCCCCCCCCCCCCCC	40.04	21406692
1313	Phosphorylation	TEKKGPDTSGFISGL CCCCCCCCCCCCCCC	33.60	-
1314	Phosphorylation	EKKGPDTSGFISGLP CCCCCCCCCCCCCCC	38.80	-
1354	Phosphorylation	PFPLVPESLLKLQQQ CCCCCCHHHHHHHHH	32.69	24719451
1425	Phosphorylation	EGNEAGPSSPPDPLP CCCCCCCCCCCCCCC	55.34	30266825
1426	Phosphorylation	GNEAGPSSPPDPLPN CCCCCCCCCCCCCCC	43.52	30266825
1490	O-linked_Glycosylation	GACGKLFSNMLILKT CHHHHHHHCCEEHHC	31.59	30379171
1659	Phosphorylation	KNACEGGSMPTGGGT HCCCCCCCCCCCCCC	32.23	-
1662	Phosphorylation	CEGGSMPTGGGTGGA CCCCCCCCCCCCCCC	39.56	-
1670	Phosphorylation	GGGTGGASGCRRCHA CCCCCCCCCCCHHHH	41.52	-
1673	Methylation	TGGASGCRRCHATFS CCCCCCCCHHHHHHH	48.03	115388507
1822	Phosphorylation	RNPLVAATSPMPGPP CCCEEEECCCCCCCC	24.51	24719451
1880	Phosphorylation	YRWYMQDSNPTRKML HHHHHCCCCCCHHHH	28.02	24275569
1897	Acetylation	ISEEVGLKKRVVQVW HHHHHCCCHHHHHHH	32.38	7492107
2070	Phosphorylation	MGQRRYRTQMSSLQL CCCHHHHHHHHHHHH	21.49	29978859
2073	Phosphorylation	RRYRTQMSSLQLKIM HHHHHHHHHHHHHHH	20.34	29978859
2074	Phosphorylation	RYRTQMSSLQLKIMK HHHHHHHHHHHHHHH	18.13	29978859
2128	Phosphorylation	KKAKLQGTAAGSTGG HHHHHCCCCCCCCCC	10.60	24850871
2133	Phosphorylation	QGTAAGSTGGSSEGL CCCCCCCCCCCHHHH	44.65	24850871
2467	Phosphorylation	FDGEAPATAHQRSFC CCCCCCCCCCCCCEE	24.50	-
2472	Phosphorylation	PATAHQRSFCFFGRG CCCCCCCCEEEECCC	21.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFHX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFHX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFHX2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZFHX2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.