ZBT7B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT7B_MOUSE
• UniProt AC: Q64321
• Protein Name: Zinc finger and BTB domain-containing protein 7B {ECO:0000305}
• Gene Name: Zbtb7b {ECO:0000312|MGI:MGI:102755}
• Organism: Mus musculus (Mouse).
• Sequence Length: 544
• Subcellular Localization: Nucleus .
• Protein Description: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. [PubMed: 15729333]
• Protein Sequence: MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGTVMGTGGGGTASGGAGAGVCELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERARQYLEAFATATTTASTSGMPNGEDSPPQVPLLPPPPPPPRPVARRSRKPRKAFLQTKGARANHLVPEAPTVLTHPLTYEEEEMVGRLGNSGGSGLGDSYSPPTGAASPAEGPLNYEVFEGEEEEEEMAYPPGYGLAQSNEPSLSPEELGSDEDPIDPDLMAYLSSLHQDALTPGLDGQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDKLKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQRHLKGQNCLEVRTRRRRKDDVAAPHYPPPSTTTSSPAGLDLSNGHLDTFHLSLARFWEQSATTGPPVTTQGPPEEEEEEGTPTTPQAEGAMESS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSPEDDLIG -----CCCCHHHCCC	24.66	30352176
150	Phosphorylation	GSGLEAPSPDEDDCE CCCCCCCCCCHHHHH	52.62	-
210	Ubiquitination	RRSRKPRKAFLQTKG CCCCCCCHHHHHCCC	52.60	PubMed
210	Acetylation	RRSRKPRKAFLQTKG CCCCCCCHHHHHCCC	52.60	20810990
216	Ubiquitination	RKAFLQTKGARANHL CHHHHHCCCHHHCCC	37.30	PubMed
216	Acetylation	RKAFLQTKGARANHL CHHHHHCCCHHHCCC	37.30	20810990
339	Ubiquitination	PGLDGQDKLVRKRRS CCCCHHHHHHHHHHH	40.78	PubMed
339	Acetylation	PGLDGQDKLVRKRRS CCCCHHHHHHHHHHH	40.78	20810990
346	Phosphorylation	KLVRKRRSQMPQECP HHHHHHHHCCCCCCH	34.56	-
373	Phosphorylation	PRHMRTHTGEKPFAC CCCCCCCCCCCCEEE	46.56	-
429	Phosphorylation	KNHMHLHTGDRPYEC CCCCEEECCCCCCCC	47.33	-
454	Ubiquitination	DHLQRHLKGQNCLEV HHHHHHHCCCCCHHH	52.94	-
480	Phosphorylation	APHYPPPSTTTSSPA CCCCCCCCCCCCCCC	44.13	26060331
481	Phosphorylation	PHYPPPSTTTSSPAG CCCCCCCCCCCCCCC	39.61	26060331
482	Phosphorylation	HYPPPSTTTSSPAGL CCCCCCCCCCCCCCC	29.08	26060331
483	Phosphorylation	YPPPSTTTSSPAGLD CCCCCCCCCCCCCCC	27.56	26060331
484	Phosphorylation	PPPSTTTSSPAGLDL CCCCCCCCCCCCCCC	32.03	26060331
485	Phosphorylation	PPSTTTSSPAGLDLS CCCCCCCCCCCCCCC	19.37	26060331
531	Phosphorylation	EEEEEEGTPTTPQAE HHHHCCCCCCCHHHC	22.27	30482847
533	Phosphorylation	EEEEGTPTTPQAEGA HHCCCCCCCHHHCCC	51.45	25338131
534	Phosphorylation	EEEGTPTTPQAEGAM HCCCCCCCHHHCCCC	18.01	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT7B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
210	K	Acetylation	Competes with acetylation on Lys-210, Lys-216 and Lys-339.	20810990
210	K	Acetylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990
210	K	ubiquitylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990
216	K	Acetylation	Competes with acetylation on Lys-210, Lys-216 and Lys-339.	20810990
216	K	Acetylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990
216	K	ubiquitylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990
339	K	Acetylation	Competes with acetylation on Lys-210, Lys-216 and Lys-339.	20810990
339	K	Acetylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990
339	K	ubiquitylation	EP300-mediated acetylation of Lys-210, Lys-216 and Lys-339 stabilizes the protein by antagonizing ubiquitin conjugation.	20810990

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT7B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZBT7B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.