ZCH24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCH24_HUMAN
• UniProt AC: Q8N2G6
• Protein Name: Zinc finger CCHC domain-containing protein 24
• Gene Name: ZCCHC24
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Protein Sequence: MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASPYGSLNNIADGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLSAIDT ------CCHHHHHCC	37.71	25002506
5	Phosphorylation	---MSLLSAIDTSAA ---CCHHHHHCCCCH	28.59	25002506
9	Phosphorylation	SLLSAIDTSAASVYQ CHHHHHCCCCHHCCC	17.72	25002506
10	Phosphorylation	LLSAIDTSAASVYQP HHHHHCCCCHHCCCH	20.35	25002506
13	Phosphorylation	AIDTSAASVYQPAQL HHCCCCHHCCCHHHH	22.52	25002506
15	Phosphorylation	DTSAASVYQPAQLLN CCCCHHCCCHHHHHH	13.29	25002506
25	Phosphorylation	AQLLNWVYLSLQDTH HHHHHHHHHHHCCHH	5.12	25002506
27	Phosphorylation	LLNWVYLSLQDTHQA HHHHHHHHHCCHHCC	13.29	25002506
31	Phosphorylation	VYLSLQDTHQASAFD HHHHHCCHHCCCCHH	11.70	25002506
35	Phosphorylation	LQDTHQASAFDAFRP HCCHHCCCCHHHCCC	23.93	25002506
65	Phosphorylation	GRPEQLGSPLHSSYL CCHHHCCCCCCHHHH	32.64	29255136
69	Phosphorylation	QLGSPLHSSYLNSFF HCCCCCCHHHHHHHH	28.50	29255136
70	Phosphorylation	LGSPLHSSYLNSFFQ CCCCCCHHHHHHHHH	23.92	29255136
71	Phosphorylation	GSPLHSSYLNSFFQL CCCCCHHHHHHHHHH	16.96	28450419
74	Phosphorylation	LHSSYLNSFFQLQRG CCHHHHHHHHHHHCC	25.50	26699800
87	Phosphorylation	RGEALSNSVYKGASP CCCHHHCCCCCCCCC	24.37	27251275
93	Phosphorylation	NSVYKGASPYGSLNN CCCCCCCCCCCCHHH	27.59	25159151
95	Phosphorylation	VYKGASPYGSLNNIA CCCCCCCCCCHHHHH	19.49	28450419
97	Phosphorylation	KGASPYGSLNNIADG CCCCCCCCHHHHHHH	23.29	28450419
106	Phosphorylation	NNIADGLSSLTEHFS HHHHHHHHHHHHHHH	28.91	27732954
107	Phosphorylation	NIADGLSSLTEHFSD HHHHHHHHHHHHHHH	44.33	27732954
153	Ubiquitination	DCPQARPKGEGLTPY CCCCCCCCCCCCCCC	65.13	-
170	Phosphorylation	KKRCFGEYKCPKCKR CCCCCCCCCCHHHCC	20.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCH24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZCH24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCH24_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZCH24_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.
PubMed: 17081983