ZDH14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDH14_HUMAN
• UniProt AC: Q8IZN3
• Protein Name: Probable palmitoyltransferase ZDHHC14
• Gene Name: ZDHHC14
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MPPGGGGPMKDCEYSQISTHSSSPMESPHKKKKIAARRKWEVFPGRNKFFCNGRIMMARQTGVFYLTLVLILVTSGLFFAFDCPYLAVKITPAIPAVAGILFFFVMGTLLRTSFSDPGVLPRATPDEAADLERQIDIANGTSSGGYRPPPRTKEVIINGQTVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQTGFLNALKDSPASVLEAVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQSDMCDQDQCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEAPSPPRLLAAGSPLAHSRTMHVLGLASQDSLHEDSVRGLVKLSSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	GPMKDCEYSQISTHS CCCCCCCCCCCCCCC	16.53	29978859
15	Phosphorylation	PMKDCEYSQISTHSS CCCCCCCCCCCCCCC	9.95	29978859
18	Phosphorylation	DCEYSQISTHSSSPM CCCCCCCCCCCCCCC	16.66	29978859
19	Phosphorylation	CEYSQISTHSSSPME CCCCCCCCCCCCCCC	27.66	29978859
21	Phosphorylation	YSQISTHSSSPMESP CCCCCCCCCCCCCCC	32.38	29978859
22	Phosphorylation	SQISTHSSSPMESPH CCCCCCCCCCCCCCC	30.75	29978859
23	Phosphorylation	QISTHSSSPMESPHK CCCCCCCCCCCCCCH	31.14	29978859
27	Phosphorylation	HSSSPMESPHKKKKI CCCCCCCCCCHHHCH	26.50	29978859
61	Phosphorylation	RIMMARQTGVFYLTL CEEECHHHHHHHHHH	29.74	24043423
65	Phosphorylation	ARQTGVFYLTLVLIL CHHHHHHHHHHHHHH	9.07	24043423
67	Phosphorylation	QTGVFYLTLVLILVT HHHHHHHHHHHHHHH	11.93	24043423
74	Phosphorylation	TLVLILVTSGLFFAF HHHHHHHHCCCHHHC	17.40	24043423
75	Phosphorylation	LVLILVTSGLFFAFD HHHHHHHCCCHHHCC	26.48	24043423
85	Phosphorylation	FFAFDCPYLAVKITP HHHCCCCHHHHHHCH	17.39	24043423
142	Phosphorylation	IDIANGTSSGGYRPP HCCCCCCCCCCCCCC	28.52	-
403	Phosphorylation	GLGTPCASLTLGPPT CCCCCCCCCCCCCCC	28.71	24719451
410	Phosphorylation	SLTLGPPTPPASMPN CCCCCCCCCCCCCCC	45.07	24275569
414	Phosphorylation	GPPTPPASMPNLAEA CCCCCCCCCCCHHHH	40.31	-
422	Phosphorylation	MPNLAEATLADVMPR CCCHHHHHHHHHCCC	17.62	24719451
440	Phosphorylation	HMGHQFLTPDEAPSP CCCCCCCCCCCCCCC	29.95	27080861
446	Phosphorylation	LTPDEAPSPPRLLAA CCCCCCCCCCCEEEC	55.36	25159151
455	Phosphorylation	PRLLAAGSPLAHSRT CCEEECCCCCCCHHH	16.41	30266825
460	Phosphorylation	AGSPLAHSRTMHVLG CCCCCCCHHHHHHHH	24.68	23403867
470	Phosphorylation	MHVLGLASQDSLHED HHHHHHHCCCCCCCH	39.29	23898821
473	Phosphorylation	LGLASQDSLHEDSVR HHHHCCCCCCCHHHH	24.80	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDH14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDH14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDH14_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDH14_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, AND MASSSPECTROMETRY.
PubMed: 18669648