dbPTM

Y4230_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	Y4230_DROME
UniProt AC	Q9VWD4
Protein Name	Probable RNA-binding protein CG14230
Gene Name	CG14230
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	580
Subcellular Localization
Protein Description
Protein Sequence	MGSTRFFLADLPTRTSESDLQILFQDYGHVEHVDLKRKEQDGATKVIAFVTVQTDDAQYCVNELKWQKLHGEKLRVSLAKESFLDRLKREREENQRREQGEPDESEVRAPSSQLLVQSGQNKRRVFGEDEEIGDDEVAPELLITKKRAANSMHNGRIVIQQEHDVKPLHVIEQHRKAAKQKPDANVSQAEQKRKESLNKMRQGHQQKKSAIQQALSVISVEGSQAKRIKFSDAEEEEASKPVQKAKIQKRDLFENDDDEEEEQIVLPQHKGKKGERLVEMQSKQSIDPRFRITSNFVNEEEEAELEDQPEPEESERKWHMNILEQVVGHAITSANDKDGKSPKNKKMLRFDPAKEGHQKLMRQKQPKEEEEKKEETSSTKAKTADAGNSQASAVSKTAFYIVTDTLRDSLNTRGEGFSLLDMFGSAPEKEVAKRQDQLEKLGHEKILVGKTSANKLGLATLNPFSYDSSDSEDETEVKPKQEQEQEQELEVSKENKAQPAKKSGQKRNKNKLESFFIPRNDPRLKEGAKFFKSTKAVVDHAEYDQVKNRLKLLITKKIAKAKKSLPSKDIKLQRNKKGKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	Phosphorylation	SAIQQALSVISVEGS HHHHHHHHHHCCCCC	22.03	21082442
219	Phosphorylation	QQALSVISVEGSQAK HHHHHHHCCCCCCCE	16.38	22817900
231	Phosphorylation	QAKRIKFSDAEEEEA CCEECCCCCHHHHHH	30.80	21082442
341	Phosphorylation	ANDKDGKSPKNKKML CCCCCCCCCCCCCCC	46.78	22817900
460	Phosphorylation	ANKLGLATLNPFSYD CCCCCCEECCCCCCC	31.91	19429919
465	Phosphorylation	LATLNPFSYDSSDSE CEECCCCCCCCCCCC	29.32	19429919
466	Phosphorylation	ATLNPFSYDSSDSED EECCCCCCCCCCCCC	21.89	19429919
468	Phosphorylation	LNPFSYDSSDSEDET CCCCCCCCCCCCCCC	28.01	19429919
469	Phosphorylation	NPFSYDSSDSEDETE CCCCCCCCCCCCCCC	42.11	19429919
471	Phosphorylation	FSYDSSDSEDETEVK CCCCCCCCCCCCCCC	49.23	19429919
475	Phosphorylation	SSDSEDETEVKPKQE CCCCCCCCCCCCHHH	59.40	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of Y4230_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of Y4230_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of Y4230_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of Y4230_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of Y4230_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468 AND THR-475, ANDMASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	17372656 [Abstract]