ZC12D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZC12D_HUMAN
• UniProt AC: A2A288
• Protein Name: Probable ribonuclease ZC3H12D
• Gene Name: ZC3H12D
• Organism: Homo sapiens (Human).
• Sequence Length: 527
• Subcellular Localization: Cytoplasm, P-body . Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).; Isoform 1: Cytoplasm. Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1,
• Protein Description: May regulate cell growth likely by suppressing RB1 phosphorylation. [PubMed: 19531561 May function as RNase and regulate the levels of target RNA species (Potential In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages]
• Protein Sequence: MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MEHPSKMEFFQKL --CCCHHHHHHHHHH	47.07	7978613
135	Phosphorylation	YIKVFVPSWRKDPPR EEEEECCHHHCCCCC	33.92	26091039
182	Phosphorylation	LVCYDDRYIVKVAYE EEEECCCEEEEEEEE	19.63	18083107
196	Phosphorylation	EQDGVIVSNDNYRDL EECCEEECCCCCHHH	27.60	29116813
200	Phosphorylation	VIVSNDNYRDLQSEN EEECCCCCHHHHHCC	14.36	29978859
336	Phosphorylation	SLPPARGSPDLAALR CCCCCCCCCCHHHHH	15.08	28674151
345	Phosphorylation	DLAALRGSFSRLAFS CHHHHHCCHHHHEEC	17.39	28348404
347	Phosphorylation	AALRGSFSRLAFSDD HHHHCCHHHHEECCC	28.25	28348404
372	Methylation	PACSLTPRLGGPDWV CCCCCCCCCCCCCCC	40.50	115383201
384	Methylation	DWVSAGGRVPGPLSL CCCCCCCCCCCCCCC	30.46	115383205
414	Methylation	PGLQLQPRGEHRPRD CCCCCCCCCCCCCCC	50.61	115383209
428	Phosphorylation	DLHGDLLSPRRPPDD CCCCCCCCCCCCCCC	24.53	28450419
462	Phosphorylation	PAWGDGATGGLSVYA CCCCCCCCCCEEEEE	36.99	-
468	Phosphorylation	ATGGLSVYATEDDEG CCCCEEEEEECCCCC	12.39	-
505	Phosphorylation	MAAFPELSDLARLIL HHHCCCHHHHHHHHH	28.99	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZC12D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZC12D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZC12D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZC12A_HUMAN	ZC3H12A	physical	26134560

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.