YPT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YPT1_SCHPO
• UniProt AC: P11620
• Protein Name: GTP-binding protein ypt1
• Gene Name: ypt1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 203
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasm . Preautophagosomal structure membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Ypt1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins..
• Protein Sequence: MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTFELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDQDSFNNVKQWLQEIDRYAVEGVNRLLVGNKSDMVDKKVVEYSVAKEFADSLNIPFLETSAKDSTNVEQAFLTMSRQIKERMGNNTFASSNAKSSVKVGQGTNVSQSSSNCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	GDSGVGKSCLLLRFA CCCCCCCCEEEEEEC	12.22	25720772
142	Phosphorylation	VAKEFADSLNIPFLE HHHHHHHHCCCCEEC	21.64	25720772
164	Phosphorylation	NVEQAFLTMSRQIKE CHHHHHHHHHHHHHH	13.47	28889911
181	Phosphorylation	GNNTFASSNAKSSVK CCCCCCCCCCCCCEE	37.06	24763107
185	Phosphorylation	FASSNAKSSVKVGQG CCCCCCCCCEEECCC	37.64	25720772
186	Phosphorylation	ASSNAKSSVKVGQGT CCCCCCCCEEECCCC	25.83	25720772
202	Geranylgeranylation	VSQSSSNCC------ CCCCCCCCC------	2.92	1597466
202	Geranylgeranylation	VSQSSSNCC------ CCCCCCCCC------	2.92	1597466
203	Geranylgeranylation	SQSSSNCC------- CCCCCCCC-------	7.96	1597466
203	Geranylgeranylation	SQSSSNCC------- CCCCCCCC-------	7.96	1597466

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YPT1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YPT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YPT1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of YPT1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-164, AND MASSSPECTROMETRY.
PubMed: 18257517

Prenylation

"Post-translational processing of Schizosaccharomyces pombe YPTproteins.";
Newman C.M., Giannakouros T., Hancock J.F., Fawell E.H., Armstrong J.,Magee A.I.;
J. Biol. Chem. 267:11329-11336(1992).
Cited for: ISOPRENYLATION AT CYS-202 AND CYS-203.
PubMed: 1597466