YF21B_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YF21B_YEAST
• UniProt AC: P0CX63
• Protein Name: Transposon Ty2-F Gag-Pol polyprotein
• Gene Name: TY2B-F
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1770
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity).; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity).; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)..
• Protein Sequence: MESQQLHQNPHSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKSQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSINPLQLDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTVESDTTSPRHSSTFTARNQNRPGSTNEMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAVCDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTHKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNKEKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESQQLHQNP -----CCCCCCCCCC	34.78	24961812
12	Phosphorylation	QLHQNPHSLHGSAYA CCCCCCCCCCCCEEE	24.26	24961812
16	Phosphorylation	NPHSLHGSAYASVTS CCCCCCCCEEEEEEC	13.83	24961812
18	Phosphorylation	HSLHGSAYASVTSKE CCCCCCEEEEEECCC	10.91	24961812
20	Phosphorylation	LHGSAYASVTSKEVP CCCCEEEEEECCCCC	17.16	24961812
22	Phosphorylation	GSAYASVTSKEVPSN CCEEEEEECCCCCCC	31.42	24961812
23	Phosphorylation	SAYASVTSKEVPSNQ CEEEEEECCCCCCCC	25.35	24961812
28	Phosphorylation	VTSKEVPSNQDPLAV EECCCCCCCCCCCCE	52.91	22369663
36	Phosphorylation	NQDPLAVSASNLPEF CCCCCCEECCCCCCC	22.00	22369663
38	Phosphorylation	DPLAVSASNLPEFDR CCCCEECCCCCCCCC	31.24	22369663
47	Phosphorylation	LPEFDRDSTKVNSQQ CCCCCCCCCCCCCCC	30.90	22369663
48	Phosphorylation	PEFDRDSTKVNSQQE CCCCCCCCCCCCCCC	43.21	22369663
52	Phosphorylation	RDSTKVNSQQETTPG CCCCCCCCCCCCCCC	35.91	28889911
57	Phosphorylation	VNSQQETTPGTSAVP CCCCCCCCCCCCCCC	20.97	18407956
71	Phosphorylation	PENHHHVSPQPASVP CCCCCCCCCCCCCCC	17.29	18407956
85	Phosphorylation	PPPQNGQYQQHGMMT CCCCCCCCCCCCCCC	16.13	27738172
92	Phosphorylation	YQQHGMMTPNKAMAS CCCCCCCCCCHHHHC	18.15	18407956
115	Phosphorylation	SMMTCSHYQTSPAYY CCCCCCCCCCCCCCC	9.37	18407956
117	Phosphorylation	MTCSHYQTSPAYYQP CCCCCCCCCCCCCCC	29.52	18407956
118	Phosphorylation	TCSHYQTSPAYYQPD CCCCCCCCCCCCCCC	7.63	18407956
140	Phosphorylation	YIPPLSTSSPDPIDS CCCCCCCCCCCCCCC	36.18	28889911
141	Phosphorylation	IPPLSTSSPDPIDSQ CCCCCCCCCCCCCCC	33.15	28889911
152	Phosphorylation	IDSQNQHSEVPQAET CCCCCCCCCCCHHHH	30.44	28889911
355	Phosphorylation	IMNLNKPSQYKQHSE CCCCCCHHHCCCCCC	47.99	21551504
367	Phosphorylation	HSEYKNVSRTSPNTT CCCCCCCCCCCCCCC	38.95	22369663
369	Phosphorylation	EYKNVSRTSPNTTNT CCCCCCCCCCCCCCC	40.82	22369663
370	Phosphorylation	YKNVSRTSPNTTNTK CCCCCCCCCCCCCCC	18.29	22369663
