dbPTM

ZC3H4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3H4_MOUSE
UniProt AC	Q6ZPZ3
Protein Name	Zinc finger CCCH domain-containing protein 4
Gene Name	Zc3h4
Organism	Mus musculus (Mouse).
Sequence Length	1304
Subcellular Localization
Protein Description
Protein Sequence	MEAVPGTPPPPPSESPPPPSPPPPSTPSPPPCSPDGRAATPHLLHHRLPLPDDREDGELEEGELEDDGAEEVQDPPGGQERSRKEKGEKHHSDSEEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKSHRKYRDYSPPYAPSHQQYSSSHNAPLPKKSYSKMDSKGYSMYEDYENEQYGEYEGDEEEDMGKEDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGEHPEDEEDLYEEEIEYGESEEPMGDDDYDDYSKELNQYRRSKDSRGRGLSRGRGRGSRGGRGKGMGRGRGRGGRGGMSKGGMNDDEDFYDDDMGDGGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMSLPTHEPLSPQQLQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPSGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYPQQEGMEMEPGLVGDAEDYGHYEELPGQPGEPLFPEHPLEPDSFPEGGPPGRPKAGAGVPDFLPSAQRALYLRIQQKQQEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGEPSSSGLGDPRLQKGHPTGSRLSDPRLSRDPRLSRHAETSGGSGPGDSGPSDPRLARALPTSKAEGSLHSSPAGPSSSKGQPPAEEEEGERALREKAVNIPLDPLPGHPLRDPRSQLQQFSHIKKDVTLSKPSFARTVLWNPEDLIPLPIPKQDVPPVPAALQSLPALDPRLHRSTPPGPPNTRQRPGSTDPSTSGSNLPDFELLSRILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPADPVAASRAAKPCPTEASPPAASPSGDSSPPATAPYDPRVLAAGGLGQGSSSGQSSVLSGISLYDPRTPNAGGKTAEPASDTSAQPKGPEGNGKGSASKAKEPPFVRKSALEQPETGKASTDGATATDRYNSYNRPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVKPAPKTGTGSPFAGNSPAREGEQDAGSLKDVFKGFDPTASPFCQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GTPPPPPSESPPPPS CCCCCCCCCCCCCCC	57.38	25293948
15	Phosphorylation	PPPPPSESPPPPSPP CCCCCCCCCCCCCCC	47.23	25293948
20	Phosphorylation	SESPPPPSPPPPSTP CCCCCCCCCCCCCCC	56.67	25293948
25	Phosphorylation	PPSPPPPSTPSPPPC CCCCCCCCCCCCCCC	59.74	25293948
26	Phosphorylation	PSPPPPSTPSPPPCS CCCCCCCCCCCCCCC	33.29	25293948
28	Phosphorylation	PPPPSTPSPPPCSPD CCCCCCCCCCCCCCC	50.56	25293948
33	Phosphorylation	TPSPPPCSPDGRAAT CCCCCCCCCCCCCCC	31.62	25293948
40	Phosphorylation	SPDGRAATPHLLHHR CCCCCCCCCCHHCCC	15.40	25521595
92	Phosphorylation	EKGEKHHSDSEEEKS HHCCCCCCCCHHHHH	42.42	27087446
94	Phosphorylation	GEKHHSDSEEEKSHR CCCCCCCCHHHHHHH	50.34	27087446
99	Phosphorylation	SDSEEEKSHRRLKRK CCCHHHHHHHHHHHH	26.04	28066266
110	Phosphorylation	LKRKRKKEREKEKRR HHHHHHHHHHHHHHH	69.93	24719451
131	Phosphorylation	SKHKRHASSSDDFSD HHHHHHCCCCCCCCC	25.01	25195567
132	Phosphorylation	KHKRHASSSDDFSDF HHHHHCCCCCCCCCC	38.27	25195567
133	Phosphorylation	HKRHASSSDDFSDFS HHHHCCCCCCCCCCC	38.41	25195567
137	Phosphorylation	ASSSDDFSDFSDDSD CCCCCCCCCCCCCCC	44.75	26525534
