ZCPW1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCPW1_HUMAN
• UniProt AC: Q9H0M4
• Protein Name: Zinc finger CW-type PWWP domain protein 1
• Gene Name: ZCWPW1
• Organism: Homo sapiens (Human).
• Sequence Length: 648
• Protein Sequence: MMTTLQNKEECGKGPKRIFAPPAQKSYSLLPCSPNSPKEETPGISSPETEARISLPKASLKKKEEKATMKNVPSREQEKKRKAQINKQAEKKEKEKSSLTNAEFEEIVQIVLQKSLQECLGMGSGLDFAETSCAQPVVSTQSDKEPGITASATDTDNANGEEVPHTQEISVSWEGEAAPEIRTSKLGQPDPAPSKKKSNRLTLSKRKKEAHEKVEKTQGGHEHRQEDRLKKTVQDHSQIRDQQKGEISGFGQCLVWVQCSFPNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPEETWTGLESDVAYASYIPGSIIWAKQYGYPWWPGMIESDPDLGEYFLFTSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQELSLELSVMKKRRNDCSQKLGVALMMAQEAEQISIQERVNLFGFWSRFNGSNSNGERKDLQLSGLNSPGSCLEKKEKEEELEKEEGEKTDPILPIRKRVKIQTQKTKPRGLGGDAGTADGRGRTLQRKIMKRSLGRKSTAPPAPRMGRKEGQGNSDSDQPGPKKKFKAPQSKALAASFSEGKEVRTVPKNLGLSACKGACPSSAKEEPRHREPLTQEAGSVPLEDEASSDLDLEQLMEDVGRELGQSGELQHSNSDGEDFPVALFGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	FAPPAQKSYSLLPCS CCCCCCCCCEECCCC	14.10	28450419
27	Phosphorylation	APPAQKSYSLLPCSP CCCCCCCCEECCCCC	15.46	23312004
28	Phosphorylation	PPAQKSYSLLPCSPN CCCCCCCEECCCCCC	30.44	28450419
33	Phosphorylation	SYSLLPCSPNSPKEE CCEECCCCCCCCCCC	25.77	24719451
36	Phosphorylation	LLPCSPNSPKEETPG ECCCCCCCCCCCCCC	40.51	28857561
41	Phosphorylation	PNSPKEETPGISSPE CCCCCCCCCCCCCHH	28.10	28857561
45	Phosphorylation	KEETPGISSPETEAR CCCCCCCCCHHHHHH	45.84	23312004
46	Phosphorylation	EETPGISSPETEARI CCCCCCCCHHHHHHH	25.49	23312004
54	Phosphorylation	PETEARISLPKASLK HHHHHHHCCCHHHHC	32.82	24719451
68	O-linked_Glycosylation	KKKEEKATMKNVPSR CHHHHHHHHCCCCHH	39.48	30379171
68	Phosphorylation	KKKEEKATMKNVPSR CHHHHHHHHCCCCHH	39.48	26074081
74	Phosphorylation	ATMKNVPSREQEKKR HHHCCCCHHHHHHHH	44.13	26074081
132	Phosphorylation	GLDFAETSCAQPVVS CCCHHHHHCCCCEEE	10.04	22210691
142	Phosphorylation	QPVVSTQSDKEPGIT CCEEECCCCCCCCCC	51.22	22210691
194	Phosphorylation	GQPDPAPSKKKSNRL CCCCCCCCCCCCCCC	60.25	25056879
231	Ubiquitination	RQEDRLKKTVQDHSQ CHHHHHHHHHHHHHH	59.53	29967540
232	Ubiquitination	QEDRLKKTVQDHSQI HHHHHHHHHHHHHHH	23.08	29967540
356	Phosphorylation	SHLDSLPSKYHVTFF HHHHHCCCCEEEEEE	51.65	24719451
438	Methylation	GSNSNGERKDLQLSG CCCCCCCCCCEEHHC	38.90	24377469
438	Dimethylation	GSNSNGERKDLQLSG CCCCCCCCCCEEHHC	38.90	-
448	Phosphorylation	LQLSGLNSPGSCLEK EEHHCCCCCCCHHHH	35.36	28348404
470	O-linked_Glycosylation	EKEEGEKTDPILPIR HHHHCCCCCCCCCCC	42.58	30379171
470	Phosphorylation	EKEEGEKTDPILPIR HHHHCCCCCCCCCCC	42.58	-
583	Phosphorylation	ACKGACPSSAKEEPR HHCCCCCCCCCCCCC	42.69	21060948
584	Phosphorylation	CKGACPSSAKEEPRH HCCCCCCCCCCCCCC	28.62	21060948
609	Phosphorylation	VPLEDEASSDLDLEQ CCCCCCCCCCCCHHH	23.49	25921289
610	Phosphorylation	PLEDEASSDLDLEQL CCCCCCCCCCCHHHH	49.60	25921289
628	Phosphorylation	VGRELGQSGELQHSN HHHHHHHCCCCCCCC	32.22	25850435
634	Phosphorylation	QSGELQHSNSDGEDF HCCCCCCCCCCCCCC	25.68	25850435
636	Phosphorylation	GELQHSNSDGEDFPV CCCCCCCCCCCCCCE	50.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCPW1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZCPW1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCPW1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZCPW1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.