dbPTM

Z280D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	Z280D_HUMAN
UniProt AC	Q6N043
Protein Name	Zinc finger protein 280D
Gene Name	ZNF280D
Organism	Homo sapiens (Human).
Sequence Length	979
Subcellular Localization	Nucleus .
Protein Description	May function as a transcription factor..
Protein Sequence	MGDNPFQPKSNSKMAELFMECEEEELEPWQKKVKEVEDDDDDEPIFVGEISSSKPAISNILNRVNPSSYSRGLKNGALSRGITAAFKPTSQHYTNPTSNPVPASPINFHPESRSSDSSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGGPTLSMAGMSESSFLSKRPSTSEVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQAMLAKGTNTSSNQSKNGTPFPRACPKCNIHFNLLDPLKNHMKYCCPDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFYYGKHEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKICELSFETEHVLLQHMKDNHKPGEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLEGLPPGTKVTIRASVGPLQSGASPTPSISASASTLQLSPPRTKNITAKNPAKSNTSKPNTVKSNASKPNTSKPNGSKSKYKPKISNMQKKQSTLASSNKKSKVNTALRNLRYRRGIHKCIECCSEIKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRFCIFKKHSENLRGITLVCLNCDFLSDVSGLDNMATHLSQHKTHTCQVVMQKVSVCIPTSEHLSELKKEAPAKEQEPVSKEIARPNMAERETETSNSESKQDKAASSKEKNGCNANSFEGSSTTKSEESITVSDKENETCLADQETGSKNIVSCDSNIGADKVEKKKQIQHVCQEMELKMCQSSENIILSDQIKDHNSSEARFSSKNIKDLRLASDNVSIDQFLRKRHEPESVSSDVSEQGSIHLEPLTPSEVLEYEATEILQKGSGDPSAKTDEVVSDQTDDIPGGNNPSTTEATVDLEDEKERS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DNPFQPKSNSKMAEL CCCCCCCCCCHHHHH	53.68	30619164
21	Glutathionylation	MAELFMECEEEELEP HHHHHHHHCHHHCHH	5.53	22555962
32	Acetylation	ELEPWQKKVKEVEDD HCHHHHHHHHCCCCC	43.36	19807407
32	Sumoylation	ELEPWQKKVKEVEDD HCHHHHHHHHCCCCC	43.36	28112733
34	Sumoylation	EPWQKKVKEVEDDDD HHHHHHHHCCCCCCC	65.99	-
34	Sumoylation	EPWQKKVKEVEDDDD HHHHHHHHCCCCCCC	65.99	28112733
54	Acetylation	VGEISSSKPAISNIL EEEECCCCHHHHHHH	40.18	26051181
54	Ubiquitination	VGEISSSKPAISNIL EEEECCCCHHHHHHH	40.18	-
71	Methylation	VNPSSYSRGLKNGAL CCHHHHHHHCCCCCC	46.35	80702261
74	Sumoylation	SSYSRGLKNGALSRG HHHHHHCCCCCCCCC	57.04	-
74	Sumoylation	SSYSRGLKNGALSRG HHHHHHCCCCCCCCC	57.04	28112733
83	Phosphorylation	GALSRGITAAFKPTS CCCCCCCCCEECCCC	18.11	27251275
87	Sumoylation	RGITAAFKPTSQHYT CCCCCEECCCCCCCC	42.53	-
87	Acetylation	RGITAAFKPTSQHYT CCCCCEECCCCCCCC	42.53	25953088
87	Sumoylation	RGITAAFKPTSQHYT CCCCCEECCCCCCCC	42.53	28112733
89	Phosphorylation	ITAAFKPTSQHYTNP CCCEECCCCCCCCCC	41.42	27251275
