ZBED6_HUMAN - dbPTM
ZBED6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBED6_HUMAN
UniProt AC P86452
Protein Name Zinc finger BED domain-containing protein 6 {ECO:0000303|PubMed:20016685}
Gene Name ZBED6 {ECO:0000303|PubMed:20016685}
Organism Homo sapiens (Human).
Sequence Length 979
Subcellular Localization Nucleus . Nucleus, nucleolus . Located predominantly in the nucleolus but is also dispersed throughout the nucleus.
Protein Description Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity)..
Protein Sequence MSVCTLSVPVSSLSPGRRCNTFSDSGILGCVPINSNTDEEDVVEEKMVAEGVNKEAKQPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPALLASNDPEQDEESLFESNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSRGKPGSHLGTSTLQRHLQARHSPHWTRANKFGVASGEEDFTLDVSLSPSSGSNGSFEYIPTDPLDDNRMGKKHDKSASDALRAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAVANGLDEAETERSDLLSDTLHGEKSTGSQDLTAEDLSDSDSDEPMLEVENRSESPIPVAEQGTLMRAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFSTPAFQRFMQIVAPDYRLPSETYFFTKAVPQLYDCVREKIFLTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNSSNVVHAIKDGGFTHVPCFLHCLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQKVSVKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALNLVDSLSLKLETDTLLSAMLKSKPCILATLLDPCFKNSLEDFFPQGADLETYKQFLAEEVCNYMESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSSGSVDSSAVDNVALGSKSFMFPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPALTQVAIQYLSCPMCSWQSECIFTKNSHFHPKQIMSLDFDNIEQLMFLKMNLKNVNYDYSTLVLSWDPEQNEVVQSSEKEILP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MSVCTLSVPVSSLS
-CCEEEEEEEHHHCC		13.2630257219
11PhosphorylationCTLSVPVSSLSPGRR
EEEEEEHHHCCCCCC		21.3524732914
12PhosphorylationTLSVPVSSLSPGRRC
EEEEEHHHCCCCCCC		32.8524732914
14PhosphorylationSVPVSSLSPGRRCNT
EEEHHHCCCCCCCCC		27.5330266825
21PhosphorylationSPGRRCNTFSDSGIL
CCCCCCCCCCCCCCC		28.3027251275
23PhosphorylationGRRCNTFSDSGILGC
CCCCCCCCCCCCCEE		28.9127251275
25PhosphorylationRCNTFSDSGILGCVP
CCCCCCCCCCCEEEE		26.9127251275
35PhosphorylationLGCVPINSNTDEEDV
CEEEECCCCCCHHHH		41.6528348404
37PhosphorylationCVPINSNTDEEDVVE
EEECCCCCCHHHHHH		44.6127251275
113PhosphorylationDPEQDEESLFESNIE
CHHHCHHHHHHCCHH		35.9924719451
117PhosphorylationDEESLFESNIEKQIY
CHHHHHHCCHHHEEE		35.4527732954
121UbiquitinationLFESNIEKQIYLPST
HHHCCHHHEEECCCC		37.8929967540
145PhosphorylationFFHVDPQYTWRAICN
EEECCHHHHHHHHHH		17.4125884760
146PhosphorylationFHVDPQYTWRAICNL
EECCHHHHHHHHHHH		11.8325884760
170PhosphorylationPGSHLGTSTLQRHLQ
CCCCCCHHHHHHHHH		25.89-
171PhosphorylationGSHLGTSTLQRHLQA
CCCCCHHHHHHHHHH		27.09-
181PhosphorylationRHLQARHSPHWTRAN
HHHHHHCCCCCCCCC		16.9524719451
251PhosphorylationRGRFLIKSNIVKHAL
HHCEEEECCCHHCCC		25.46-
262PhosphorylationKHALIPGTRAKTSAV
HCCCCCCCCCCCCCH		23.31-
289UbiquitinationRAVCNICKRSVSRGR
HHHHHHHHHHHHCCC		43.86-
304PhosphorylationPGSHLGTSTLQRHLQ
CCCCCCHHHHHHHHH		25.89-
305PhosphorylationGSHLGTSTLQRHLQA
CCCCCHHHHHHHHHC		27.0928555341
344PhosphorylationTERSDLLSDTLHGEK
HHHHHHHHHHHCCCC		35.5327732954
346PhosphorylationRSDLLSDTLHGEKST
HHHHHHHHHCCCCCC		19.7827732954
352PhosphorylationDTLHGEKSTGSQDLT
HHHCCCCCCCCCCCC		33.4327732954
353PhosphorylationTLHGEKSTGSQDLTA
HHCCCCCCCCCCCCH		52.5027732954
355PhosphorylationHGEKSTGSQDLTAED
CCCCCCCCCCCCHHH		22.1727732954
359PhosphorylationSTGSQDLTAEDLSDS
CCCCCCCCHHHCCCC		35.9725137130
364PhosphorylationDLTAEDLSDSDSDEP
CCCHHHCCCCCCCCC		47.6025137130
366PhosphorylationTAEDLSDSDSDEPML
CHHHCCCCCCCCCCE		35.3233259812
368PhosphorylationEDLSDSDSDEPMLEV
HHCCCCCCCCCCEEE		48.0727732954
379PhosphorylationMLEVENRSESPIPVA
CEEECCCCCCCCCHH		54.7523401153
381PhosphorylationEVENRSESPIPVAEQ
EECCCCCCCCCHHHH		29.4029255136
467MethylationLYDCVREKIFLTLEN
HHHHHHHHHEEEEEC		28.3523644510
479MethylationLENVQSQKIHLTVDI
EECHHCCEEEEEEEE		37.0223644510
617PhosphorylationRKTCHHFSHSVKARQ
HHHHHHHHHHHHHHH		15.53-
619PhosphorylationTCHHFSHSVKARQIL
HHHHHHHHHHHHHHH		24.90-
722PhosphorylationLIHHLLLSLQKLRED
HHHHHHHHHHHHHHH		28.8224719451
744PhosphorylationQALNLVDSLSLKLET
HHHHHHHHHHHHHCH		16.6324719451
746PhosphorylationLNLVDSLSLKLETDT
HHHHHHHHHHHCHHH		27.6624719451
874UbiquitinationVDEYFKEKYSEFSGG
HHHHHHHHHHHHCCC		55.4529967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZBED6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZBED6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBED6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZBED6_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBED6_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory