dbPTM

YI13_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YI13_SCHPO
UniProt AC	Q9P7B4
Protein Name	NADP-dependent 3-hydroxy acid dehydrogenase {ECO:0000250\|UniProtKB:Q05016}
Gene Name	SPAC521.03
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	259
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate..
Protein Sequence	MSRLDGKTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLDVSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMTRAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRIRIMEVDPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDIAEVILFALTRRENVVIADTLVFPSHQGGANHVYRKQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	TILITGASSGIGKST EEEEEECCCCCCCCC	30.37	25720772
21	Phosphorylation	ASSGIGKSTAFEIAK CCCCCCCCCHHHHHH	21.54	25720772
42	Phosphorylation	ILAARRFSTVEEIAK HHHCCCCCCHHHHHH	29.72	28889911
43	Phosphorylation	LAARRFSTVEEIAKE HHCCCCCCHHHHHHH	29.26	28889911
71	Phosphorylation	LDVSDLKSIPGVIES CCHHHHHCCCCHHHH	41.11	25720772
134	Phosphorylation	AVLPIFYSKNKGDIL HHHHHHCCCCCCCEE	21.00	25720772
145	Phosphorylation	GDILNVGSIAGRESY CCEEEECCCCCCCCC	12.65	25720772
163	Phosphorylation	SVYCSTKSALAQFTS EEEECHHHHHHHHHH	28.71	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YI13_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YI13_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YI13_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of YI13_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YI13_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-43, AND MASSSPECTROMETRY.	18257517 [Abstract]