| UniProt ID | ZBED3_HUMAN | |
|---|---|---|
| UniProt AC | Q96IU2 | |
| Protein Name | Zinc finger BED domain-containing protein 3 | |
| Gene Name | ZBED3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 234 | |
| Subcellular Localization | Cytoplasm. Membrane. Colocalizes with AXIN1 in the cytoplasm.. | |
| Protein Description | Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).. | |
| Protein Sequence | MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAPYSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELESSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKDDPEGDRDGCVITKVLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Methylation | GLDDAAARGGQCPGL CHHHHHHCCCCCCCC | 45.08 | 115388091 | |
| 34 | Phosphorylation | PGLGPAPTPTPPGRL CCCCCCCCCCCCCCC | 41.73 | 24719451 | |
| 51 | Phosphorylation | PYSEAWGYFHLAPGR CHHHHHEEEEECCCC | 4.15 | 24719451 | |
| 103 | Phosphorylation | AHRRELESSGAGSSP HHHHHHHHCCCCCCC | 46.85 | 27690223 | |
| 104 | Phosphorylation | HRRELESSGAGSSPP HHHHHHHCCCCCCCC | 24.24 | 21712546 | |
| 108 | Phosphorylation | LESSGAGSSPPAAPC HHHCCCCCCCCCCCC | 38.85 | 28348404 | |
| 109 | Phosphorylation | ESSGAGSSPPAAPCP HHCCCCCCCCCCCCC | 33.70 | 17192257 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZBED3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZBED3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZBED3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ZBED3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY. | |
