YL066_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YL066_YEAST
• UniProt AC: Q99208
• Protein Name: Y' element ATP-dependent helicase YLL066C
• Gene Name: YLL066C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1374
• Protein Description: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance..
• Protein Sequence: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRRYGYNLAPHMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYNKNGSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSNTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFGLCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWVDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
322	Ubiquitination	NAEDVVAGEAASSDH CHHHHHHHHHCCCCH	17.29	17644757
326	Phosphorylation	VVAGEAASSDHDQKI HHHHHHCCCCHHHHH	43.26	22369663
327	Phosphorylation	VAGEAASSDHDQKIS HHHHHCCCCHHHHHH	33.95	22369663
334	Phosphorylation	SDHDQKISRVTRKRP CCHHHHHHHHHCCCC	27.95	21082442
357	Ubiquitination	ILVAGQKLFGSSFEF EEEECHHHHCCCCCC	4.52	17644757
414	Ubiquitination	SKGDVKYVSFLFVPY CCCCCCEEEEEEHHH	2.43	17644757
416	Ubiquitination	GDVKYVSFLFVPYTV CCCCEEEEEEHHHHH	4.35	17644757
426	Ubiquitination	VPYTVLLANCMIRLG HHHHHHHHHHHHHHC	11.74	17644757
429	Ubiquitination	TVLLANCMIRLGRCG HHHHHHHHHHHCCCC	1.68	17644757
430	Ubiquitination	VLLANCMIRLGRCGC HHHHHHHHHHCCCCC	3.42	17644757
440	Ubiquitination	GRCGCLNVAPVRNFI CCCCCCCCHHHHHHH	4.03	17644757
590	Ubiquitination	KEKSEVPLGHVHKIW HHCCCCCCCHHHHHH	10.02	17644757
591	Ubiquitination	EKSEVPLGHVHKIWK HCCCCCCCHHHHHHH	18.07	17644757
725	Phosphorylation	YLLSRKNSWAARNRK EEEECCCCHHHHCCC	22.56	27214570
808	Phosphorylation	LPSSFQESNSSDRCR CCCCCCCCCCCHHHH	31.09	28889911
810	Phosphorylation	SSFQESNSSDRCRKY CCCCCCCCCHHHHHH	42.78	28889911
811	Phosphorylation	SFQESNSSDRCRKYC CCCCCCCCHHHHHHC	33.07	28889911
836	Ubiquitination	HGSANASTNATTNSS CCCCCCCCCCCCCCC	26.85	17644757
846	Ubiquitination	TTNSSTNATTTASTN CCCCCCCCEEECCCE	13.35	17644757
849	Ubiquitination	SSTNATTTASTNVRT CCCCCEEECCCEEEC	17.79	17644757
851	Phosphorylation	TNATTTASTNVRTSA CCCEEECCCEEECCE	20.58	28889911
856	Phosphorylation	TASTNVRTSATTTAS ECCCEEECCEEEEEE	20.59	27017623
861	Phosphorylation	VRTSATTTASINVRT EECCEEEEEEEEEEC	17.66	27017623
878	Phosphorylation	TTTESTNSSTNATTT EEECCCCCCCCCEEE	38.33	29688323
879	Phosphorylation	TTESTNSSTNATTTA EECCCCCCCCCEEEE	27.96	29688323
880	Phosphorylation	TESTNSSTNATTTAS ECCCCCCCCCEEEEE	28.79	29688323
883	Phosphorylation	TNSSTNATTTASTNV CCCCCCCEEEEECCE	27.09	29688323
884	Phosphorylation	NSSTNATTTASTNVR CCCCCCEEEEECCEE	20.25	29688323
885	Phosphorylation	SSTNATTTASTNVRT CCCCCEEEEECCEEC	17.79	29688323
887	Phosphorylation	TNATTTASTNVRTSA CCCEEEEECCEECCE	20.58	28889911
888	Phosphorylation	NATTTASTNVRTSAT CCEEEEECCEECCEE	34.96	29688323
892	Phosphorylation	TASTNVRTSATTTAS EEECCEECCEEEEEE	20.59	27017623
897	Phosphorylation	VRTSATTTASINVRT EECCEEEEEEEEEEE	17.66	27017623
960	Ubiquitination	NATTTASTNSSTNAT CCEEEEECCCCCCCC	36.33	17644757
967	Phosphorylation	TNSSTNATTTESTNA CCCCCCCCCCCCCCC	36.00	27017623
969	Phosphorylation	SSTNATTTESTNASA CCCCCCCCCCCCCHH	24.47	27017623
972	Phosphorylation	NATTTESTNASAKED CCCCCCCCCCHHHHH	28.68	27017623
994	Ubiquitination	EDNRFHPVTDINKES CCCCCCCCCCCCHHH	5.88	23749301
1007	Phosphorylation	ESYKRKGSQMVLLER HHHHCCCCEEEEEEH	20.38	25752575
1077	Ubiquitination	KMFGLCVCWAGQKVS HHHCEEEECCCCCCC	1.69	24961812
1233	Phosphorylation	GVFQRLRSMTSAGLQ CHHHHHHHCCCCCCC	30.88	27017623
1244	Phosphorylation	AGLQGPQYVKLQFSR CCCCCCCEEEEEECH	11.59	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YL066_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YL066_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YL066_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of YL066_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.