ZBED3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBED3_MOUSE
• UniProt AC: Q9D0L1
• Protein Name: Zinc finger BED domain-containing protein 3
• Gene Name: Zbed3
• Organism: Mus musculus (Mouse).
• Sequence Length: 228
• Subcellular Localization: Cytoplasm . Membrane . Colocalizes with AXIN1 in the cytoplasm.
• Protein Description: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression..
• Protein Sequence: MKSKKPLKITMEDSRRLNDPAEQGGLCPAPVGPSYSEAWGYFHLDPAQPRHRMMSAWATCRLCGLQVGGLPNFQMWTRALCQHLSDVHLPELKKSAAPSSPTTMPCPPPPSPTMAAEGDWARLLEQMGELAMRGSQRELELERREAALMQAELELERKRQALKQEAQSVEQERHQLQVEREALSKWIKKQSPGAQVPEPPSPLPLLPKEDPDIHDNNSDNDMVTKVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	HLPELKKSAAPSSPT CHHHHHHCCCCCCCC		26745281
99	Phosphorylation	LKKSAAPSSPTTMPC HHHCCCCCCCCCCCC		26745281
100	Phosphorylation	KKSAAPSSPTTMPCP HHCCCCCCCCCCCCC		26745281
102	Phosphorylation	SAAPSSPTTMPCPPP CCCCCCCCCCCCCCC		26745281
103	Phosphorylation	AAPSSPTTMPCPPPP CCCCCCCCCCCCCCC		26745281
111	Phosphorylation	MPCPPPPSPTMAAEG CCCCCCCCCCCCCCC		25266776
113	Phosphorylation	CPPPPSPTMAAEGDW CCCCCCCCCCCCCHH		26745281
168	Phosphorylation	ALKQEAQSVEQERHQ HHHHHHHHHHHHHHH		29899451
191	Phosphorylation	SKWIKKQSPGAQVPE HHHHHHHCCCCCCCC		26824392
201	Phosphorylation	AQVPEPPSPLPLLPK CCCCCCCCCCCCCCC		27180971
218	Phosphorylation	PDIHDNNSDNDMVTK CCCCCCCCCCCCCHH		23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
111	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
111	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
113	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
113	T	Phosphorylation	Kinase	CSNK1E	P49674	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBED3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBED3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZBED3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.