373	Phosphorylation	VSRTSPNTTNTKVTT CCCCCCCCCCCCEEE	25.47	22369663
374	Phosphorylation	SRTSPNTTNTKVTTR CCCCCCCCCCCEEEC	47.75	22369663
376	Phosphorylation	TSPNTTNTKVTTRNY CCCCCCCCCEEECCC	25.46	22369663
379	Phosphorylation	NTTNTKVTTRNYHRT CCCCCCEEECCCCCC	22.92	27017623
380	Phosphorylation	TTNTKVTTRNYHRTN CCCCCEEECCCCCCC	21.65	17287358
383	Phosphorylation	TKVTTRNYHRTNSSK CCEEECCCCCCCCCC	6.87	27017623
388	Phosphorylation	RNYHRTNSSKPRAAK CCCCCCCCCCCCHHH	38.84	17287358
406	Phosphorylation	IATSSKFSRVNNDHI HHCCCCCCCCCCCCC	38.77	19823750
416	Phosphorylation	NNDHINESTVSSQYL CCCCCCCCHHCCCCC	29.62	22369663
417	Phosphorylation	NDHINESTVSSQYLS CCCCCCCHHCCCCCC	20.44	22369663
419	Phosphorylation	HINESTVSSQYLSDD CCCCCHHCCCCCCCC	16.29	22369663
420	Phosphorylation	INESTVSSQYLSDDN CCCCHHCCCCCCCCC	20.64	22369663
422	Phosphorylation	ESTVSSQYLSDDNEL CCHHCCCCCCCCCCC	15.32	22369663
424	Phosphorylation	TVSSQYLSDDNELSL HHCCCCCCCCCCCCH	37.67	22369663
430	Phosphorylation	LSDDNELSLGQQQKE CCCCCCCCHHHCHHH	25.03	22369663
446	Phosphorylation	KPTHTIDSNDELPDH CCCCCCCCCCCCCCE	42.18	19779198
570	Phosphorylation	SKKYLIPSHISKLTI ECCCCCCHHHHHCEE	26.85	28889911
621	Phosphorylation	AVTYLKESDIEWSNA CEEEEEHHHCCCCCC	42.15	21440633
773	Phosphorylation	VAERLNRTLLNDCRT HHHHHHHHHHHHHHH	34.23	19779198
785	Phosphorylation	CRTLLHCSGLPNHLW HHHHHHCCCCCCCEE	32.39	19779198
800	Phosphorylation	FSAVEFSTIIRNSLV EEEHHHHHHHHHCCC	26.24	19779198
991	Phosphorylation	ILPSTIRSRTPHIIN CCCHHHHCCCCCEEC	36.33	30377154
993	Phosphorylation	PSTIRSRTPHIINKE CHHHHCCCCCEECCC	22.06	21440633
1010	Phosphorylation	EMGGTVESDTTSPRH CCCCEEECCCCCCCC	35.60	28889911
1012	Phosphorylation	GGTVESDTTSPRHSS CCEEECCCCCCCCCC	38.15	23749301
1013	Phosphorylation	GTVESDTTSPRHSST CEEECCCCCCCCCCC	41.55	19779198
1014	Phosphorylation	TVESDTTSPRHSSTF EEECCCCCCCCCCCE	23.25	17330950
1019	Phosphorylation	TTSPRHSSTFTARNQ CCCCCCCCCEEECCC	22.78	27017623
1020	Phosphorylation	TSPRHSSTFTARNQN CCCCCCCCEEECCCC	28.20	25752575
1032	Phosphorylation	NQNRPGSTNEMIDLT CCCCCCCCCCCEECC	40.90	27017623
1053	Phosphorylation	YGLENIKTTRLGGTE HCCCCCEEEECCCCC	17.22	24961812
1054	Phosphorylation	GLENIKTTRLGGTEE CCCCCEEEECCCCCC	20.92	24961812
1059	Phosphorylation	KTTRLGGTEEPYIQR EEEECCCCCCCCCCC	35.06	24961812
1063	Phosphorylation	LGGTEEPYIQRNSDT CCCCCCCCCCCCCCC	16.99	21440633
1068	Phosphorylation	EPYIQRNSDTNIKYR CCCCCCCCCCCCEEE	48.26	25752575
1070	Phosphorylation	YIQRNSDTNIKYRTT CCCCCCCCCCEEECC	38.37	27017623
1076	Phosphorylation	DTNIKYRTTNSTPSI CCCCEEECCCCCCCC	27.52	24961812
1077	Phosphorylation	TNIKYRTTNSTPSID CCCEEECCCCCCCCC	20.41	24961812
