ZBT18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT18_MOUSE
• UniProt AC: Q9WUK6
• Protein Name: Zinc finger and BTB domain-containing protein 18
• Gene Name: Zbtb18
• Organism: Mus musculus (Mouse).
• Sequence Length: 522
• Subcellular Localization: Nucleus. Associates with condensed chromatin.
• Protein Description: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus..
• Protein Sequence: MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHMAGDLPSDEDEGEDDKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMENSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Acetylation	KVCKKKLKEKATTEA HHHHHHHHHHCCCCC		6571697
120	Acetylation	CKKKLKEKATTEADS HHHHHHHHCCCCCCC		6571619
129	Acetylation	TTEADSTKKEEDASS CCCCCCCCHHHHHHH		6571745
157	Phosphorylation	HMAGDLPSDEDEGED CCCCCCCCCCCCCCC		25338131
211	Phosphorylation	HATAAGKTVASPCSS CCCCCCCEEECCCCC		23527152
214	Phosphorylation	AAGKTVASPCSSTES CCCCEEECCCCCCHH		25521595
217	Phosphorylation	KTVASPCSSTESLSQ CEEECCCCCCHHHHH		21183079
218	Phosphorylation	TVASPCSSTESLSQR EEECCCCCCHHHHHC		19060867
219	Phosphorylation	VASPCSSTESLSQRS EECCCCCCHHHHHCC		21183079
221	Phosphorylation	SPCSSTESLSQRSVT CCCCCCHHHHHCCCC		25293948
223	Phosphorylation	CSSTESLSQRSVTSV CCCCHHHHHCCCCCH		24719451
279	Phosphorylation	VKVEKEASCDESDVG EEEEECCCCCHHCCC		19060867
283	Phosphorylation	KEASCDESDVGTNDY ECCCCCHHCCCCCCC		29899451
321	Phosphorylation	LAPLREDSVLRELDR HHCCCCCHHHHHHCC		29899451
333	Phosphorylation	LDREDKASDDEMMTP HCCCCCCCCCCCCCC		25521595
339	Phosphorylation	ASDDEMMTPESERVQ CCCCCCCCCHHHCEE		30635358
507	Phosphorylation	SEALSLPTVRDWTLE CCCCCCCCCCCCCCC		-
516	Phosphorylation	RDWTLEDSSQELWK- CCCCCCCCHHHHCC-		-
517	Phosphorylation	DWTLEDSSQELWK-- CCCCCCCHHHHCC--		21082442
525	Phosphorylation	QELWK---------- HHHCC----------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT18_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZBT18_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.