90	Phosphorylation	TAAFKPTSQHYTNPT CCEECCCCCCCCCCC	24.40	27251275
93	Phosphorylation	FKPTSQHYTNPTSNP ECCCCCCCCCCCCCC	10.69	27251275
94	Phosphorylation	KPTSQHYTNPTSNPV CCCCCCCCCCCCCCC	32.37	26074081
97	Phosphorylation	SQHYTNPTSNPVPAS CCCCCCCCCCCCCCC	43.11	29978859
98	Phosphorylation	QHYTNPTSNPVPASP CCCCCCCCCCCCCCC	40.15	28152594
104	Phosphorylation	TSNPVPASPINFHPE CCCCCCCCCCCCCCC	21.90	23401153
112	Phosphorylation	PINFHPESRSSDSSV CCCCCCCCCCCCCCE	41.74	28152594
114	Phosphorylation	NFHPESRSSDSSVIV CCCCCCCCCCCCEEE	48.02	26074081
115	Phosphorylation	FHPESRSSDSSVIVQ CCCCCCCCCCCEEEE	40.16	26074081
117	Phosphorylation	PESRSSDSSVIVQPF CCCCCCCCCEEEECC	28.58	26074081
118	Phosphorylation	ESRSSDSSVIVQPFS CCCCCCCCEEEECCC	22.36	26074081
126	Sumoylation	VIVQPFSKPGYITNS EEEECCCCCCEECCC	42.72	-
126	Sumoylation	VIVQPFSKPGYITNS EEEECCCCCCEECCC	42.72	28112733
140	Sumoylation	SSRVVSNKSSELLFD CCCEECCCCCHHEEE	48.10	28112733
179	Phosphorylation	SFLSKRPSTSEVNNV HHHCCCCCCCCCCCC	48.90	28387310
180	Phosphorylation	FLSKRPSTSEVNNVN HHCCCCCCCCCCCCC	31.43	28985074
181	Phosphorylation	LSKRPSTSEVNNVNP HCCCCCCCCCCCCCC	43.83	30206219
189	Sumoylation	EVNNVNPKKPKPSES CCCCCCCCCCCCCCC	76.21	28112733
194	Phosphorylation	NPKKPKPSESVSGAN CCCCCCCCCCCCCCC	48.94	20068231
196	Phosphorylation	KKPKPSESVSGANSS CCCCCCCCCCCCCCC	26.39	20068231
198	Phosphorylation	PKPSESVSGANSSAV CCCCCCCCCCCCCCC	41.28	20068231
202	Phosphorylation	ESVSGANSSAVLPSV CCCCCCCCCCCCCCC	21.09	20068231
203	Phosphorylation	SVSGANSSAVLPSVK CCCCCCCCCCCCCCC	23.39	20068231
208	Phosphorylation	NSSAVLPSVKSPSVT CCCCCCCCCCCCCCC	37.71	20068231
210	Sumoylation	SAVLPSVKSPSVTSS CCCCCCCCCCCCCHH	62.07	-
210	Sumoylation	SAVLPSVKSPSVTSS CCCCCCCCCCCCCHH	62.07	28112733
211	Phosphorylation	AVLPSVKSPSVTSSQ CCCCCCCCCCCCHHH	21.91	22199227
213	Phosphorylation	LPSVKSPSVTSSQAM CCCCCCCCCCHHHHH	45.15	23312004
215	Phosphorylation	SVKSPSVTSSQAMLA CCCCCCCCHHHHHHH	27.31	23532336
216	Phosphorylation	VKSPSVTSSQAMLAK CCCCCCCHHHHHHHC	20.49	23312004
217	Phosphorylation	KSPSVTSSQAMLAKG CCCCCCHHHHHHHCC	16.76	23312004
223	Sumoylation	SSQAMLAKGTNTSSN HHHHHHHCCCCCCCC	63.41	-
223	Sumoylation	SSQAMLAKGTNTSSN HHHHHHHCCCCCCCC	63.41	28112733
233	Sumoylation	NTSSNQSKNGTPFPR CCCCCCCCCCCCCCC	50.02	-
233	Sumoylation	NTSSNQSKNGTPFPR CCCCCCCCCCCCCCC	50.02	28112733
261	Phosphorylation	PLKNHMKYCCPDMIN HHHHHHHHHCHHHHH	7.54	-
275	Sumoylation	NNFLGLAKTEFSSTV HHHHHHHHCCHHCCC	54.34	28112733
