YLAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YLAT1_HUMAN
• UniProt AC: Q9UM01
• Protein Name: Y+L amino acid transporter 1
• Gene Name: SLC7A7
• Organism: Homo sapiens (Human).
• Sequence Length: 511
• Subcellular Localization: Basolateral cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes..
• Protein Sequence: MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVDSTEYEVAS ----CCCCCCEEECC	16.24	23403867
5	Phosphorylation	---MVDSTEYEVASQ ---CCCCCCEEECCC	37.82	26657352
7	Phosphorylation	-MVDSTEYEVASQPE -CCCCCCEEECCCCC	18.78	23403867
11	Phosphorylation	STEYEVASQPEVETS CCCEEECCCCCCCCC	51.98	26657352
17	Phosphorylation	ASQPEVETSPLGDGA CCCCCCCCCCCCCCC	40.60	23403867
18	Phosphorylation	SQPEVETSPLGDGAS CCCCCCCCCCCCCCC	12.48	20639409
25	Phosphorylation	SPLGDGASPGPEQVK CCCCCCCCCCHHHHH	35.60	20639409
325	N-linked_Glycosylation	LSCFGGLNASIVAAS HHHCCCCCHHHHHHH	34.61	UniProtKB CARBOHYD
339	Phosphorylation	SRLFFVGSREGHLPD HHEEEECCCCCCCCC	23.12	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YLAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YLAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YLAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
4F2_HUMAN	SLC3A2	physical	9878049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.