dbPTM

ZC3HF_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3HF_DROME
UniProt AC	Q7JWR9
Protein Name	Zinc finger CCCH domain-containing protein 15 homolog
Gene Name	CG8635
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	404
Subcellular Localization
Protein Description
Protein Sequence	MPPKKAPPGPSKKTEQKKKEKVIEDKTFGLKNKKGNKQQKFIQQVQKQVQSGGQHPRQDGDKRKEEKEKKLAEQREMALIFKPVQTQKVEKGTDPKSVVCAFFKQGTCTKGDKCKFSHDLSQENKVEKRSIYVDMRDEDDPMTNWDDAKLKEVVEKKSSGEKQRPTTDIICKFFLEAVEKSKYGWFWECPNGGKCIYRHALPAGYVLKRDKKKEEKPTEISLVDLIEKERAALGPNQTRVTLESFLAWKKRKIAEKKAKLAAEEERKKSDFSKGKQFGISGREMFSFNPDLVDDGPMEEGDAAFDVYNREDDDDNAVEFKELDLAALSLAAKEVDGSGTIASTNRLLDQATEAAKTAAAEDAAADEDGPSSSAPANDAAPINKDLFVDLAGELDDLDLDDEDDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	ENKVEKRSIYVDMRD CCCCEEEEEEEECCC	29.37	19429919
132	Phosphorylation	KVEKRSIYVDMRDED CCEEEEEEEECCCCC	7.52	19429919
218	Phosphorylation	KKKEEKPTEISLVDL CCCCCCCCEEEHHHH	57.95	22817900
221	Phosphorylation	EEKPTEISLVDLIEK CCCCCEEEHHHHHHH	18.99	22817900
269	Phosphorylation	AEEERKKSDFSKGKQ HHHHHHHCHHCCCCC	47.09	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC3HF_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3HF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3HF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZC3HF_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3HF_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-218 AND SER-221, ANDMASS SPECTROMETRY.	18327897 [Abstract]