dbPTM

ZEB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZEB2_MOUSE
UniProt AC	Q9R0G7
Protein Name	Zinc finger E-box-binding homeobox 2
Gene Name	Zeb2
Organism	Mus musculus (Mouse).
Sequence Length	1215
Subcellular Localization	Nucleus.
Protein Description	Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin..
Protein Sequence	MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKLHIAEDDSLANPLDQDTSPASMPNHESSPHMSQGLLPREEEEEELRESVVEHSWHSGEILQASVAGPEEMKEDYDAMGPEATIQTTINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGSSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHSISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGLTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERTSKPLAPNSNPTTKDSLLPRSPVKPMDSITSPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMREPKGIIATKNKTKATSINLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSNNPVFGMNPFSAKPLYTPLPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGDLLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEEGYGKLRRRDGDEEEEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGME

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	DNVVDAGSETDEEDK CCCCCCCCCCCHHHC	38.76	23684622
38	Phosphorylation	VVDAGSETDEEDKLH CCCCCCCCCHHHCCC	50.86	23684622
70	Phosphorylation	ASMPNHESSPHMSQG CCCCCCCCCCCHHCC	41.43	25338131
141	Phosphorylation	TVKNANCTSDFEEYF CCCCCCCCCCHHHHH	31.01	26643407
142	Phosphorylation	VKNANCTSDFEEYFA CCCCCCCCCHHHHHH	42.37	26643407
162	Phosphorylation	ERDGHAVSIEEYLQR HCCCCEECHHHHHHH	25.68	25521595
166	Phosphorylation	HAVSIEEYLQRSDTA CEECHHHHHHHCCCE	8.71	25159016
184	Phosphorylation	PEAPEELSRLGTPEA CCCHHHHHHCCCCCC	28.83	25619855
188	Phosphorylation	EELSRLGTPEANGQE HHHHHCCCCCCCCCC	23.65	22817900
203	Phosphorylation	ENDLPPGTPDAFAQL CCCCCCCCHHHHHHH	24.62	22817900
224	Phosphorylation	DRGYKRLTSLKEHIK CCCHHHHHHHHHHHH	35.73	29176673
225	Phosphorylation	RGYKRLTSLKEHIKY CCHHHHHHHHHHHHH	41.87	22942356
324	Phosphorylation	KRFSHSGSYSSHISS CCCCCCCCCCCCCCC	25.51	22871156
325	Phosphorylation	RFSHSGSYSSHISSK CCCCCCCCCCCCCCC	20.09	22871156
326	Phosphorylation	FSHSGSYSSHISSKK CCCCCCCCCCCCCCC	19.69	22871156
350	Phosphorylation	RMRNNIKTGSSPNSV EECCCCCCCCCCCCC	38.20	23527152
352	Phosphorylation	RNNIKTGSSPNSVSS CCCCCCCCCCCCCCC	48.10	22942356
353	Phosphorylation	NNIKTGSSPNSVSSS CCCCCCCCCCCCCCC	29.46	25521595
356	Phosphorylation	KTGSSPNSVSSSPTN CCCCCCCCCCCCCCC	27.10	22942356
358	Phosphorylation	GSSPNSVSSSPTNSA CCCCCCCCCCCCCHH	25.56	21082442
359	Phosphorylation	SSPNSVSSSPTNSAI CCCCCCCCCCCCHHH	37.88	22942356
360	Phosphorylation	SPNSVSSSPTNSAIT CCCCCCCCCCCHHHH	28.39	22942356
362	Phosphorylation	NSVSSSPTNSAITQL CCCCCCCCCHHHHHH	43.69	21082442
364	Phosphorylation	VSSSPTNSAITQLRN CCCCCCCHHHHHHHH	24.43	21082442