284	Sumoylation	EFSSTVNKNTTIDSE CHHCCCCCCCEEECC	51.87	28112733
284	Ubiquitination	EFSSTVNKNTTIDSE CHHCCCCCCCEEECC	51.87	-
292	Sumoylation	NTTIDSEKGKLIMLV CCEEECCCCCEEEEE	66.36	-
292	Sumoylation	NTTIDSEKGKLIMLV CCEEECCCCCEEEEE	66.36	25218447
413 (in isoform 4)	Phosphorylation	-	36.10	22210691
418 (in isoform 4)	Phosphorylation	-	16.73	22210691
431	Phosphorylation	NYRSSSFSDVETHFR CCCCCCCHHHHHHCC	42.57	-
460	Phosphorylation	LKVIKIATPYMHHYM HHHHHHHHHHHHHHH	20.58	25219547
462	Phosphorylation	VIKIATPYMHHYMKH HHHHHHHHHHHHHHH	12.53	25219547
466	Phosphorylation	ATPYMHHYMKHQKKG HHHHHHHHHHHHCCC	7.99	25219547
514	Phosphorylation	LEGLPPGTKVTIRAS CCCCCCCCEEEEEEE	28.28	25159151
517	Phosphorylation	LPPGTKVTIRASVGP CCCCCEEEEEEECCC	13.29	24719451
521	Phosphorylation	TKVTIRASVGPLQSG CEEEEEEECCCCCCC	20.12	20068231
527	Phosphorylation	ASVGPLQSGASPTPS EECCCCCCCCCCCCC	43.97	20068231
530	Phosphorylation	GPLQSGASPTPSISA CCCCCCCCCCCCCCC	32.60	25159151
532	Phosphorylation	LQSGASPTPSISASA CCCCCCCCCCCCCCC	27.46	20068231
534	Phosphorylation	SGASPTPSISASAST CCCCCCCCCCCCCCC	31.49	20068231
536	Phosphorylation	ASPTPSISASASTLQ CCCCCCCCCCCCCCC	22.10	28450419
538	Phosphorylation	PTPSISASASTLQLS CCCCCCCCCCCCCCC	18.89	28152594
540	Phosphorylation	PSISASASTLQLSPP CCCCCCCCCCCCCCC	27.44	28152594
541	Phosphorylation	SISASASTLQLSPPR CCCCCCCCCCCCCCC	20.45	26657352
545	Phosphorylation	SASTLQLSPPRTKNI CCCCCCCCCCCCCCC	21.64	30266825
549	Phosphorylation	LQLSPPRTKNITAKN CCCCCCCCCCCCCCC	33.93	28152594
550	Sumoylation	QLSPPRTKNITAKNP CCCCCCCCCCCCCCC	47.86	28112733
559	Methylation	ITAKNPAKSNTSKPN CCCCCCCCCCCCCCC	45.56	24129315
570	Phosphorylation	SKPNTVKSNASKPNT CCCCCCCCCCCCCCC	33.04	26074081
573	Phosphorylation	NTVKSNASKPNTSKP CCCCCCCCCCCCCCC	53.55	26074081
577	Phosphorylation	SNASKPNTSKPNGSK CCCCCCCCCCCCCCC	46.81	26074081
578	Phosphorylation	NASKPNTSKPNGSKS CCCCCCCCCCCCCCC	53.40	26074081
583	Phosphorylation	NTSKPNGSKSKYKPK CCCCCCCCCCCCCCC	40.16	26074081
585	Phosphorylation	SKPNGSKSKYKPKIS CCCCCCCCCCCCCCC	42.80	26074081
587	Phosphorylation	PNGSKSKYKPKISNM CCCCCCCCCCCCCHH	39.35	26074081
599	Phosphorylation	SNMQKKQSTLASSNK CHHHHHHHHHHCCCC	33.98	22210691
600	Phosphorylation	NMQKKQSTLASSNKK HHHHHHHHHHCCCCH	24.69	22210691
603	Phosphorylation	KKQSTLASSNKKSKV HHHHHHHCCCCHHHH	37.24	22210691
727	Phosphorylation	QVVMQKVSVCIPTSE HHHEEEEEEEEECHH	20.50	29083192
