dbPTM

YTM1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YTM1_SCHPO
UniProt AC	Q9URY0
Protein Name	Ribosome biogenesis protein ytm1 {ECO:0000255\|HAMAP-Rule:MF_03029}
Gene Name	ytm1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	440
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm .
Protein Description	Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome..
Protein Sequence	MDAQSAPSGQVQVRFTTRNEDLAVGDTPIFVPTSLKRYGLSQIVNHLLKTEKPTPFDFLVQGQLLKTTLDEYIVQNGLSTESILDIEYIQSTLPPAYLASFSHDDWISGIQLTSDTILTSSYDGIARVWDKSGEIKFQSTGCGSSLKSASWHIPNQSFLTASLDQKIFHWVIEEPESMLDAEKKSSGILQTLFVGHKDIVERVRSLESSSVFISASADNTVGIWDFERSPETTLESFSSSISKKRRRKNAEFTPQAGARSPLILCEGHTGPVMDIVFSDDPSVAYSVGQDHTIKTWDLITGQNVDSKITKAPLLCVEKLTDLHLVICGSSARHIVVHDPRAGSDKIVSHTLSGHKNLVSGLSASPENPYMFASVSHDNTCRVWDVRATSGSIYTISRAEKTGSQWDKLFAVDWNKSIGIVTGGTDKQLQINQSSSFGKSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
140	Phosphorylation	GEIKFQSTGCGSSLK CCEEEEECCCCCCCC	26.21	28889911
185	Phosphorylation	MLDAEKKSSGILQTL HHCHHHHHCCHHHHH	44.88	25720772
242	Phosphorylation	ESFSSSISKKRRRKN HHHHHHHHHHHHHHC	33.79	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YTM1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YTM1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YTM1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ERB1_SCHPO	SPBC4F6.13c	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YTM1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140 AND SER-242, ANDMASS SPECTROMETRY.	18257517 [Abstract]