ZBED5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBED5_HUMAN
• UniProt AC: Q49AG3
• Protein Name: Zinc finger BED domain-containing protein 5
• Gene Name: ZBED5
• Organism: Homo sapiens (Human).
• Sequence Length: 693
• Protein Sequence: MIAPLLCILSYNFNTFAILNVYSKLTMFCTTNSLPMDLLLKQGSLKQEVESFCYQIVSESNDQKVGILQSEDKQLQPSVSKKSEGELSRVKFISNSNKITFSKKPKRRKYDESYLSFGFTYFGNRDAPHAQCVLCKKILSNSSLAPSKLRRHLETKHAAYKDKDISFFKQHLDSPENNKPPTPKIVNTDNESATEASYNVSYHIALSGEAHTIGELLIKPCAKDVVMRMFDEQYSKKIDAVQLSNSTVARRIKDLAADIEEELVCRLKICDGFSLQLDESADVSGLAVLLVFVRYRFNKSIEEDLLLCESLQSNATGEEIFNCINSFMQKHEIEWEKCVDVCSDASRAVDGKIAEAVTLIKYVAPESTSSHCLLYRHALAVKIMPTSLKNVLDQAVQIINYIKARPHQSRLLKILCEEMGAQHTALLLNTEVRWLSRGKVLVRLFELRRELLVFMDSAFRLSDCLTNSSWLLRLAYLADIFTKLNEVNLSMQGKNVTVFTVFDKMSSLLRKLEFWASSVEEENFDCFPTLSDFLTEINSTVDKDICSAIVQHLRGLRATLLKYFPVTNDNNAWVRNPFTVTVKPASLVARDYESLIDLTSDSQVKQNFSELSLNDFWSSLIQEYPSIARRAVRVLLPFATMHLCETGFSYYAATKTKYRKRLDAAPHMRIRLSNITPNIKRICDKKTQKHCSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	LNVYSKLTMFCTTNS HHHHHHHHHHHCCCC	16.37	29759185
31	Phosphorylation	KLTMFCTTNSLPMDL HHHHHHCCCCCCHHH	24.80	29759185
33	Phosphorylation	TMFCTTNSLPMDLLL HHHHCCCCCCHHHHH	31.58	29759185
78	Phosphorylation	EDKQLQPSVSKKSEG CCCCCCCCCCCCCCC	26.51	26091039
81	Ubiquitination	QLQPSVSKKSEGELS CCCCCCCCCCCCCCC	59.15	29967540
82	Ubiquitination	LQPSVSKKSEGELSR CCCCCCCCCCCCCCC	46.35	-
91	Ubiquitination	EGELSRVKFISNSNK CCCCCCEEEECCCCC	35.55	29967540
94	Phosphorylation	LSRVKFISNSNKITF CCCEEEECCCCCEEE	37.02	-
96	Phosphorylation	RVKFISNSNKITFSK CEEEECCCCCEEECC	32.48	-
98	Ubiquitination	KFISNSNKITFSKKP EEECCCCCEEECCCC	42.83	29967540
121	Phosphorylation	YLSFGFTYFGNRDAP CCCCCEEEECCCCCC	13.76	-
137	Ubiquitination	AQCVLCKKILSNSSL HHHHHHHHHHHCCCC	48.13	29967540
148	Ubiquitination	NSSLAPSKLRRHLET CCCCCCHHHHHHHHH	44.98	29967540
163	Ubiquitination	KHAAYKDKDISFFKQ HHHHHHCCCHHHHHH	53.46	29967540
169	Ubiquitination	DKDISFFKQHLDSPE CCCHHHHHHHCCCCC	34.49	29967540
174	Phosphorylation	FFKQHLDSPENNKPP HHHHHCCCCCCCCCC	40.24	28674419
182	Phosphorylation	PENNKPPTPKIVNTD CCCCCCCCCCCCCCC	45.82	28674419
212	Phosphorylation	ALSGEAHTIGELLIK EECCCCEEHHHHHHH	37.41	19007248
234	Phosphorylation	MRMFDEQYSKKIDAV HHHCCHHHHCCCCEE	22.02	-
236	Ubiquitination	MFDEQYSKKIDAVQL HCCHHHHCCCCEEEC	49.14	29967540
237	Ubiquitination	FDEQYSKKIDAVQLS CCHHHHCCCCEEECC	39.62	29967540
246	Phosphorylation	DAVQLSNSTVARRIK CEEECCCHHHHHHHH	22.38	20860994
247	Phosphorylation	AVQLSNSTVARRIKD EEECCCHHHHHHHHH	23.57	-
253	Ubiquitination	STVARRIKDLAADIE HHHHHHHHHHHCHHH	44.90	29967540
313	Phosphorylation	LLCESLQSNATGEEI HHHHHHCCCCCHHHH	33.45	30576142
337	Ubiquitination	KHEIEWEKCVDVCSD HCCCCHHHHHHHHCH	40.40	29967540
362	Phosphorylation	EAVTLIKYVAPESTS HHHHHHHHHCCCCCC	8.54	-
375	Phosphorylation	TSSHCLLYRHALAVK CCHHHHHHHHHHHHH	6.34	-
457	Phosphorylation	ELLVFMDSAFRLSDC HHHHHHHHCHHHHHH	19.95	26852163
476	Phosphorylation	SWLLRLAYLADIFTK HHHHHHHHHHHHHHH	13.65	25219547
482	Phosphorylation	AYLADIFTKLNEVNL HHHHHHHHHHHHCCH	34.65	24719451
490	Phosphorylation	KLNEVNLSMQGKNVT HHHHCCHHHCCCCEE	12.12	29449344
507	Phosphorylation	TVFDKMSSLLRKLEF EEHHHHHHHHHHHHH	28.11	24719451
583	Ubiquitination	NPFTVTVKPASLVAR CCEEEEECCHHHHCC	26.04	29967540
592	Phosphorylation	ASLVARDYESLIDLT HHHHCCCHHHHHHCC	11.23	-
594	Phosphorylation	LVARDYESLIDLTSD HHCCCHHHHHHCCCH	25.13	-
656	Phosphorylation	SYYAATKTKYRKRLD CEEEECCHHHHHHHC	29.02	20860994
673	Phosphorylation	PHMRIRLSNITPNIK CCCEEECCCCCCCHH	19.15	-
680	Ubiquitination	SNITPNIKRICDKKT CCCCCCHHHHHCCCC	42.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBED5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBED5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBED5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZBED5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-212, AND MASSSPECTROMETRY.
PubMed: 19007248