140	Phosphorylation	SDDFSDFSDDSDFSP CCCCCCCCCCCCCCC	45.56	26525534
143	Phosphorylation	FSDFSDDSDFSPSEK CCCCCCCCCCCCCHH	45.61	26525534
146	Phosphorylation	FSDDSDFSPSEKSHR CCCCCCCCCCHHHHH	32.29	25195567
155	Phosphorylation	SEKSHRKYRDYSPPY CHHHHHCCCCCCCCC	14.52	27087446
158	Phosphorylation	SHRKYRDYSPPYAPS HHHCCCCCCCCCCCC	17.68	27742792
159	Phosphorylation	HRKYRDYSPPYAPSH HHCCCCCCCCCCCCH	24.56	27087446
162	Phosphorylation	YRDYSPPYAPSHQQY CCCCCCCCCCCHHCC	34.23	25619855
165	Phosphorylation	YSPPYAPSHQQYSSS CCCCCCCCHHCCCCC	26.25	25619855
169	Phosphorylation	YAPSHQQYSSSHNAP CCCCHHCCCCCCCCC	12.16	25619855
170	Phosphorylation	APSHQQYSSSHNAPL CCCHHCCCCCCCCCC	22.49	25619855
171	Phosphorylation	PSHQQYSSSHNAPLP CCHHCCCCCCCCCCC	30.59	25619855
172	Phosphorylation	SHQQYSSSHNAPLPK CHHCCCCCCCCCCCC	18.15	25619855
196	Phosphorylation	GYSMYEDYENEQYGE CCCCHHHHCCCCCCC	14.55	-
201	Phosphorylation	EDYENEQYGEYEGDE HHHCCCCCCCCCCCC	13.02	-
204	Phosphorylation	ENEQYGEYEGDEEED CCCCCCCCCCCCCHH	22.35	-
599	Methylation	LAEKLGVRFPGPGGP HHHHHCCCCCCCCCC	30.18	24129315
599	Asymmetric dimethylarginine	LAEKLGVRFPGPGGP HHHHHCCCCCCCCCC	30.18	-
780	Phosphorylation	PSAQRALYLRIQQKQ HHHHHHHHHHHHHHH	7.92	29899451
811	Phosphorylation	RENEEGDTGNWYSSD HCCCCCCCCCCCCCC	43.18	21149613
815	Phosphorylation	EGDTGNWYSSDEDEG CCCCCCCCCCCCCCC	11.42	21149613
816	Phosphorylation	GDTGNWYSSDEDEGG CCCCCCCCCCCCCCC	23.95	27087446
817	Phosphorylation	DTGNWYSSDEDEGGS CCCCCCCCCCCCCCH	29.35	27087446
824	Phosphorylation	SDEDEGGSSVTSILK CCCCCCCHHHHHHHH	32.27	29899451
825	Phosphorylation	DEDEGGSSVTSILKT CCCCCCHHHHHHHHH	32.46	25293948
827	Phosphorylation	DEGGSSVTSILKTLR CCCCHHHHHHHHHHH	16.40	25293948
828	Phosphorylation	EGGSSVTSILKTLRQ CCCHHHHHHHHHHHH	24.62	29550500
885	Phosphorylation	RLSRHAETSGGSGPG CHHHCCCCCCCCCCC	33.19	17203969
886	Phosphorylation	LSRHAETSGGSGPGD HHHCCCCCCCCCCCC	32.44	17203969
889	Phosphorylation	HAETSGGSGPGDSGP CCCCCCCCCCCCCCC	45.39	17203969
897	Phosphorylation	GPGDSGPSDPRLARA CCCCCCCCCHHHHHH	64.87	17203969
913	Phosphorylation	PTSKAEGSLHSSPAG CCCCCCCCCCCCCCC	17.89	26060331
916	Phosphorylation	KAEGSLHSSPAGPSS CCCCCCCCCCCCCCC	43.22	21082442
917	Phosphorylation	AEGSLHSSPAGPSSS CCCCCCCCCCCCCCC	14.18	26824392
922	Phosphorylation	HSSPAGPSSSKGQPP CCCCCCCCCCCCCCC	46.45	20139300
923	Phosphorylation	SSPAGPSSSKGQPPA CCCCCCCCCCCCCCH	38.92	25367039
924	Phosphorylation	SPAGPSSSKGQPPAE CCCCCCCCCCCCCHH	45.18	25367039
1021	Phosphorylation	LDPRLHRSTPPGPPN CCCCCCCCCCCCCCC	34.22	26643407