367	Phosphorylation	SPTNSAITQLRNKLE CCCCHHHHHHHHHHH	22.67	25619855
377	Acetylation	RNKLENGKPLSMSEQ HHHHHCCCCCCHHHH	55.13	22826441
504	Phosphorylation	QPEEQGVTSPNIPPV CCHHCCCCCCCCCCC	45.34	26060331
505	Phosphorylation	PEEQGVTSPNIPPVG CHHCCCCCCCCCCCC	17.34	26060331
637	Phosphorylation	DNKALLLSSVLSEKG CCHHHHHHHHHHHCC	20.54	28066266
638	Phosphorylation	NKALLLSSVLSEKGL CHHHHHHHHHHHCCC	27.35	28066266
641	Phosphorylation	LLLSSVLSEKGLTSP HHHHHHHHHCCCCCC	34.80	28066266
643	Ubiquitination	LSSVLSEKGLTSPIN HHHHHHHCCCCCCCC	56.71	-
646	Phosphorylation	VLSEKGLTSPINPYK HHHHCCCCCCCCCCH	40.92	26745281
647	Phosphorylation	LSEKGLTSPINPYKD HHHCCCCCCCCCCHH	28.91	26824392
652	Phosphorylation	LTSPINPYKDHMSVL CCCCCCCCHHHHHHH	25.26	28725479
698	Phosphorylation	WFEQRKVYQYSNSRS HHHHHCHHHCCCCCC	12.55	26643407
700	Phosphorylation	EQRKVYQYSNSRSPS HHHCHHHCCCCCCCC	7.67	26643407
701	Phosphorylation	QRKVYQYSNSRSPSL HHCHHHCCCCCCCCC	16.89	26745281
703	Phosphorylation	KVYQYSNSRSPSLER CHHHCCCCCCCCCCC	28.35	25168779
705	Phosphorylation	YQYSNSRSPSLERTS HHCCCCCCCCCCCCC	20.75	25168779
707	Phosphorylation	YSNSRSPSLERTSKP CCCCCCCCCCCCCCC	44.07	25168779
711	Phosphorylation	RSPSLERTSKPLAPN CCCCCCCCCCCCCCC	31.56	26643407
712	Phosphorylation	SPSLERTSKPLAPNS CCCCCCCCCCCCCCC	38.20	26643407
719	Phosphorylation	SKPLAPNSNPTTKDS CCCCCCCCCCCCCCC	43.03	25367039
722	Phosphorylation	LAPNSNPTTKDSLLP CCCCCCCCCCCCCCC	51.21	25367039
723	Phosphorylation	APNSNPTTKDSLLPR CCCCCCCCCCCCCCC	33.83	25367039
726	Phosphorylation	SNPTTKDSLLPRSPV CCCCCCCCCCCCCCC	33.10	25159016
731	Phosphorylation	KDSLLPRSPVKPMDS CCCCCCCCCCCCCCC	31.91	26824392
738	Phosphorylation	SPVKPMDSITSPSIA CCCCCCCCCCCCCHH	22.86	25159016
740	Phosphorylation	VKPMDSITSPSIAEL CCCCCCCCCCCHHHH	38.24	25159016
741	Phosphorylation	KPMDSITSPSIAELH CCCCCCCCCCHHHHH	18.25	25159016
743	Phosphorylation	MDSITSPSIAELHNS CCCCCCCCHHHHHHC	33.91	25159016
750	Phosphorylation	SIAELHNSVTSCDPP CHHHHHHCCCCCCCC	18.94	29472430
752	Phosphorylation	AELHNSVTSCDPPLR HHHHHCCCCCCCCCC	24.37	29472430
763	Phosphorylation	PPLRLTKSSHFTNIK CCCCCCCCCCCCCCC	24.66	24719451
778	Phosphorylation	AVDKLDHSRSNTPSP EECCCCCCCCCCCCC	36.75	25338131
780	Phosphorylation	DKLDHSRSNTPSPLN CCCCCCCCCCCCCCC	48.33	21082442
782	Phosphorylation	LDHSRSNTPSPLNLS CCCCCCCCCCCCCCC	26.79	22942356
784	Phosphorylation	HSRSNTPSPLNLSST CCCCCCCCCCCCCCC	39.73	27818261
789	Phosphorylation	TPSPLNLSSTSSKNS CCCCCCCCCCCCCCC	30.42	25619855
790	Phosphorylation	PSPLNLSSTSSKNSH CCCCCCCCCCCCCCC	35.16	25619855
791	Phosphorylation	SPLNLSSTSSKNSHS CCCCCCCCCCCCCCC	33.37	25619855
792	Phosphorylation	PLNLSSTSSKNSHSS CCCCCCCCCCCCCCC	41.06	25619855
793	Phosphorylation	LNLSSTSSKNSHSSS CCCCCCCCCCCCCCC	35.62	25619855
