Z280B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: Z280B_HUMAN
• UniProt AC: Q86YH2
• Protein Name: Zinc finger protein 280B
• Gene Name: ZNF280B
• Organism: Homo sapiens (Human).
• Sequence Length: 543
• Subcellular Localization: Nucleus .
• Protein Description: May function as a transcription factor..
• Protein Sequence: MEQSCEEEKEPEPQKNIQETKQVDDEDAELIFVGVEHVNEDAELIFVGVTSNSKPVVSNILNRVTPGSWSRRKKYDHLRKDTARKLQPKSHETVTSEAVTVLPASQLESRSTDSPIIIEPLSKPDYRNSSPQVVPNNSSELPSPLITFTDSLHHPVSTALSVGGINESPRVSKQLSTFEVNSINPKRAKLRDGIIEGNSSASFPSDTFHTMNTQQSTPSNNVHTSLSHVQNGAPFPAAFPKDNIHFKPINTNLDRENELAKTDILSLTSQNKTFDPKKENPIVLLSDFYYGQHKGEGQPEQKTHTTFKCLSCVKVLKNVKFMNHVKHHLEFEKQRNDSWENHTTCQHCHRQFPTPFQLQCHIENVHTAQEPSTVCKICELSFETDQVLLQHMKDHHKPGEMPYVCQVCHYRSSVFADVETHFRTCHENTKNLLCPFCLKIFKTATPYMCHYRGHWGKSAHQCSKCRLQFLTFKEKMEHKTQCHQMFKKPKQLEGLPPETKVTIQVSLEPLQPGSVDVASITVSTSDSEPSLPRSKSKISKKSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQSCEEE -------CCCCCCCC	10.76	19413330
68	Phosphorylation	LNRVTPGSWSRRKKY HHCCCCCCHHHHHHH	24.07	23917254
70	Phosphorylation	RVTPGSWSRRKKYDH CCCCCCHHHHHHHHH	24.73	28112733
105	Phosphorylation	AVTVLPASQLESRST EEEEEEHHHCCCCCC	33.10	17525332
109	Phosphorylation	LPASQLESRSTDSPI EEHHHCCCCCCCCCE	39.87	26074081
111	Phosphorylation	ASQLESRSTDSPIII HHHCCCCCCCCCEEE	45.93	30266825
112	Phosphorylation	SQLESRSTDSPIIIE HHCCCCCCCCCEEEE	39.11	30266825
114	Phosphorylation	LESRSTDSPIIIEPL CCCCCCCCCEEEEEC	20.35	30266825
122	Phosphorylation	PIIIEPLSKPDYRNS CEEEEECCCCCCCCC	53.51	26074081
173	Sumoylation	NESPRVSKQLSTFEV CCCCCHHHCCCCEEC	53.02	28112733
247	Sumoylation	PKDNIHFKPINTNLD CCCCCEECCCCCCCC	30.72	28112733
261	Sumoylation	DRENELAKTDILSLT CCCCHHHHHCHHHHH	60.39	28112733
262	Phosphorylation	RENELAKTDILSLTS CCCHHHHHCHHHHHC	23.75	24719451
266	Phosphorylation	LAKTDILSLTSQNKT HHHHCHHHHHCCCCC	29.90	24719451
268	Phosphorylation	KTDILSLTSQNKTFD HHCHHHHHCCCCCCC	25.53	24719451
451	Phosphorylation	ATPYMCHYRGHWGKS CCCCCCCCCCCCCCC	17.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of Z280B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of Z280B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of Z280B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of Z280B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.
PubMed: 17525332