1022	Phosphorylation	DPRLHRSTPPGPPNT CCCCCCCCCCCCCCC	33.20	25266776
1035	Phosphorylation	NTRQRPGSTDPSTSG CCCCCCCCCCCCCCC	32.11	29514104
1036	Phosphorylation	TRQRPGSTDPSTSGS CCCCCCCCCCCCCCC	58.82	28285833
1055	Phosphorylation	FELLSRILKTVNVNT HHHHHHHHHHCCCCC	3.55	24719451
1060	Phosphorylation	RILKTVNVNTPGQSE HHHHHCCCCCCCCCC	7.99	24719451
1066	Phosphorylation	NVNTPGQSEKPSDPR CCCCCCCCCCCCCCC	54.20	24719451
1101	Phosphorylation	RAAKPCPTEASPPAA HCCCCCCCCCCCCCC	51.40	23684622
1104	Phosphorylation	KPCPTEASPPAASPS CCCCCCCCCCCCCCC	25.78	27087446
1109	Phosphorylation	EASPPAASPSGDSSP CCCCCCCCCCCCCCC	23.00	27087446
1111	Phosphorylation	SPPAASPSGDSSPPA CCCCCCCCCCCCCCC	53.38	23527152
1114	Phosphorylation	AASPSGDSSPPATAP CCCCCCCCCCCCCCC	48.55	27742792
1115	Phosphorylation	ASPSGDSSPPATAPY CCCCCCCCCCCCCCC	39.38	26824392
1119	Phosphorylation	GDSSPPATAPYDPRV CCCCCCCCCCCCHHH	33.66	27742792
1122	Phosphorylation	SPPATAPYDPRVLAA CCCCCCCCCHHHEEE	35.79	27087446
1221	Phosphorylation	DRYNSYNRPRPKATA HHCCCCCCCCCCCCC	22.00	24719451
1227	Phosphorylation	NRPRPKATAAPTAAS CCCCCCCCCCCCCCC	29.49	25159016
1231	Phosphorylation	PKATAAPTAASSTPP CCCCCCCCCCCCCCC	30.08	25159016
1234	Phosphorylation	TAAPTAASSTPPPEG CCCCCCCCCCCCCCC	32.08	26239621
1235	Phosphorylation	AAPTAASSTPPPEGA CCCCCCCCCCCCCCC	39.96	22942356
1236	Phosphorylation	APTAASSTPPPEGAT CCCCCCCCCCCCCCC	37.00	26824392
1243	Phosphorylation	TPPPEGATPQPGVHN CCCCCCCCCCCCCCC	33.06	25159016
1255	Phosphorylation	VHNLPVPTLFGTVKP CCCCCCCCCEEEEEC	34.65	25159016
1259	Phosphorylation	PVPTLFGTVKPAPKT CCCCCEEEEECCCCC	20.30	25159016
1266	Phosphorylation	TVKPAPKTGTGSPFA EEECCCCCCCCCCCC	38.63	27087446
1268	Phosphorylation	KPAPKTGTGSPFAGN ECCCCCCCCCCCCCC	39.45	25521595
1270	Phosphorylation	APKTGTGSPFAGNSP CCCCCCCCCCCCCCC	19.38	27087446
1276	Phosphorylation	GSPFAGNSPAREGEQ CCCCCCCCCCCCCCC	21.01	27087446
1287	Phosphorylation	EGEQDAGSLKDVFKG CCCCCCCCHHHHHCC	33.69	27742792
1298	Phosphorylation	VFKGFDPTASPFCQ- HHCCCCCCCCCCCC-	41.43	28066266
1300	Phosphorylation	KGFDPTASPFCQ--- CCCCCCCCCCCC---	22.46	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC3H4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3H4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3H4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZC3H4_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3H4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND SER-94, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1104; SER-1109 ANDSER-1276, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-897, AND MASSSPECTROMETRY.	17203969 [Abstract]