732	Phosphorylation	KVSVCIPTSEHLSEL EEEEEEECHHHHHHH	27.17	29083192
733	Phosphorylation	VSVCIPTSEHLSELK EEEEEECHHHHHHHH	20.05	29083192
740	Sumoylation	SEHLSELKKEAPAKE HHHHHHHHHHCCCCC	44.51	-
740	Sumoylation	SEHLSELKKEAPAKE HHHHHHHHHHCCCCC	44.51	28112733
794	Phosphorylation	NANSFEGSSTTKSEE CCCCCCCCCCCCCCC	19.81	30576142
795	Phosphorylation	ANSFEGSSTTKSEES CCCCCCCCCCCCCCC	51.45	30576142
796	Phosphorylation	NSFEGSSTTKSEESI CCCCCCCCCCCCCCE	39.68	30576142
799	Phosphorylation	EGSSTTKSEESITVS CCCCCCCCCCCEEEC	44.50	30108239
802	Phosphorylation	STTKSEESITVSDKE CCCCCCCCEEECCCC	21.36	28450419
804	Phosphorylation	TKSEESITVSDKENE CCCCCCEEECCCCCC	24.20	28450419
806	Phosphorylation	SEESITVSDKENETC CCCCEEECCCCCCEE	34.02	26657352
812	Phosphorylation	VSDKENETCLADQET ECCCCCCEEEECCCC	25.13	26657352
826	Phosphorylation	TGSKNIVSCDSNIGA CCCCCEEECCCCCCC	14.38	23403867
829	Phosphorylation	KNIVSCDSNIGADKV CCEEECCCCCCCHHH	34.37	23403867
835	Acetylation	DSNIGADKVEKKKQI CCCCCCHHHHHHHHH	52.32	26051181
856	Phosphorylation	MELKMCQSSENIILS HHHHHHCCCCCEEEC	34.39	27251275
857	Phosphorylation	ELKMCQSSENIILSD HHHHHCCCCCEEECH	14.58	27251275
892	Phosphorylation	RLASDNVSIDQFLRK HHHCCCCCHHHHHHH	27.05	28555341
905	Phosphorylation	RKRHEPESVSSDVSE HHHCCCCCCCCCCCC	37.71	30177828
907	Phosphorylation	RHEPESVSSDVSEQG HCCCCCCCCCCCCCC	30.05	23898821
908	Phosphorylation	HEPESVSSDVSEQGS CCCCCCCCCCCCCCC	39.62	23898821
911	Phosphorylation	ESVSSDVSEQGSIHL CCCCCCCCCCCCEEE	29.23	23898821
915	Phosphorylation	SDVSEQGSIHLEPLT CCCCCCCCEEEEECC	13.41	23898821
922	Phosphorylation	SIHLEPLTPSEVLEY CEEEEECCHHHHHEE	35.17	26074081
924	Phosphorylation	HLEPLTPSEVLEYEA EEEECCHHHHHEEEH	34.79	26074081
929	Phosphorylation	TPSEVLEYEATEILQ CHHHHHEEEHHHHHH	13.50	30177828
951	Phosphorylation	AKTDEVVSDQTDDIP CCCCCCCCCCCCCCC	29.22	28985074
976	Sumoylation	TVDLEDEKERS---- EEECHHHHHCC----	71.41	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of Z280D_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of Z280D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of Z280D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of Z280D_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of Z280D_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530 AND SER-545, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-545, AND MASSSPECTROMETRY.	18220336 [Abstract]