Y5521_DROME - dbPTM
Y5521_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID Y5521_DROME
UniProt AC Q9VB98
Protein Name Probable Rho GTPase-activating protein CG5521
Gene Name CG5521
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1958
Subcellular Localization
Protein Description
Protein Sequence MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQAEANLKQKVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKLRREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGMASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKDHRAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMRSINKKEEVMASCVVVLINWVSRFTHERLLSHRLDCTLHIEDVDQVRLHGYQQGLIVRDVLYVNRENINFVHEVYRQAFLLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPNDDPPPPSNAGGTPRSQRLRTPSYVGAIAGSKDQLVVRAGRQNVLQVFVTNAANVFLVNTANLNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSGTNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIGSVWQGSGSNSAANGGSAASAAISQNRQRESLAESSSSRSEETSSQVPLPNHPRPHHQHTQSQGGTGHGTRPIPLTPMLSRSYSEGSLASAARSSRIRRRRAATPKPKALQPSQLAENRINPQDLRRAMSLDSLARKGDAEETDSYQEGDNESGAGSRSPSPTASSGIEGGSIKDAQLQIDASLDDANSGSYGSGSNSGSISGRRCIILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQGAVNMQQLPLFYHALHQLLTGEDRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYPSSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERGRQLAAIERVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPFNEQGDTLVLQVLRVLLQVASGAPRHERVKLTADDDFDMHIAHDDLQGDGRLPEATYQTSETIQKCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVELPSVVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQGCGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAGSTAAMEAATGMSSASPRGPRKLGAPFKSVTKKHSLQHIAVGGGAGAGGDTPPESPTLPQRRFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
429PhosphorylationSQRLRTPSYVGAIAG
HHHCCCCCCCHHHCC		31.6622817900
430PhosphorylationQRLRTPSYVGAIAGS
HHCCCCCCCHHHCCC		12.2421082442
665PhosphorylationSQNRQRESLAESSSS
HHHHHHHHHHHCCCC		34.7622817900
716PhosphorylationLTPMLSRSYSEGSLA
CCCCCCCCCCCCCHH		29.6327626673
718PhosphorylationPMLSRSYSEGSLASA
CCCCCCCCCCCHHHH		36.4121082442
721PhosphorylationSRSYSEGSLASAARS
CCCCCCCCHHHHHHH		19.4021082442
738PhosphorylationIRRRRAATPKPKALQ
HHHHHCCCCCCCCCC		30.7521082442
764PhosphorylationQDLRRAMSLDSLARK
HHHHHHHCHHHHHHC		28.2119429919
767PhosphorylationRRAMSLDSLARKGDA
HHHHCHHHHHHCCCH		29.2619429919
787PhosphorylationYQEGDNESGAGSRSP
CCCCCCCCCCCCCCC		39.9522817900
791PhosphorylationDNESGAGSRSPSPTA
CCCCCCCCCCCCCCC		29.1122817900
793PhosphorylationESGAGSRSPSPTASS
CCCCCCCCCCCCCCC		31.2822817900
795PhosphorylationGAGSRSPSPTASSGI
CCCCCCCCCCCCCCC		35.8122817900
980PhosphorylationGEDRDLIYAILKHLE
CCCHHHHHHHHHHCC		8.5522817900
1132PhosphorylationHPKASSVYNPRIKEV
CCCCCCCCCHHHHHH		22.7722817900
1540PhosphorylationTHSTQAPSPALRHAS
CCCCCCCCHHHHCCC		26.3122817900
1547PhosphorylationSPALRHASSNSSLQQ
CHHHHCCCCCCCCCC		24.7519429919
1548PhosphorylationPALRHASSNSSLQQP
HHHHCCCCCCCCCCC		41.3319429919
1550PhosphorylationLRHASSNSSLQQPDQ
HHCCCCCCCCCCCCC		34.0819429919
1551PhosphorylationRHASSNSSLQQPDQR
HCCCCCCCCCCCCCC		34.1519429919
1862PhosphorylationSSAAPLASALLDHNR
CCHHHHHHHHHHCCC		27.4221082442
1871PhosphorylationLLDHNRASVKGWVQA
HHHCCCHHHCCEEEE		22.5622817900
1945PhosphorylationGAGAGGDTPPESPTL
CCCCCCCCCCCCCCC		43.9819429919
1949PhosphorylationGGDTPPESPTLPQRR
CCCCCCCCCCCCCCC		29.0319429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of Y5521_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of Y5521_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of Y5521_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of Y5521_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of Y5521_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-718; SER-764; SER-767;SER-787; SER-791; SER-793; SER-795; SER-1551; THR-1945 AND SER-1949,AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-980, AND MASSSPECTROMETRY.

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