796	Phosphorylation	SSTSSKNSHSSSYTP CCCCCCCCCCCCCCC	28.60	26643407
798	Phosphorylation	TSSKNSHSSSYTPNS CCCCCCCCCCCCCCC	22.32	26643407
799	Phosphorylation	SSKNSHSSSYTPNSF CCCCCCCCCCCCCCC	23.18	29550500
800	Phosphorylation	SKNSHSSSYTPNSFS CCCCCCCCCCCCCCC	35.72	26643407
801	Phosphorylation	KNSHSSSYTPNSFSS CCCCCCCCCCCCCCC	28.32	26643407
802	Phosphorylation	NSHSSSYTPNSFSSE CCCCCCCCCCCCCCH	20.24	26643407
805	Phosphorylation	SSSYTPNSFSSEELQ CCCCCCCCCCCHHHH	27.92	26643407
807	Phosphorylation	SYTPNSFSSEELQAE CCCCCCCCCHHHHCC	36.34	26643407
808	Phosphorylation	YTPNSFSSEELQAEP CCCCCCCCHHHHCCC	32.83	26643407
923	Phosphorylation	SIPGLRPYPGLDQMS CCCCCCCCCCCCHHC	11.96	-
930	Phosphorylation	YPGLDQMSFLPHMAY CCCCCHHCCCCCCCC	20.28	20531401
945	Phosphorylation	TYPTGAATFADMQQR CCCCCCCHHHHHHHH	20.87	20531401
974	Phosphorylation	DGAQDYMSGLDDMTD HHHHHHHHCCCCCCC	29.94	26643407
980	Phosphorylation	MSGLDDMTDSDSCLS HHCCCCCCCCCCHHH	39.07	26643407
982	Phosphorylation	GLDDMTDSDSCLSRK CCCCCCCCCCHHHHH	23.43	26643407
984	Phosphorylation	DDMTDSDSCLSRKKI CCCCCCCCHHHHHHC	22.40	26643407
987	Phosphorylation	TDSDSCLSRKKIKKT CCCCCHHHHHHCCCC	46.51	26643407
1013	Phosphorylation	KTFQKSSSLLRHKYE HHHHHCHHHHHHHHC	38.21	27149854
1050	Phosphorylation	IEHSRLHSGEKPYQC HHHCCCCCCCCCCCC	53.92	28066266
1055	Phosphorylation	LHSGEKPYQCDKCGK CCCCCCCCCCCCCCC	32.61	28066266
1112	Phosphorylation	ELLMNRAYLQSITPQ HHHHCHHHHHHCCCC	11.31	30635358
1115	Phosphorylation	MNRAYLQSITPQGYS HCHHHHHHCCCCCCC	26.32	25619855
1117	Phosphorylation	RAYLQSITPQGYSDS HHHHHHCCCCCCCCH	18.14	27742792
1121	Phosphorylation	QSITPQGYSDSEERE HHCCCCCCCCHHHHH	12.21	25619855
1122	Phosphorylation	SITPQGYSDSEERES HCCCCCCCCHHHHHC	41.29	25521595
1124	Phosphorylation	TPQGYSDSEERESMP CCCCCCCHHHHHCCC	35.10	27742792
1129	Phosphorylation	SDSEERESMPRDGES CCHHHHHCCCCCCCC	40.06	27742792
1136	Phosphorylation	SMPRDGESEKEHEKE CCCCCCCCHHHHHHC	60.54	25159016
1167	Phosphorylation	EEEEEEESENKSMDT HHHHHHHHHHCCCCC	50.15	25521595
1171	Phosphorylation	EEESENKSMDTDPET HHHHHHCCCCCCHHH	33.21	27180971
1174	Phosphorylation	SENKSMDTDPETIRD HHHCCCCCCHHHHCC	44.82	27180971
1203	Phosphorylation	DGKMETKSDHEEDNM CCCCCCCCCCCHHCH	52.17	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZEB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
391	K	Sumoylation	-
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.
866	K	Sumoylation	-
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZEB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZEB2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZEB2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; THR-38; SER-778;SER-780; THR-782; SER-784 AND SER-1167, AND MASS SPECTROMETRY.	19367708 [Abstract]

show

show