1079	Phosphorylation	IKYRTTNSTPSIDDR CEEECCCCCCCCCCC	39.33	24961812
1080	Phosphorylation	KYRTTNSTPSIDDRS EEECCCCCCCCCCCC	24.11	24961812
1082	Phosphorylation	RTTNSTPSIDDRSSN ECCCCCCCCCCCCCC	38.44	25704821
1087	Phosphorylation	TPSIDDRSSNSESTT CCCCCCCCCCCCCCC	40.65	17330950
1088	Phosphorylation	PSIDDRSSNSESTTP CCCCCCCCCCCCCCC	45.31	21440633
1090	Phosphorylation	IDDRSSNSESTTPII CCCCCCCCCCCCCEE	34.57	17330950
1092	Phosphorylation	DRSSNSESTTPIISI CCCCCCCCCCCEEEE	37.08	21440633
1093	Phosphorylation	RSSNSESTTPIISIE CCCCCCCCCCEEEEE	32.32	17330950
1094	Phosphorylation	SSNSESTTPIISIET CCCCCCCCCEEEEEE	23.05	17330950
1098	Phosphorylation	ESTTPIISIETKAVC CCCCCEEEEEEEEEC	18.32	24961812
1101	Phosphorylation	TPIISIETKAVCDNT CCEEEEEEEEECCCC	23.72	24961812
1108	Phosphorylation	TKAVCDNTPSIDTDP EEEECCCCCCCCCCC	12.74	21551504
1110	Phosphorylation	AVCDNTPSIDTDPPE EECCCCCCCCCCCCC	30.93	28889911
1113	Phosphorylation	DNTPSIDTDPPEYRS CCCCCCCCCCCCCCC	49.05	27017623
1125	Phosphorylation	YRSSDHATPNIMPDK CCCCCCCCCCCCCCC	17.28	17330950
1141	Phosphorylation	SKNVTADSILDDLPL CCCCCCCHHHCCCCC	23.68	21440633
1155	Phosphorylation	LPDLTHKSPTDTSDV CCCCCCCCCCCCCCC	25.98	25315811
1157	Phosphorylation	DLTHKSPTDTSDVSK CCCCCCCCCCCCCCC	60.03	27717283
1159	Phosphorylation	THKSPTDTSDVSKDI CCCCCCCCCCCCCCC	29.33	27717283
1160	Phosphorylation	HKSPTDTSDVSKDIP CCCCCCCCCCCCCCC	38.53	27717283
1174	Phosphorylation	PHIHSRQTNSSLGGM CCCCCCCCCCCCCCC	35.64	27017623
1176	Phosphorylation	IHSRQTNSSLGGMDD CCCCCCCCCCCCCCC	30.26	27017623
1177	Phosphorylation	HSRQTNSSLGGMDDS CCCCCCCCCCCCCCC	32.86	19779198
1184	Phosphorylation	SLGGMDDSNVLTTTK CCCCCCCCCCEECCC	25.27	27017623
1188	Phosphorylation	MDDSNVLTTTKSKKR CCCCCCEECCCCCCC	28.30	27017623
1189	Phosphorylation	DDSNVLTTTKSKKRS CCCCCEECCCCCCCC	28.24	27017623
1190	Phosphorylation	DSNVLTTTKSKKRSL CCCCEECCCCCCCCC	28.25	27017623
1192	Phosphorylation	NVLTTTKSKKRSLED CCEECCCCCCCCCCC	41.12	19779198
1301	Phosphorylation	DPKKVINSMFIFNKK CHHHHHCEEEEEECC	12.16	24909858
1402	Phosphorylation	SLYGLKQSGANWYET HHHCCHHCCCCHHHH	37.98	19779198
1407	Phosphorylation	KQSGANWYETIKSYL HHCCCCHHHHHHHHH	11.73	19779198
1704	Phosphorylation	LLTDSRSTISIIKST HHCCCCHHHEEEECC	20.03	21440633
1711	Phosphorylation	TISIIKSTNEEKFRN HHEEEECCCHHHHHH	41.46	27017623
1753	Phosphorylation	KNIADVMTKPLPIKT CCHHHHHCCCCCCCC	29.38	20377248

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YF21B_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YF21B_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YF21B_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of YF21B_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.