ZFAN6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFAN6_MOUSE
• UniProt AC: Q9DCH6
• Protein Name: AN1-type zinc finger protein 6
• Gene Name: Zfand6
• Organism: Mus musculus (Mouse).
• Sequence Length: 223
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes..
• Protein Sequence: MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSSNGRISPPAASVSSLSESLPVQCADGSVPDAQSALDSTSSSMQPGPVSNQSLLSESVAPSQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQKKNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGEKIQKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAQETNHSQAPM ---CCCCCCCCCCCE	26.59	25619855
8	Phosphorylation	MAQETNHSQAPMLCS CCCCCCCCCCCEEEC	30.06	25619855
15	Phosphorylation	SQAPMLCSTGCGFYG CCCCEEECCCCCCCC	24.71	25619855
16	Phosphorylation	QAPMLCSTGCGFYGN CCCEEECCCCCCCCC	35.18	25619855
21	Phosphorylation	CSTGCGFYGNPRTNG ECCCCCCCCCCCCCC	10.98	25619855
43	Phosphorylation	EHLQRQNSSNGRISP HHHHHHCCCCCCCCC	19.49	-
49	Phosphorylation	NSSNGRISPPAASVS CCCCCCCCCCCHHHH	24.38	-
115	Phosphorylation	TSVDKAVSETEDLQG CCHHHHHHCCCCCCC	43.60	26824392
117	Phosphorylation	VDKAVSETEDLQGPR HHHHHHCCCCCCCCC	27.56	25619855
137	Phosphorylation	PLECDPPSSVSDTTQ EEECCCCCCCCCCCC	49.08	25777480
138	Phosphorylation	LECDPPSSVSDTTQQ EECCCCCCCCCCCCC	31.26	25777480
140	Phosphorylation	CDPPSSVSDTTQQPS CCCCCCCCCCCCCCC	31.05	25777480
142	Phosphorylation	PPSSVSDTTQQPSEE CCCCCCCCCCCCCHH	20.99	25777480
143	Phosphorylation	PSSVSDTTQQPSEEQ CCCCCCCCCCCCHHH	30.14	25777480
147	Phosphorylation	SDTTQQPSEEQSKSL CCCCCCCCHHHHHHC	49.80	25777480
151	Phosphorylation	QQPSEEQSKSLEKPK CCCCHHHHHHCCCHH	27.73	25777480
153	Phosphorylation	PSEEQSKSLEKPKQK CCHHHHHHCCCHHHH	47.19	25777480
198	Phosphorylation	SDVHNCSYNYKADAA CCCCCCCCEECHHHH	25.39	29514104
219	Acetylation	NPVVVGEKIQKI--- CCEEEEHHHCCC---	44.50	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFAN6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFAN6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFAN6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKN1_RAT	Pkn1	physical	11054541

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.