ZDHC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDHC3_HUMAN
• UniProt AC: Q9NYG2
• Protein Name: Palmitoyltransferase ZDHHC3 {ECO:0000305}
• Gene Name: ZDHHC3 {ECO:0000312|HGNC:HGNC:18470}
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Palmitoyltransferase with broad specificity. [PubMed: 21926431]
• Protein Sequence: MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	NIERKPEYLQPEKCV CCCCCCHHCCHHHCC	21.11	28674419
100	Phosphorylation	SHCRAMLTDPGAVPK HHHHHHHCCCCCCCC	27.36	24114839
112	Ubiquitination	VPKGNATKEFIESLQ CCCCCCCHHHHHHCC	48.49	-
121	Acetylation	FIESLQLKPGQVVYK HHHHCCCCCCCEEEE	33.85	19608861
121	Ubiquitination	FIESLQLKPGQVVYK HHHHCCCCCCCEEEE	33.85	-
127	Phosphorylation	LKPGQVVYKCPKCCS CCCCCEEEECCCCCC	14.17	22817900
128 (in isoform 2)	Malonylation	-	32.24	32601280
128	Acetylation	KPGQVVYKCPKCCSI CCCCEEEECCCCCCC	32.24	25953088
146	S-palmitoylation	RAHHCSVCKRCIRKM CHHCCHHHHHHHHHC	1.01	-
231	Phosphorylation	GLLFLIFTSVMFGTQ HHHHHHHHHHHHCCH	39.55	-
232	Phosphorylation	LLFLIFTSVMFGTQV HHHHHHHHHHHCCHH	34.06	-
241	Phosphorylation	MFGTQVHSICTDETG HHCCHHHHHCCCHHH	16.01	-
286	Phosphorylation	GWASPFATPDQGKAD CCCCCCCCCCCCCCC	40.77	25159151
295	Phosphorylation	DQGKADPYQYVV--- CCCCCCCCCCCC---	27.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDHC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDHC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDHC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDHC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.